Minimal change disease classification: Difference between revisions
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{{Minimal change disease}} | {{Minimal change disease}} | ||
===Clinical Classification=== | |||
The clinical classification of minimal change disease is based on the underlying etiology of the disease. | |||
====Primary==== | |||
In primary (idiopathic) cases, the underlying cause is not known. | |||
====Secondary==== | |||
Secondary forms of minimal change disease are associated with certain environmental exposures, such as allergies (bee sting), malignancies (lymphomas and leukemias), medications (NSAID, penicillamine, ampicillin), and other toxins (gold, mercury) | |||
===Pathological Classification=== | |||
Minimal change disease currently has no classification system. Early observations noted that a small number of patients with minimal change disease have focal tip lesions.<ref name="pmid12046027">{{cite journal| author=Haas M, Yousefzadeh N| title=Glomerular tip lesion in minimal change nephropathy: a study of autopsies before 1950. | journal=Am J Kidney Dis | year= 2002 | volume= 39 | issue= 6 | pages= 1168-75 | pmid=12046027 | doi=10.1053/ajkd.2002.33386 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12046027 }} </ref> Based on a proposed Columbia classification by D’Agati and colleagues<ref name="pmid14750104">{{cite journal| author=D'Agati VD, Fogo AB, Bruijn JA, Jennette JC| title=Pathologic classification of focal segmental glomerulosclerosis: a working proposal. | journal=Am J Kidney Dis | year= 2004 | volume= 43 | issue= 2 | pages= 368-82 | pmid=14750104 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=14750104 }} </ref> in 2004, MCD was considered an entity within the spectrum of the focal segmental glomerulonephritis (FSGS) and may have a clinical course similar to those with “tip lesion” subtype of FSGS. | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
Revision as of 03:57, 25 November 2013
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Clinical Classification
The clinical classification of minimal change disease is based on the underlying etiology of the disease.
Primary
In primary (idiopathic) cases, the underlying cause is not known.
Secondary
Secondary forms of minimal change disease are associated with certain environmental exposures, such as allergies (bee sting), malignancies (lymphomas and leukemias), medications (NSAID, penicillamine, ampicillin), and other toxins (gold, mercury)
Pathological Classification
Minimal change disease currently has no classification system. Early observations noted that a small number of patients with minimal change disease have focal tip lesions.[1] Based on a proposed Columbia classification by D’Agati and colleagues[2] in 2004, MCD was considered an entity within the spectrum of the focal segmental glomerulonephritis (FSGS) and may have a clinical course similar to those with “tip lesion” subtype of FSGS.
References
- ↑ Haas M, Yousefzadeh N (2002). "Glomerular tip lesion in minimal change nephropathy: a study of autopsies before 1950". Am J Kidney Dis. 39 (6): 1168–75. doi:10.1053/ajkd.2002.33386. PMID 12046027.
- ↑ D'Agati VD, Fogo AB, Bruijn JA, Jennette JC (2004). "Pathologic classification of focal segmental glomerulosclerosis: a working proposal". Am J Kidney Dis. 43 (2): 368–82. PMID 14750104.