Babesiosis: Difference between revisions

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==Treatment==
==Treatment==
[[Babesiosis medical therapy|Medical therapy]] | [[Babesiosis surgery|Surgical options]] | [[Babesiosis primary prevention|Primary prevention]]  | [[Babesiosis secondary prevention|Secondary prevention]] | [[Babesiosis cost-effectiveness of therapy|Financial costs]] | [[Babesiosis future or investigational therapies|Future therapies]]
[[Babesiosis medical therapy|Medical therapy]] | [[Babesiosis surgery|Surgical options]] | [[Babesiosis primary prevention|Primary prevention]]  | [[Babesiosis secondary prevention|Secondary prevention]] | [[Babesiosis cost-effectiveness of therapy|Financial costs]] | [[Babesiosis future or investigational therapies|Future therapies]]
==Pathophysiology==
''Babesia'' parasites reproduce in [[red blood cell]]s, where they can be seen as cross-shaped inclusions (4 [[merozoite]]s asexually budding but attached together forming a structure looking like a "Maltese Cross") and cause [[hemolytic anemia]], quite similar to [[malaria]].
Note that unlike the ''[[Plasmodium]]'' parasites that cause malaria, ''Babesia'' species lack an exo-erythrotic phase, so the liver is usually not affected.


==Diagnosis==
==Diagnosis==

Revision as of 17:02, 23 January 2012

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Historical Perspective

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Epidemiology & Demographics

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Complications & Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory tests | Electrocardiogram | X Rays | CT | MRI Echocardiography or Ultrasound | Other images | Alternative diagnostics

Treatment

Medical therapy | Surgical options | Primary prevention | Secondary prevention | Financial costs | Future therapies

Diagnosis

Babesiosis is easy to diagnose but only if it is suspected. It will not show up on any routine tests. It must be suspected when a persons with exposure in an endemic area develops persistent fevers and hemolytic anemia. Babesiosis can be diagnosed by direct examination of the blood (see photo), with serology, or with PCR-based tests. Other laboratory findings include decreased numbers of red blood cells and platelets on complete blood count.

Treatment

Most cases of babesiosis resolve without any specific treatment. For ill patients, treatment is usually a two-drug regimen. The traditional regimen of quinine and clindamycin is often poorly tolerated; recent evidence suggests that a regimen of atovaquone and azithromycin can be equally effective [1]. In life-threatening cases, exchange transfusion is performed. In this procedure, the infected red blood cells are removed and replaced with fresh ones.

References

  • Herwaldt BL, Persing DH, Précigout EA, et al. A fatal case of babesiosis in Missouri: Identification of another piroplasm that infect humans. Ann Intern Med 1996;124:643-65.
  • Pershing DH, Herwaldt BL, Glaser C, et al. Infection with a Babesia-like organism in northern California. N Engl J Med 1995;332:298-303.
  1. Krause P, Lepore T, Sikand V, Gadbaw J, Burke G, Telford S, Brassard P, Pearl D, Azlanzadeh J, Christianson D, McGrath D, Spielman A (2000). "Atovaquone and azithromycin for the treatment of babesiosis". N Engl J Med. 343 (20): 1454–8. PMID 11078770.

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