Minimal change disease: Difference between revisions

	Minimal Change Disease Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Minimal Change Disease from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Diagnostic Study of Choice
History and Symptoms
Physical Examination
Laboratory Findings
Immunohistology
Electron Microscopy
Electrocardiogram
X-ray
Echocardiorgaphy or Ultrasound
CT scan
MRI
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Minimal change disease On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Minimal change disease All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Minimal change disease
CDC on Minimal change disease
Minimal change disease in the news
Blogs on Minimal change disease
Directions to Hospitals Treating Minimal change disease
Risk calculators and risk factors for Minimal change disease

VisualWikitext

Revision as of 14:47, 28 September 2012

Template:DiseaseDisorder infobox For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief:’’’ Cafer Zorkun, M.D., Ph.D. [2]

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Minimal change disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Treatment

Case Studies

Case #1

Template:Nephrology sv:Minimal change disease

Template:WikiDoc Sources

@@ Line 20: / Line 20: @@
-==Overview==
+==[[Minimal change disease overview|Overview]]==
-'''Minimal change disease''' or ''nil disease'' (lipoid nephrosis) is a disease of the [[kidney]] which causes [[nephrotic syndrome]] and usually affects children (peak incidence at 2-3 years of age).<ref name=Robbins_2005>{{cite book | author = Kumar V, Fausto N, Abbas A (editors) | title = Robbins & Cotran Pathologic Basis of Disease | edition = 7th | pages=pp. 981-2 | publisher = Saunders | year = 2003 | id = ISBN 978-0-721-60187-8 }}</ref>
+==[[Minimal change disease historical perspective|Historical Perspective]]==
-==Symptoms==
+==[[Minimal change disease classification|Classification]]==
-The symptoms are [[proteinuria]] (leakage of protein into the urine) and [[water retention]].  There are other kidney diseases that have these same symptoms but a [[needle biopsy]] shows change in the kidney tissue if these other diseases are present.
-==Causes==
+==[[Minimal change disease pathophysiology|Pathophysiology]]==
-Minimal change disease can be associated with food allergies, medications, or hematologic malignancies, or it can occur [[idiopathic|idiopathically]]. The pathology does not appear to involve complement, [[Antibody|immunoglobulins]], or immune complex deposition. Rather, an altered cell-mediated immunologic response with abnormal secretion of [[lymphokine]]s by [[T cell]]s is thought to reduce the production of anions in the [[glomerular basement membrane]], thereby increasing the glomerular permeability to [[serum albumin]] through a reduction of electrostatic repulsion.<ref name=Mathieson_2003>{{cite journal |author=Mathieson P |title=Immune dysregulation in minimal change nephropathy |journal=Nephrol Dial Transplant |volume=18 Suppl 6 |issue= |pages=vi26-9 |year=2003 |pmid=12953038}}</ref> The loss of [[Anion|anionic]] charges is also thought to favor foot process fusion.  With minimal change disease the kidney tissue appears normal under a light microscope, but shows [[podocyte]] foot process effacement under an [[Electron microscopy|electron microscope]].<ref name=Robbins_2005 />
-==Treatment==
+==[[Minimal change disease causes|Causes]]==
-[[Prednisone]] is prescribed along with a blood pressure medication, typically an [[ACE inhibitor]] such as [[lisinopril]].  Often the liver is overactive with minimal change disease and over produces [[cholesterol]].  Therefore a [[statin]] drug is often prescribed for the duration of the treatment.  When the urine is clear of protein, the drugs can be discontinued. 50% of patients will relapse and need further treatment.
+==[[Minimal change disease differential diagnosis|Differentiating Minimal change disease from other Diseases]]==
+==[[Minimal change disease epidemiology and demographics|Epidemiology and Demographics]]==
+==[[Minimal change disease risk factors|Risk Factors]]==
+==[[Minimal change disease screening|Screening]]==
+==[[Minimal change disease natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
-==Other notes==
+==Diagnosis==
-% of those who get minimal change disease have a recurrence with 20% never realizing another occurrence.  Some authors have noted that other conditions associated with T-cell abnormalities, such as [[Hodgkin's disease]] and [[T-cell lymphoma]], are sometimes associated with minimal change disease.
+[[Minimal change disease staging|Staging]] | [[Minimal change disease history and symptoms|History and Symptoms]] | [[Minimal change disease physical examination|Physical Examination]] | [[Minimal change disease laboratory findings|Laboratory Findings]] | [[Minimal change disease chest x ray|Chest X Ray]] | [[Minimal change disease CT|CT]] | [[Minimal change disease MRI|MRI]] | [[Minimal change disease other imaging findings|Other Imaging Findings]] | [[Minimal change disease other diagnostic studies|Other Diagnostic Studies]]
-==External links==
+==Treatment==
+[[Minimal change disease medical therapy|Medical Therapy]] | [[Minimal change disease surgery|Surgery]] | [[Minimal change disease primary prevention|Primary Prevention]] | [[Minimal change disease secondary prevention|Secondary Prevention]] | [[Minimal change disease cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] |  [[Minimal change disease future or investigational therapies|Future or Investigational Therapies]]
-* [http://www.kidcomm.org Kidcomm] - An online resource for parents dealing with childhood kidney diseases
+==Case Studies==
-* [http://www.kidney.org National Kidney Foundation]
-==References==
+[[Minimal change disease case study one|Case #1]]
-{{Reflist|2}}

Minimal change disease: Difference between revisions

Revision as of 14:47, 28 September 2012

Diagnosis

Treatment

Case Studies

Navigation menu