Multiple endocrine neoplasia type 1 natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Natural History
The symptoms of multiple endocrine neoplasia type 1 usually develop in the first/ second/ third decade of life, and start with symptoms such as ___. The symptoms of multiple endocrine neoplasia type 1 typically develop ___ years after exposure to ___. Without treatment, the patient will develop symptoms of ___, which will/ may eventually lead to ___.
Complications
- Complications that can develop as a result of multiple endocrine neoplasia type 1 are as belows.
- Hypoglycemia
- Diabetes
- Watery diarrhea
- Cushing's syndrome
- Infertility
- Impotency
Prognosis
- The prognosis of multiple endocrine neoplasia type 1 is good with treatment.
- Most people with MEN1 have a long and productive life.
- Although many tumors associated with MEN1 are benign, about half of people with MEN1 will eventually develop a cancerous tumor.
- The presence of pancreatic tumors is associated with a particularly poor prognosis among patients with multiple endocrine neoplasia type 1.