Quinapril overdosage: Difference between revisions
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==Overdosage== | |||
Doses of 1440 to 4280 mg/kg of quinapril cause significant lethality in mice and rats. | |||
No specific information is available on the treatment of overdosage with quinapril. The most likely clinical manifestation would be symptoms attributable to severe [[hypotension]]. | |||
<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ACCUPRIL (QUINAPRIL HYDROCHLORIDE) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=63cf5651-d52c-4d27-9fd4-ed9cd9724dff | publisher = | date = | accessdate = }}</ref> | Laboratory determinations of serum levels of quinapril and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of quinapril overdose. | ||
No data are available to suggest physiological maneuvers (eg, maneuvers to change pH of the urine) that might accelerate elimination of quinapril and its metabolites. | |||
[[Hemodialysis]] and peritoneal dialysis have little effect on the elimination of quinapril and quinaprilat. [[Angiotensin II]] could presumably serve as a specific antagonist-antidote in the setting of quinapril overdose, but angiotensin II is essentially unavailable outside of scattered research facilities. Because the hypotensive effect of quinapril is achieved through vasodilation and effective [[hypovolemia]], it is reasonable to treat quinapril overdose by infusion of normal saline solution.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ACCUPRIL (QUINAPRIL HYDROCHLORIDE) TABLET, FILM COATED [PARKE-DAVIS DIV OF PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=63cf5651-d52c-4d27-9fd4-ed9cd9724dff | publisher = | date = | accessdate = }}</ref> | |||
Revision as of 16:52, 14 February 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2], Amr Marawan, M.D. [3]
For patient information about Quinapril, click here.
Quinapril
Quinapril and Hydrochlorothiazide tablet
Overview
Quinapril tablet is an angiontensin converting enzyme inhibitor drug that is FDA approved for the treatment of hypertension, heart failure, left ventricular dysfunction after myocardial infarction, diabetic nephropathy. Adverse reactions include hypotension, rash, hyperkalemia, disorder of taste, cough. hypotension, rash, hyperkalemia, disorder of taste, cough.
Category
Antihypertensive Agents, Angiotensin Converting Enzyme Inhibitors. Editor-In-Chief: C. Michael Gibson, M.S., M.D. [4]; Associate Editor(s)-in-Chief: Amr Marawan, M.D. [5]
Overdosage
Doses of 1440 to 4280 mg/kg of quinapril cause significant lethality in mice and rats.
No specific information is available on the treatment of overdosage with quinapril. The most likely clinical manifestation would be symptoms attributable to severe hypotension.
Laboratory determinations of serum levels of quinapril and its metabolites are not widely available, and such determinations have, in any event, no established role in the management of quinapril overdose.
No data are available to suggest physiological maneuvers (eg, maneuvers to change pH of the urine) that might accelerate elimination of quinapril and its metabolites.
Hemodialysis and peritoneal dialysis have little effect on the elimination of quinapril and quinaprilat. Angiotensin II could presumably serve as a specific antagonist-antidote in the setting of quinapril overdose, but angiotensin II is essentially unavailable outside of scattered research facilities. Because the hypotensive effect of quinapril is achieved through vasodilation and effective hypovolemia, it is reasonable to treat quinapril overdose by infusion of normal saline solution.[1]
References
Adapted from the FDA Package Insert.