Gangrene pathophysiology: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 2: Line 2:
{{Gangrene}}
{{Gangrene}}
{{CMG}}{{AE}} [[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]]
{{CMG}}{{AE}} [[User:Edzelco|Edzel Lorraine Co, D.M.D., M.D.]]
==Overview==
The three main types of [[gangrene]] occur in different mechanisms. [[Dry gangrene]] involves a reduction in the [[perfusion]] of the [[arteries]] results in the compensatory dilation of the [[arterioles]], which eventually results in [[distal]] [[edema]], and damage of the [[endothelial tissue]].<ref name="pmid32809387">{{cite journal| author=| title=StatPearls | journal= | year= 2022 | volume=  | issue=  | pages=  | pmid=32809387 | doi= | pmc= | url= }} </ref> In [[wet gangrene]], [[saprogenic]] [[microorganisms]] (''[[Bacillus fusiformis]]'', or ''[[Clostridium perfringens]]'') infect the [[tissues]], thereby causing an emission of a foul odor and [[edema]]. <ref name="pmid29910628">{{cite journal| author=Al Wahbi A| title=Autoamputation of diabetic toe with dry gangrene: a myth or a fact? | journal=Diabetes Metab Syndr Obes | year= 2018 | volume= 11 | issue=  | pages= 255-264 | pmid=29910628 | doi=10.2147/DMSO.S164199 | pmc=5987754 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29910628  }} </ref> Multiplication of [[exotoxins]] from ''[[Clostridium perfringens]]'' and [[group A steptococcus]] is responsible for the local [[tissue]] destruction and [[systemic infection]] in [[gas gangrene]].<ref name="pmid1884064">{{cite journal| author=Lehner PJ, Powell H| title=Gas gangrene. | journal=BMJ | year= 1991 | volume= 303 | issue= 6796 | pages= 240-2 | pmid=1884064 | doi=10.1136/bmj.303.6796.240 | pmc=1670510 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1884064  }} </ref>
==Pathophysiology==
==Pathophysiology==
===Dry Gangrene===
===Dry Gangrene===
Line 10: Line 13:


===Gas Gangrene===
===Gas Gangrene===


==References==
==References==

Revision as of 05:49, 6 April 2022

Gangrene Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Gangrene from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

X Ray

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Case #1

Gangrene pathophysiology On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Gangrene pathophysiology

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Gangrene pathophysiology

CDC on Gangrene pathophysiology

Gangrene pathophysiology in the news

Blogs on Gangrene pathophysiology

Directions to Hospitals Treating Gangrene

Risk calculators and risk factors for Gangrene pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Edzel Lorraine Co, D.M.D., M.D.

Overview

The three main types of gangrene occur in different mechanisms. Dry gangrene involves a reduction in the perfusion of the arteries results in the compensatory dilation of the arterioles, which eventually results in distal edema, and damage of the endothelial tissue.[1] In wet gangrene, saprogenic microorganisms (Bacillus fusiformis, or Clostridium perfringens) infect the tissues, thereby causing an emission of a foul odor and edema. [2] Multiplication of exotoxins from Clostridium perfringens and group A steptococcus is responsible for the local tissue destruction and systemic infection in gas gangrene.[3]

Pathophysiology

Dry Gangrene

Wet Gangrene

Gas Gangrene

References

  1. "StatPearls". 2022. PMID 32809387 Check |pmid= value (help).
  2. Al Wahbi A (2018). "Autoamputation of diabetic toe with dry gangrene: a myth or a fact?". Diabetes Metab Syndr Obes. 11: 255–264. doi:10.2147/DMSO.S164199. PMC 5987754. PMID 29910628.
  3. Lehner PJ, Powell H (1991). "Gas gangrene". BMJ. 303 (6796): 240–2. doi:10.1136/bmj.303.6796.240. PMC 1670510. PMID 1884064.

Template:WH

Template:WS