Endometrial hyperplasia classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]

Overview

Endometrial hyperplasia may be broadly classified based on histology into simple and complex types. Endometrial hyperplasia may also be classified based on the presence or absence of cellular atypia (hyperplasia with cellular atypia and hyperplasia without cellular atypia).[1][2][3]

Classification

The World Health Organization (WHO) Classification System

The WHO Classification (1994)

  • Endometrial hyperplasia may be classified based on glandular complexity and nuclear atypicality into the following types:[1][2][3]
 
 
 
 
 
 
 
 
 
Endometrial hyperplasia
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Simple
 
 
 
 
 
Complex
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Simple hyperplasia with cellular atypia
 
Simple hyperplasia without cellular atypia
 
Complex hyperplasia with cellular atypia
 
Complex hyperplasia without cellular atypia

The New WHO Classification (2014)

  • The new WHO classification has been proposed to simplify clinical decision making, particularly when making treatment choices.[4]
  • Endometrial hyperplasia may be classified according to new WHO classification (1994) into:
    • Hyperplasia without atypia
    • Atypical hyperplasia/endometrioid intraepithelial neoplasia

The Endometrial Intraepithelial Neoplasia (EIN) Classification

References

  1. 1.0 1.1 Scully RE. Histological typing of female genital tract tumours. Springer; 1994.
  2. 2.0 2.1 Endometrial hyperplasia. Radiopedia. http://radiopaedia.org/articles/endometrial-hyperplasia-1 Accessed on March 3, 2016.
  3. 3.0 3.1 Jorizzo JR, Chen MY, Martin D, Dyer RB, Weber TM (2002). "Spectrum of endometrial hyperplasia and its mimics on saline hysterosonography". AJR Am J Roentgenol. 179 (2): 385–9. doi:10.2214/ajr.179.2.1790385. PMID 12130438.
  4. Emons G, Beckmann MW, Schmidt D, Mallmann P, Uterus commission of the Gynecological Oncology Working Group (AGO) (2015). "New WHO Classification of Endometrial Hyperplasias". Geburtshilfe Frauenheilkd. 75 (2): 135–136. doi:10.1055/s-0034-1396256. PMC 4361167. PMID 25797956.

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