Pancreatic cancer causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Pancreatic cancer may be caused by the inactivation of tumor suppressor genes, activation of oncogenes and the deregulation of molecules in various signaling pathways.
Causes
- Pancreatic cancer may be caused by the following: [1] [2] [3]
- Inactivation of tumor suppressor genes
- Activation of oncogenes
- Deregulation of molecules in various signaling pathways
- Inactivation of tumor suppressor genes:
- Tumor suppressor genes may be inactivated by:
- Tumor suppressor genes:
- p53
- p16
- p27CIP1
- BRCA2
- Activation of oncogenes
- Oncogenes may be activated by:
- Oncogenes:
- Ras oncogene
- Cox-2 activation
- Akt-2 gene amplification
- Notch gene
- Cyclin D1
- Deregulation of molecules in various signaling pathways
References
- ↑ Yabar CS, Winter JM (2016). "Pancreatic Cancer: A Review". Gastroenterol Clin North Am. 45 (3): 429–45. doi:10.1016/j.gtc.2016.04.003. PMID 27546841.
- ↑ Ryan DP, Hong TS, Bardeesy N (2014). "Pancreatic adenocarcinoma". N Engl J Med. 371 (11): 1039–49. doi:10.1056/NEJMra1404198. PMID 25207767.
- ↑ Goral V (2015). "Pancreatic Cancer: Pathogenesis and Diagnosis". Asian Pac J Cancer Prev. 16 (14): 5619–24. PMID 26320426.