Heartburn causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Divya Yadav MD [2] Luke Rusowicz-Orazem, B.S.

Overview

Heartburn is commonly caused by sources of acid reflux, including adverse reactions with various food and drugs. Other causes are far less common, but are potentially life-threatening.

Causes

Heartburn is commonly caused by sources of acid reflux, including adverse reactions with various food and drugs.
Esophageal and gastrointestinal cancer are potentially life threatening causes of heartburn and require prompt diagnosis and management.

Life Threatening Causes

Common Causes

Causes by Organ System

Cardiovascular	Celiac artery stenosis , Diffuse systemic sclerosi , Nocturnal heartburn , Pylephlebitis
Chemical/Poisoning	1,2-dibromo-3-chloropropane , Acid regurgitation, Alcohol, Aromatic amino acid decarboxylase deficiency , Callistin shellfish poisoning , Citrus fruit, Copper toxicity , Niacin toxicity , Nickel carbonyl , Pollen food allergy syndrome , Pyresmethrin , Silafluofen , Smoking, Sodas , Sulfite , Tobacco products , Tomatoes , Vinyl choride
Dental	No underlying causes
Dermatologic	Scleroderma
Drug Side Effect	Acrinathrin , Alpha-cypermethrin , Amines , Barthrin , Beta-cyfluthrin , Beta-cypermethrin , Bifenthrin , Bioallethrin , Bioehtanomethrin , Biopermethrin , Bioresmethrin, Caffeine , Cismethrin , Cyclethrin , Cyfluthrin , Cyhalothrin , Cyllprothrin , Cyphenothrin , Deltamethrin , Dimefluthrin, Dimethrin , Empenthrin , Esfenvalerate , Fenfluthrin, Fenpirithrin , Fenpropathrin , Fenvalerate , Flucythrinate , Flufenprox , Flurbiprofen, Fluvalinate , Furethrin , Gamma-cyhalothrin , Glucosamine , Halfenprox , Ibuprofen, Imiprothrin , Indinavir, Ketorolac tromethamine, Lambda-cyhalothrin , Methamphetamine , Methylene dianiline , Metofluthrin , Oxaprozin, Piroxicam, Prallethrin , Profluthrin , Protrifenbute , Pyrethroid , Salicylate , Tau-fluvalinate , Tefluthrin , Theta-cypermethrin , Tolbutamide, Tralomethrin , Transfluthrin , Transpermethrin, Zeta-cypermethrin
Ear Nose Throat	Achalasia cardia, Sjogren's syndrome
Endocrine	Carnitine-acylcarnitine translocase deficiency , Secondary hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	Achalasia cardia, Acute gastritis, Acute oesophagitis, Barrett esophagus , Celiac artery stenosis , Crohn's disease of the esophagus , Decreased gastrointestinal motility , Esophageal carcinoma , Esophageal ulcer , Esophagus cancer , Gastric lymphoma , Gastroesophageal reflux disease , Gastrointestinal motility disorders, Indigestion , Janbon syndrome , Microgastria short stature diabetes , Mitochondrial neurogastrointestinal encephalopathy syndrome, Peptic ulcer, Reflux , Sandifer syndrome , Schatzki ring , Short bowel syndrome , Stomach cancer , Stomach emptying disorders, Weak esophageal muscles, Zieve syndrome , Zollinger-ellison syndrome
Genetic	Bbb syndrome, Brachmann-de lange syndrome , Chromosome 12p tetrasomy syndrome , Chromosome 1p deletion syndrome , Chromosome 22q deletion syndrome , Chromosome 9q deletion syndrome , Congenital microgastria limb reduction defect , Cornelia de lange syndrome 1 , Deletion of the short arm of chromosome 1 , Emanuel syndrome, Hypertelorism, Nyssen-van bogaert syndrome , Opitz syndrome , Pallister-killian syndrome, Smith-lemli-opitz syndrome , Wagr syndrome , Worster drought syndrome , X-linked alpha thalassemia mental retardation syndrome
Hematologic	Carnitine-acylcarnitine translocase deficiency , Familial infantile metachromatic leukodystrophy , Microgastria short stature diabetes , Velocardiofacial syndrome , Wilms tumor
Iatrogenic	No underlying causes
Infectious Disease	Ankylostomiasis , Fascioliasis , Helicobacter pylori bacteria, Pylephlebitis , Strongyloidiasis
Musculoskeletal/Orthopedic	Congenital microgastria limb reduction defect , Rest syndrome, Spastic paraplegia 9
Neurologic	Mental retardation, Mitochondrial neurogastrointestinal encephalopathy syndrome, Polyneuropathy , Rest syndrome, Sleep apnea syndromes , Spastic paraplegia 9, X-linked alpha thalassemia mental retardation syndrome
Nutritional/Metabolic	Chocolate, Citrus fruit, Fatty foods , Food additives , Garlic, Msg , Naproxen sodium, Peanuts, Peppermint , Red pepper , Sodas , Spicy foods, Tomatoes , Wine
Obstetric/Gynecologic	Pregnancy
Oncologic	Esophagus cancer , Gastric lymphoma , Lymphoma, Stomach cancer , Wilms tumor , Zollinger-ellison syndrome
Ophthalmologic	No underlying causes
Overdose/Toxicity	Alcohol, Caffeine , Peanuts, Peppermint , Pollen food allergy syndrome
Psychiatric	Stress
Pulmonary	Mediastinitis , Sleep apnea syndromes
Renal/Electrolyte	No underlying causes
Rheumatology/Immunology/Allergy	Allergenic cross-reactivity , Gluten allergy , Grain-based foods, Scleroderma
Sexual	No underlying causes
Trauma	Hiatus hernia
Urologic	Hypospadias
Miscellaneous	No underlying causes

Causes in Alphabetical Order

References