Sandbox:Asra

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Asra Firdous,M.B.B.S.[1]


Ewing's sarcoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [3];Assistant Editor(s)-In-Chief: Michael Maddaleni, B.S., Asra Firdous, M.B.B.S.

Overview

Ewing's sarcoma is the second most common malignant bone neoplasm commonly affecting children and adolescents. It usually affects patients in the second decade of life with a peak incidence around 15 years of age. It comprises 3% of all malignancies in pediatric patients and about 10-15% of childhood bone cancers. The overall incidence of Ewing's sarcoma is approximately estimated at 2.9 cases per million population in the U.S. Ewing's sarcoma is more common in males than females. It is more prevalent in whites than Africans.

Epidemiology and Demographics

Incidence

Mortality/Morbidity

The overall 5-year survival rate for patients with Ewing's Sarcoma is approximately 70% in primary lesions and 30% in metastatic disease.

Race

  • Ewing's Sarcoma is more prevalent in Caucasians than Asians or Hispanics.
  • African Americans and Africans are less likely to develop Ewing's Sarcoma.
  • The incidence in the Caucasians is 1.5 cases per million population.
  • The incidence in the Asians is 0.8 cases per million population.
  • The incidence in Africans is 0.2 cases per million population.

Age

  • Ewing's Sarcoma commonly affects children and adolescents between 10 and 20 years of age.
  • The median age at diagnosis is 15 years
  • In patients younger than 5 years, diagnosed in about 0.6 cases per million population.
  • In patients aged 10-14 years, diagnosed in about more than 5 cases per million population.

Gender

  • Males are more commonly affected than females. The male to female ratio is around 3:2.

Reference

  1. Ewing's sarcoma. National cancer institute.http://www.cancer.gov/types/bone/hp/ewing-treatment-pdq#section/_1