Renal artery stenosis pathophysiology: Difference between revisions
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The [[macula densa]] of the kidney senses a decreased systemic blood pressure due to the pressure drop over the stenosis. The response of the kidney to this decreased blood pressure is activation of the [[renin-angiotension aldosterone system]], which normally counteracts low blood pressure, but in this case lead to hypertension (high blood pressure). The decreased perfusion pressure (caused by the stenosis) leads to decreased blood flow ([[hypoperfusion]]) to the kidney and a decrease in the [[Glomerular filtration rate|GFR]]. If the stenosis is long standing and severe the GFR in the affected kidneys never increases again and (pre-renal) [[renal failure]] is the result. | The [[macula densa]] of the kidney senses a decreased systemic blood pressure due to the pressure drop over the stenosis. The response of the kidney to this decreased blood pressure is activation of the [[renin-angiotension aldosterone system]], which normally counteracts low blood pressure, but in this case lead to hypertension (high blood pressure). The decreased perfusion pressure (caused by the stenosis) leads to decreased blood flow ([[hypoperfusion]]) to the kidney and a decrease in the [[Glomerular filtration rate|GFR]]. If the stenosis is long standing and severe the GFR in the affected kidneys never increases again and (pre-renal) [[renal failure]] is the result. | ||
[[Image:Renal artery stenosis diagram 001.gif | [[Image:Renal artery stenosis diagram 001.gif|200px|Illustration of renal artery stenosis]] | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 21:42, 8 January 2014
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Overview
Pathophysiology
The macula densa of the kidney senses a decreased systemic blood pressure due to the pressure drop over the stenosis. The response of the kidney to this decreased blood pressure is activation of the renin-angiotension aldosterone system, which normally counteracts low blood pressure, but in this case lead to hypertension (high blood pressure). The decreased perfusion pressure (caused by the stenosis) leads to decreased blood flow (hypoperfusion) to the kidney and a decrease in the GFR. If the stenosis is long standing and severe the GFR in the affected kidneys never increases again and (pre-renal) renal failure is the result.