Zidovudine drug interactions: Difference between revisions
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===Hematologic/Bone Marrow Suppressive/Cytotoxic Agents=== | ===Hematologic/Bone Marrow Suppressive/Cytotoxic Agents=== | ||
Coadministration of ganciclovir, interferon alfa, ribavirin, and other bone marrow suppressive or cytotoxic agents may increase the hematologic toxicity of zidovudine.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = RETROVIR (ZIDOVUDINE) CAPSULE RETROVIR (ZIDOVUDINE) TABLET, FILM COATED RETROVIR (ZIDOVUDINE) SYRUP [VIIV HEALTHCARE COMPANY] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6df09f15-b102-431c-adde-d7aeef6f5d84 | publisher = | date = | accessdate = 9 January 2014 }}</ref> | Coadministration of [[ganciclovir]], interferon alfa, [[ribavirin]], and other bone marrow suppressive or cytotoxic agents may increase the hematologic toxicity of zidovudine.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = RETROVIR (ZIDOVUDINE) CAPSULE RETROVIR (ZIDOVUDINE) TABLET, FILM COATED RETROVIR (ZIDOVUDINE) SYRUP [VIIV HEALTHCARE COMPANY] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=6df09f15-b102-431c-adde-d7aeef6f5d84 | publisher = | date = | accessdate = 9 January 2014 }}</ref> | ||
==References== | ==References== | ||
Latest revision as of 18:55, 9 January 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]
Drug Interactions
Antiretroviral Agents
Stavudine: Concomitant use of zidovudine with stavudine should be avoided since an antagonistic relationship has been demonstrated in vitro.
Nucleoside Analogues Affecting DNA Replication: Some nucleoside analogues affecting DNA replication, such as ribavirin, antagonize the in vitro antiviral activity of RETROVIR against HIV-1; concomitant use of such drugs should be avoided.
Doxorubicin
Concomitant use of zidovudine with doxorubicin should be avoided since an antagonistic relationship has been demonstrated in vitro.
Hematologic/Bone Marrow Suppressive/Cytotoxic Agents
Coadministration of ganciclovir, interferon alfa, ribavirin, and other bone marrow suppressive or cytotoxic agents may increase the hematologic toxicity of zidovudine.[1]
References
Adapted from the FDA Package Insert.