Extramammary Paget's disease: Difference between revisions

Jump to navigation Jump to search
mNo edit summary
Line 23: Line 23:
'''Extramammary Paget’s disease''' ('''EMPD'''), also '''Extramammary Paget disease''', is a usually non-invasive [[adenocarcinoma]] of the [[skin]] outside of the [[mammary gland]]  and includes ''Paget's disease of the [[vulva]]'' and ''Paget's disease of the [[penis]]''. The origin of the neoplastic cells could be [[apocrine gland]]s or epithelial [[stem cells]]. Skin areas rich in apocrine glands such as the genital region are typical sites of EMPD.  
'''Extramammary Paget’s disease''' ('''EMPD'''), also '''Extramammary Paget disease''', is a usually non-invasive [[adenocarcinoma]] of the [[skin]] outside of the [[mammary gland]]  and includes ''Paget's disease of the [[vulva]]'' and ''Paget's disease of the [[penis]]''. The origin of the neoplastic cells could be [[apocrine gland]]s or epithelial [[stem cells]]. Skin areas rich in apocrine glands such as the genital region are typical sites of EMPD.  


==Signs and symptoms==
==History==
Signs and symptoms are a skin lesion often mistaken as an [[eczema]] that may be [[itch]]y or painful. A [[biopsy]] will establish the diagnosis. The histology of the lesion is the same as for [[Paget's disease of the breast]].
[[James Paget]] had described Paget disease of the nipple in 1874. Radcliffe Crocker reported the first case of EMPD in 1889 when he described a patient with a skin lesion affecting the penis and scrotum the findings of which were identical to those described by Paget. EMPD is found in a number of locations where apocrine glands are common.


==Types==
==Types==
Line 34: Line 34:
It is important to exclude that the lesion is associated with another cancer. Primary disease is usually treated by surgical excision.
It is important to exclude that the lesion is associated with another cancer. Primary disease is usually treated by surgical excision.


==History==
==Signs and symptoms==
[[James Paget]] had described Paget disease of the nipple in 1874. Radcliffe Crocker reported the first case of EMPD in 1889 when he described a patient with a skin lesion affecting the penis and scrotum the findings of which were identical to those described by Paget. EMPD is found in a number of locations where apocrine glands are common.
Signs and symptoms are a skin lesion often mistaken as an [[eczema]] that may be [[itch]]y or painful. A [[biopsy]] will establish the diagnosis. The histology of the lesion is the same as for [[Paget's disease of the breast]].


==See also==
==See also==
* [[Paget's disease of the breast]]
* [[Paget's disease of the breast]]
==External links==
* [http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_vulvar_cancer_45.asp Definition] at cancer.org


{{Epithelial neoplasms}}
{{Epithelial neoplasms}}
{{SIB}}
{{SIB}}
[[Category:Disease state]]
[[Category:Dermatology]]
[[Category:Dermatology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]

Revision as of 13:01, 31 July 2011

For patient information click here

Extramammary Paget's disease
ICD-O: M8542/3

WikiDoc Resources for Extramammary Paget's disease

Articles

Most recent articles on Extramammary Paget's disease

Most cited articles on Extramammary Paget's disease

Review articles on Extramammary Paget's disease

Articles on Extramammary Paget's disease in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Extramammary Paget's disease

Images of Extramammary Paget's disease

Photos of Extramammary Paget's disease

Podcasts & MP3s on Extramammary Paget's disease

Videos on Extramammary Paget's disease

Evidence Based Medicine

Cochrane Collaboration on Extramammary Paget's disease

Bandolier on Extramammary Paget's disease

TRIP on Extramammary Paget's disease

Clinical Trials

Ongoing Trials on Extramammary Paget's disease at Clinical Trials.gov

Trial results on Extramammary Paget's disease

Clinical Trials on Extramammary Paget's disease at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Extramammary Paget's disease

NICE Guidance on Extramammary Paget's disease

NHS PRODIGY Guidance

FDA on Extramammary Paget's disease

CDC on Extramammary Paget's disease

Books

Books on Extramammary Paget's disease

News

Extramammary Paget's disease in the news

Be alerted to news on Extramammary Paget's disease

News trends on Extramammary Paget's disease

Commentary

Blogs on Extramammary Paget's disease

Definitions

Definitions of Extramammary Paget's disease

Patient Resources / Community

Patient resources on Extramammary Paget's disease

Discussion groups on Extramammary Paget's disease

Patient Handouts on Extramammary Paget's disease

Directions to Hospitals Treating Extramammary Paget's disease

Risk calculators and risk factors for Extramammary Paget's disease

Healthcare Provider Resources

Symptoms of Extramammary Paget's disease

Causes & Risk Factors for Extramammary Paget's disease

Diagnostic studies for Extramammary Paget's disease

Treatment of Extramammary Paget's disease

Continuing Medical Education (CME)

CME Programs on Extramammary Paget's disease

International

Extramammary Paget's disease en Espanol

Extramammary Paget's disease en Francais

Business

Extramammary Paget's disease in the Marketplace

Patents on Extramammary Paget's disease

Experimental / Informatics

List of terms related to Extramammary Paget's disease

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Extramammary Paget’s disease (EMPD), also Extramammary Paget disease, is a usually non-invasive adenocarcinoma of the skin outside of the mammary gland and includes Paget's disease of the vulva and Paget's disease of the penis. The origin of the neoplastic cells could be apocrine glands or epithelial stem cells. Skin areas rich in apocrine glands such as the genital region are typical sites of EMPD.

History

James Paget had described Paget disease of the nipple in 1874. Radcliffe Crocker reported the first case of EMPD in 1889 when he described a patient with a skin lesion affecting the penis and scrotum the findings of which were identical to those described by Paget. EMPD is found in a number of locations where apocrine glands are common.

Types

Paget's disease of the vulva may be a primary lesion or associated with adenocarcinoma originating from local organs such as the Bartholin gland, the urethra, or the rectum and thus be secondary. Patients tend to be in the postmenopausal range.

Paget's disease of the penis may also be primary or secondary and is less common than genital Paget’s disease in women.

Primary disease

It is important to exclude that the lesion is associated with another cancer. Primary disease is usually treated by surgical excision.

Signs and symptoms

Signs and symptoms are a skin lesion often mistaken as an eczema that may be itchy or painful. A biopsy will establish the diagnosis. The histology of the lesion is the same as for Paget's disease of the breast.

See also

Template:Epithelial neoplasms Template:SIB


Template:WikiDoc Sources