Autoimmune lymphoproliferative syndrome physical examination: Difference between revisions

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*[[Splenomegaly]]: >80% of patients present with clinically identifiable splenomegaly.  It can be massive.
*[[Splenomegaly]]: >80% of patients present with clinically identifiable splenomegaly.  It can be massive.
*[[Hepatomegaly]]: 30-40% of patients have enlarged livers.
*[[Hepatomegaly]]: 30-40% of patients have enlarged livers.
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*
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Revision as of 19:06, 26 June 2021

Autoimmune lymphoproliferative syndrome Microchapters

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Autoimmune lymphoproliferative syndrome from other Diseases

Epidemiology and Demographics

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Natural History, Complications and Prognosis

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History and Symptoms

Physical Examination

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Editor-In-Chief: David Teachey, MD [1]

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Overview

Common physical examination findings of Autoimmune lymphoproliferative syndrome(ALPS) include lymphadenopathy, Hepatomegaly, or splenomegaly. The majority of patients(80%) have enlarged, palpable, non -tender lymph nodes for an extended period of time. Cervical, axillary, inguinal lymphadenopathy are mostly found. But preauricular, submental, epitrochlear, mediastinal, and retroperitoneal nodes are detected occasionally. Moderate to massive splenomegaly is evident in 85% of patients with ALPS. Minor hepatomegaly is also a common finding. Lymphadenopathy, splenomegaly, hepatomegaly improve with age.

Physical Examination

Skin

Head

  • Lymphadenopathy: >90% of patients present with chronic non-malignant lymphadenopathy. It can be mild to severe, affecting multiple nodal groups. Most commonly presents with massive non-painful hard cervical lymphadenopathy

Abdomen

  • Splenomegaly: >80% of patients present with clinically identifiable splenomegaly. It can be massive.
  • Hepatomegaly: 30-40% of patients have enlarged livers.

References

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