Chloroprocaine

Chloroprocaine
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]

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Overview

Chloroprocaine is a local anesthetic that is FDA approved for the {{{indicationType}}} of local anesthesia. Common adverse reactions include neurologic: dizziness.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

• Dosage varies with anesthetic procedure, vascularity of tissues, depth of anesthesia, degree of muscle relaxation required, duration of anesthesia, and physical condition of patient
• Local anesthesia: maximum single doses (without epinephrine), 11 mg/kg, not to exceed 800 mg.
• Local anesthesia: maximum single doses (with epinephrine 1:200,000), 14 mg/kg, not to exceed 1000 mg.
• Local anesthesia: (brachial plexus) 30 to 40 mL (600 to 800 mg) as a 2% solution [1]
• Local anesthesia: (caudal epidural) 15 to 25 mL of 2% or 3% methylparaben-free (MPF) solution, repeated every 40-60 min.
• Local anesthesia: (digital, without epinephrine) 3 to 4 mL (30 to 40 mg) as a 1% solution (without epinephrine).
• Local anesthesia: (infraorbital) 0.5 to 1 mL (10 to 20 mg) as a 2% solution.
• Local anesthesia: (lumbar epidural) 2 to 2.5 mL per segment of 2% or 3% methylparaben-free (MPF) solution; usual total volume 15 to 25 mL; repeat doses of 2 to 6 mL less than original dose may be given at 40 to 50 min intervals.
• Local anesthesia: (mandibular) 2 to 3 mL (40 to 60 mg) as a 2% solution.
• Local anesthesia: (paracervical) 3 mL per each of 4 sites as a 1% solution, total dose up to 120 mg.
• Local anesthesia: (pudendal) 10 mL on each side as a 2% solution, total dose 400 mg.

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Chloroprocaine in adult patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Chloroprocaine in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

• Dosage must be individualized based on age and weight of patient.
• Local anesthesia: (infiltration) older than 3 years of age, 0.5% to 1% solution; max 11 mg/kg .
• Local anesthesia: (nerve blocks) older than 3 years of age, 1% to 1.5% solution; max 11 mg/kg .

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

There is limited information about Off-Label Guideline-Supported Use of Chloroprocaine in pediatric patients.

Non–Guideline-Supported Use

There is limited information about Off-Label Non–Guideline-Supported Use of Chloroprocaine in pediatric patients.

Contraindications

• Nesacaine and Nesacaine-MPF Injections are contraindicated in patients hypersensitive (allergic) to drugs of the PABA ester group.
• Lumbar and caudal epidural anesthesia should be used with extreme caution in persons with the following conditions: existing neurological disease, spinal deformities, septicemia, and severe hypertension.

Warnings

There is limited information regarding Chloroprocaine Warnings' in the drug label.

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Chloroprocaine Clinical Trials Experience in the drug label.

Postmarketing Experience

There is limited information regarding Chloroprocaine Postmarketing Experience in the drug label.

Drug Interactions

There is limited information regarding Chloroprocaine Drug Interactions in the drug label.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): There is no FDA guidance on usage of Chloroprocaine in women who are pregnant.
Pregnancy Category (AUS): There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Chloroprocaine in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Chloroprocaine during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Chloroprocaine in women who are nursing.

Pediatric Use

There is no FDA guidance on the use of Chloroprocaine in pediatric settings.

Geriatic Use

There is no FDA guidance on the use of Chloroprocaine in geriatric settings.

Gender

There is no FDA guidance on the use of Chloroprocaine with respect to specific gender populations.

Race

There is no FDA guidance on the use of Chloroprocaine with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Chloroprocaine in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Chloroprocaine in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Chloroprocaine in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Chloroprocaine in patients who are immunocompromised.

Administration and Monitoring

Administration

There is limited information regarding Chloroprocaine Administration in the drug label.

Monitoring

There is limited information regarding Chloroprocaine Monitoring in the drug label.

IV Compatibility

There is limited information regarding the compatibility of Chloroprocaine and IV administrations.

Overdosage

There is limited information regarding Chloroprocaine overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.

Pharmacology

There is limited information regarding Chloroprocaine Pharmacology in the drug label.

Mechanism of Action

There is limited information regarding Chloroprocaine Mechanism of Action in the drug label.

Structure

There is limited information regarding Chloroprocaine Structure in the drug label.

Pharmacodynamics

There is limited information regarding Chloroprocaine Pharmacodynamics in the drug label.

Pharmacokinetics

There is limited information regarding Chloroprocaine Pharmacokinetics in the drug label.

Nonclinical Toxicology

There is limited information regarding Chloroprocaine Nonclinical Toxicology in the drug label.

Clinical Studies

There is limited information regarding Chloroprocaine Clinical Studies in the drug label.

How Supplied

There is limited information regarding Chloroprocaine How Supplied in the drug label.

Storage

There is limited information regarding Chloroprocaine Storage in the drug label.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Chloroprocaine Patient Counseling Information in the drug label.

Precautions with Alcohol

Alcohol-Chloroprocaine interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

There is limited information regarding Chloroprocaine Brand Names in the drug label.

Look-Alike Drug Names

There is limited information regarding Chloroprocaine Look-Alike Drug Names in the drug label.

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.