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| {{CMG}} | | __NOTOC__ |
| | {{Reteplase}} |
| | {{CMG}}; {{AE}} {{AZ}} |
| | ==Interactions=====Drug Interactions=== |
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|
| | The interaction of Retavase® with other cardioactive drugs has not been studied. In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as aspirin, dipyridamole, and abciximab) may increase the risk of bleeding if administered prior to or after Retavase® therapy. |
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| | ===Drug/Laboratory Test Interactions=== |
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| ==Major Interactions==
| | Administration of Retavase® may cause decreases in plasminogen and fibrinogen. During Retavase® therapy, if coagulation tests and/or measurements of fibrinolytic activity are performed, the results may be unreliable unless specific precautions are taken to prevent in vitro artifacts. Retavase® is an enzyme that when present in blood in pharmacologic concentrations remains active under in vitro conditions. This can lead to degradation of fibrinogen in blood samples removed for analysis. Collection of blood samples in the presence of PPACK (chloromethylketone) at 2 µM concentrations was used in clinical trials to prevent in vitro fibrinolytic artifacts.6 |
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| {{refbegin|3}}
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| | |
| * [[abciximab]]
| |
| * [[Acova]]
| |
| * [[Aggrastat]]
| |
| * [[Angiomax]]
| |
| * [[anisindione]]
| |
| * [[Aptivus]]
| |
| * [[ardeparin]]
| |
| * [[argatroban]]
| |
| * [[Arixtra]]
| |
| * [[Arixtra 10 mg/dose]]
| |
| * [[Arixtra 5 mg/dose]]
| |
| * [[Arixtra 7.5 mg/dose]]
| |
| * [[Bexxar Dosimetric]]
| |
| * [[Bexxar I 131 Dosimetric]]
| |
| * [[Bexxar I 131 Therapeutic]]
| |
| * [[BexxarTherapeutic]]
| |
| * [[bivalirudin]]
| |
| * [[Clexane]]
| |
| * [[Clexane Forte]]
| |
| * [[Coumadin]]
| |
| * [[dalteparin]]
| |
| * [[danaparoid]]
| |
| * [[dasatinib]]
| |
| * [[desirudin]]
| |
| * [[dicumarol]]
| |
| * [[drotrecogin]]
| |
| * [[drotrecogin alfa]]
| |
| * [[enoxaparin]]
| |
| * [[eptifibatide]]
| |
| * [[fondaparinux]]
| |
| * [[Fragmin]]
| |
| * [[Hep-Lock]]
| |
| * [[Hep-Pak]]
| |
| * [[Hep-Pak CVC]]
| |
| * [[heparin]]
| |
| * [[Heparin Lock Flush]]
| |
| * [[ibritumomab]]
| |
| * [[In-111 Zevalin]]
| |
| * [[Innohep]]
| |
| * [[Integrilin]]
| |
| * [[iodine I 131 tositumomab]]
| |
| * [[Iprivask]]
| |
| * [[Jantoven]]
| |
| * [[lepirudin]]
| |
| * [[Lovenox]]
| |
| * [[Lovenox HP]]
| |
| * [[Miradon]]
| |
| * [[Normiflo]]
| |
| * [[Orgaran]]
| |
| * [[Refludan]]
| |
| * [[Reopro]]
| |
| * [[Sprycel]]
| |
| * [[tinzaparin]]
| |
| * [[tipranavir]]
| |
| * [[tirofiban]]
| |
| * [[tositumomab]]
| |
| * [[warfarin]]
| |
| * [[Xigris]]
| |
| * [[Y-90 Zevalin]]
| |
| {{refend}}
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| | |
| ==Moderate Interactions==
| |
| | |
| {{refbegin|3}}
| |
| * [[Acetylsalicylic Acid]]
| |
| * [[Actron]]
| |
| * [[Acular]]
| |
| * [[Acular LS]]
| |
| * [[Acular PF]]
| |
| * [[Acuprin 81]]
| |
| * [[Advil]]
| |
| * [[Advil Childrens]]
| |
| * [[Advil Junior Strength]]
| |
| * [[Advil Liquigel]]
| |
| * [[Advil Migraine]]
| |
| * [[Advil Pediatric]]
| |
| * [[Aflaxen]]
| |
| * [[Aleve]]
| |
| * [[Aleve Caplet]]
| |
| * [[Aleve Easy Open Arthritis]]
| |
| * [[Aleve Gelcap]]
| |
| * [[Amigesic]]
| |
| * [[Anaflex]]
| |
| * [[Anafranil]]
| |
| * [[Anaprox]]
| |
| * [[Anaprox-DS]]
| |
| * [[Ansaid]]
| |
| * [[Argesic-SA]]
| |
| * [[Arthritis Pain]]
| |
| * [[Arthropan]]
| |
| * [[ASA]]
| |
| * [[Ascriptin Enteric]]
| |
| * [[Aspergum Cherry]]
| |
| * [[Aspergum Orginal]]
| |
| * [[Aspir-Low]]
| |
| * [[aspirin]]
| |
| * [[aspirin extended release]]
| |
| * [[Aspirin Lite Coat]]
| |
| * [[Aspirin Litecoat]]
| |
| * [[Aspirin Low Strength]]
| |
| * [[Aspirtab]]
| |
| * [[Bayer Aspirin]]
| |
| * [[Bayer Aspirin Regimen]]
| |
| * [[Bayer Aspirin Sugar Free]]
| |
| * [[Bayer Aspirin with Calcium]]
| |
| * [[Bayer Childrens Aspirin]]
| |
| * [[Bayer Low Strength]]
| |
| * [[Bayer Plus]]
| |
| * [[Bayer Select Backache Pain Formula]]
| |
| * [[Bismarex]]
| |
| * [[Bismatrol]]
| |
| * [[Bismatrol Maximum Strength]]
| |
| * [[bismuth subsalicylate]]
| |
| * [[bromfenac]]
| |
| * [[bromfenac ophthalmic]]
| |
| * [[Buffered Aspirin]]
| |
| * [[Bufferin]]
| |
| * [[Bufferin Arthritis Strength]]
| |
| * [[Bufferin Extra Strength]]
| |
| * [[Buffex]]
| |
| * [[Cataflam]]
| |
| * [[Celexa]]
| |
| * [[Ceprotin]]
| |
| * [[Childrens Ibuprofen Berry]]
| |
| * [[Childrens Kaopectate]]
| |
| * [[choline salicylate]]
| |
| * [[citalopram]]
| |
| * [[Clinoril]]
| |
| * [[clomipramine]]
| |
| * [[clopidogrel]]
| |
| * [[Cymbalta]]
| |
| * [[Daypro]]
| |
| * [[desvenlafaxine]]
| |
| * [[dexfenfluramine]]
| |
| * [[diclofenac]]
| |
| * [[diclofenac ophthalmic]]
| |
| * [[diclofenac potassium]]
| |
| * [[diclofenac sodium]]
| |
| * [[diclofenac sodium extended release]]
| |
| * [[diclofenac topical]]
| |
| * [[diflunisal]]
| |
| * [[dipyridamole]]
| |
| * [[Disalcid]]
| |
| * [[Doans Pills]]
| |
| * [[Doans Pills Extra Strength]]
| |
| * [[Dolobid]]
| |
| * [[dong quai]]
| |
| * [[duloxetine]]
| |
| * [[DurAct]]
| |
| * [[Easprin]]
| |
| * [[EC-Naprosyn]]
| |
| * [[Ecotrin]]
| |
| * [[Ecotrin Adult Low Strength]]
| |
| * [[Ecotrin Maximum Strength]]
| |
| * [[Effexor]]
| |
| * [[Effexor XR]]
| |
| * [[Elmiron]]
| |
| * [[Empirin]]
| |
| * [[Entaprin]]
| |
| * [[Entercote]]
| |
| * [[escitalopram]]
| |
| * [[etodolac]]
| |
| * [[etodolac extended release]]
| |
| * [[Extra Strength Bayer]]
| |
| * [[Fasprin]]
| |
| * [[Feldene]]
| |
| * [[fenfluramine]]
| |
| * [[fenoprofen]]
| |
| * [[Flector Patch]]
| |
| * [[fluoxetine]]
| |
| * [[fluoxetine extended release]]
| |
| * [[flurbiprofen]]
| |
| * [[flurbiprofen ophthalmic]]
| |
| * [[fluvoxamine]]
| |
| * [[fluvoxamine extended release]]
| |
| * [[garlic]]
| |
| * [[Garlic Oil]]
| |
| * [[Genacote]]
| |
| * [[Gennin-FC]]
| |
| * [[Genpril]]
| |
| * [[Genprin]]
| |
| * [[ginger]]
| |
| * [[Ginger Root]]
| |
| * [[Ginger(obs)]]
| |
| * [[gingko]]
| |
| * [[gingko biloba]]
| |
| * [[ginseng]]
| |
| * [[Halfprin]]
| |
| * [[Haltran]]
| |
| * [[hemin]]
| |
| * [[Hofels Ginger One A Day]]
| |
| * [[Ibu]]
| |
| * [[IBU-200]]
| |
| * [[Ibu-4]]
| |
| * [[Ibu-6]]
| |
| * [[Ibu-8]]
| |
| * [[Ibu-Tab]]
| |
| * [[ibuprofen]]
| |
| * [[Ibuprofen PMR]]
| |
| * [[iloprost]]
| |
| * [[Indocin]]
| |
| * [[Indocin SR]]
| |
| * [[indomethacin]]
| |
| * [[indomethacin extended release]]
| |
| * [[K-Pek]]
| |
| * [[Kao-Tin Bismuth Subsalicylate Formula]]
| |
| * [[Kaopectate]]
| |
| * [[Kaopectate Anti-Diarrheal Upset Stomach Reliever]]
| |
| * [[Kaopectate Extra Strength]]
| |
| * [[Kapectolin (New Formula)]]
| |
| * [[ketoprofen]]
| |
| * [[ketoprofen extended release]]
| |
| * [[ketorolac]]
| |
| * [[ketorolac ophthalmic]]
| |
| * [[Leader Naproxen Sodium]]
| |
| * [[Lexapro]]
| |
| * [[Litecoat Aspirin]]
| |
| * [[Lodine]]
| |
| * [[Lodine XL]]
| |
| * [[Low Dose ASA]]
| |
| * [[Luvox]]
| |
| * [[Luvox CR]]
| |
| * [[Maalox Total Stomach Relief]]
| |
| * [[Magan]]
| |
| * [[magnesium salicylate]]
| |
| * [[Marthritic]]
| |
| * [[Maximum Strength Stress]]
| |
| * [[meclofenamate]]
| |
| * [[Meclomen]]
| |
| * [[mefenamic acid]]
| |
| * [[meloxicam]]
| |
| * [[Menadol]]
| |
| * [[Meridia]]
| |
| * [[Midol Extended Relief]]
| |
| * [[Midol IB]]
| |
| * [[Midol Maximum Strength Cramp Formula]]
| |
| * [[Minitabs]]
| |
| * [[Mobic]]
| |
| * [[Mobidin]]
| |
| * [[Mono-Gesic]]
| |
| * [[Motrin]]
| |
| * [[Motrin Childrens]]
| |
| * [[Motrin IB]]
| |
| * [[Motrin Infant Drops]]
| |
| * [[Motrin Junior Strength]]
| |
| * [[Motrin Migraine Pain]]
| |
| * [[MST]]
| |
| * [[nabumetone]]
| |
| * [[Nalfon]]
| |
| * [[Naprelan '375']]
| |
| * [[Naprelan '500']]
| |
| * [[Naprosyn]]
| |
| * [[naproxen]]
| |
| * [[naproxen sodium]]
| |
| * [[Naproxen Sodium DS]]
| |
| * [[naproxen sodium extended release]]
| |
| * [[NeoProfen]]
| |
| * [[nepafenac ophthalmic]]
| |
| * [[Nevanac]]
| |
| * [[Norwich Aspirin]]
| |
| * [[Nuprin]]
| |
| * [[Nuprin Backache Caplet]]
| |
| * [[Ocufen]]
| |
| * [[Orudis]]
| |
| * [[Orudis KT]]
| |
| * [[Oruvail]]
| |
| * [[oxaprozin]]
| |
| * [[Panhematin]]
| |
| * [[paroxetine]]
| |
| * [[paroxetine extended release]]
| |
| * [[paroxetine mesylate]]
| |
| * [[Paxil]]
| |
| * [[Paxil CR]]
| |
| * [[Pediacare Fever]]
| |
| * [[pentosan polysulfate sodium]]
| |
| * [[Peptic Relief]]
| |
| * [[Pepto-Bismol]]
| |
| * [[Pepto-Bismol Maximum Strength]]
| |
| * [[Persantine]]
| |
| * [[Persantine IV]]
| |
| * [[Pexeva]]
| |
| * [[phenyl salicylate]]
| |
| * [[phenylbutazone]]
| |
| * [[Pink Bismuth]]
| |
| * [[piroxicam]]
| |
| * [[Plavix]]
| |
| * [[Pondimin]]
| |
| * [[Ponstel]]
| |
| * [[Pristiq]]
| |
| * [[protein C]]
| |
| * [[Protexel]]
| |
| * [[Prozac]]
| |
| * [[Prozac Weekly]]
| |
| * [[Q-Profen]]
| |
| * [[Rapiflux]]
| |
| * [[Redux]]
| |
| * [[Relafen]]
| |
| * [[Remodulin]]
| |
| * [[Rexolate]]
| |
| * [[Rufen]]
| |
| * [[Saleto-200]]
| |
| * [[Saleto-400]]
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| * [[Saleto-600]]
| |
| * [[Saleto-800]]
| |
| * [[Salflex]]
| |
| * [[salsalate]]
| |
| * [[Salsitab]]
| |
| * [[Sarafem]]
| |
| * [[Selfemra]]
| |
| * [[sertraline]]
| |
| * [[sibutramine]]
| |
| * [[Sloprin]]
| |
| * [[sodium salicylate]]
| |
| * [[sodium thiosalicylate]]
| |
| * [[Solaraze]]
| |
| * [[St. Joseph Aspirin]]
| |
| * [[St. Joseph Aspirin Adult Chewable]]
| |
| * [[St. Joseph Aspirin Adult EC]]
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| * [[Stanback Analgesic]]
| |
| * [[Stress Maximum Strength]]
| |
| * [[sulindac]]
| |
| * [[suprofen ophthalmic]]
| |
| * [[Therapy Bayer]]
| |
| * [[Ticlid]]
| |
| * [[ticlopidine]]
| |
| * [[Tolectin]]
| |
| * [[Tolectin 600]]
| |
| * [[Tolectin DS]]
| |
| * [[tolmetin]]
| |
| * [[Toradol]]
| |
| * [[Toradol IM]]
| |
| * [[Toradol IV/IM]]
| |
| * [[treprostinil]]
| |
| * [[Tri-Buffered Aspirin]]
| |
| * [[Tusal]]
| |
| * [[venlafaxine]]
| |
| * [[venlafaxine extended release]]
| |
| * [[Ventavis]]
| |
| * [[Voltaren]]
| |
| * [[Voltaren Ophthalmic]]
| |
| * [[Voltaren Topical]]
| |
| * [[Voltaren-XR]]
| |
| * [[Xibrom]]
| |
| * [[YSP Aspirin]]
| |
| * [[Zero-Order Release]]
| |
| * [[zingiber]]
| |
| * [[Zoloft]]
| |
| * [[Zorprin]]
| |
| {{refend}}
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| | |
| ==Minor Interactions==
| |
| | |
| {{refbegin|3}}
| |
| * [[capsaicin]]
| |
| * [[capsicum]]
| |
| * [[chamomile]]
| |
| * [[clove]]
| |
| * [[fenugreek]]
| |
| * [[feverfew]]
| |
| * [[matricaria]]
| |
| * [[turmeric]]
| |
| {{refend}}
| |
|
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|
| | ===Use of Antithrombotics=== |
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|
| | Heparin and aspirin have been administered concomitantly with and following the administration of Retavase® in the management of acute myocardial infarction. Because heparin, aspirin, or Retavase® may cause bleeding complications, careful monitoring for bleeding is advised, especially at arterial puncture sites. |
| | <ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = RETAVASE (RETEPLASE) KIT [EKR THERAPEUTICS, INC.] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e9ae6656-977c-4105-8528-bee664aab27a | publisher = | date = | accessdate = }}</ref> |
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| | ==References== |
| | {{Reflist}} |
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| {{FDA}} | | {{FDA}} |
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| [[Category:Drugs]] | | [[Category:Drugs]] |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Zaghw, M.D. [2]
Interactions=====Drug Interactions=
The interaction of Retavase® with other cardioactive drugs has not been studied. In addition to bleeding associated with heparin and vitamin K antagonists, drugs that alter platelet function (such as aspirin, dipyridamole, and abciximab) may increase the risk of bleeding if administered prior to or after Retavase® therapy.
Drug/Laboratory Test Interactions
Administration of Retavase® may cause decreases in plasminogen and fibrinogen. During Retavase® therapy, if coagulation tests and/or measurements of fibrinolytic activity are performed, the results may be unreliable unless specific precautions are taken to prevent in vitro artifacts. Retavase® is an enzyme that when present in blood in pharmacologic concentrations remains active under in vitro conditions. This can lead to degradation of fibrinogen in blood samples removed for analysis. Collection of blood samples in the presence of PPACK (chloromethylketone) at 2 µM concentrations was used in clinical trials to prevent in vitro fibrinolytic artifacts.6
Use of Antithrombotics
Heparin and aspirin have been administered concomitantly with and following the administration of Retavase® in the management of acute myocardial infarction. Because heparin, aspirin, or Retavase® may cause bleeding complications, careful monitoring for bleeding is advised, especially at arterial puncture sites.
[1]
References
Adapted from the FDA Package Insert.