Sandbox:Hannan
Myeloproliferative neoplasms (MPN) | Clinical manifestations | Diagnosis | Other features | |||||||||||||
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Symptoms | Physical examination | Lab findings | Bone marrow biopsy | Gold standard | Other investigations | |||||||||||
WBCs | RBCs | Platelets | ||||||||||||||
Leukocytosis | Blasts | Left shift | Basophilia | Eosinophilia | Monocytosis | Others | ||||||||||
Chronic myeloid leukemia
(CML), BCR-ABL1+ |
Asymptomatic
Non-specific Hyperviscosity related Anemia related Bleeding Infection |
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absolute leukocytosis (median of 100,000/µL) | blasts usually <2% |
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absolute basophilia is almost always present | absolute eosinophilia in 90% of patients | often present | Anemia |
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Bone marrow aspirate and unilateral biopsy with conventional cytogenetics and flow cytometry | |||||
Chronic neutrophilic leukemia (CNL) | ||||||||||||||||
Polycythemia vera (PV) | ||||||||||||||||
Primary myelofibrosis (PMF)
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Essential thrombocythemia (ET) | ||||||||||||||||
Chronic eosinophilic leukemia, not otherwise specified (NOS) | ||||||||||||||||
MPN, unclassifiable | ||||||||||||||||
Mastocytosis |
Other myeloid neoplasm and acute leukemia | Clinical manifestations | Diagnosis | Other features | ||||
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Symptoms | Physical examination | Lab findings | Bone marrow biopsy | Gold standard | Other investigations | ||
Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of
PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2
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Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)
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Myelodysplastic syndromes (MDS)
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Acute myeloid leukemia (AML) and related neoplasms
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Blastic plasmacytoid dendritic cell neoplasm | |||||||
Acute leukemias of ambiguous lineage
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B-lymphoblastic leukemia/lymphoma
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T-lymphoblastic leukemia/lymphoma
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- 50% of patients are asymptomatic
- Clinical features are generally nonspecific such as left upper quadrant pain, early satiety, fatigue & lethargy (most common presenting symptom), weight loss, and night sweats.
- symptoms of anemia
- bleeding
- priapism
- bone pain
- Abdominal mass or fullness
- Infection
- Headache
- Dyspnoea
- Visual disturbances
- Weakness
- Arthralgia
- Cough
- Malaise
- Dizziness
- Nausea/vomiting
- Ankle oedema
- Mental change