Acrodermatitis chronica atrophicans natural history, complications and prognosis: Difference between revisions
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*[[Skin]] changes first appear as blue and red discoloration with boggy infiltration. These [[skin]] lesions can become [[atrophy|atrophic]] later. | *[[Skin]] changes first appear as blue and red discoloration with boggy infiltration. These [[skin]] lesions can become [[atrophy|atrophic]] later. | ||
*Based on two studies, 55% and 66% of [[patients]] with [[acrodermatitis chronica atrophicans]] have at least one history of [[tick]] [[bite]], while others may never remember such an accident. Since there could be several years between the [[tick]] [[bite]] and development of [[skin]] lesions, absence of [[tick]] [[bite]] in [[patients]]' history is not meaningful alone.<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref> | *Based on two studies, 55% and 66% of [[patients]] with [[acrodermatitis chronica atrophicans]] have at least one history of [[tick]] [[bite]], while others may never remember such an accident. Since there could be several years between the [[tick]] [[bite]] and development of [[skin]] lesions, absence of [[tick]] [[bite]] in [[patients]]' history is not meaningful alone.<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref> | ||
*One fifth of the [[patients]] in a study experienced [[Erythema Migrans|erythema migrans]] 6 months to 8 years before [[acrodermatitis chronica atrophicansis]] development.<ref name="pmid3577484">{{cite journal| author=Asbrink E, Hovmark A, Olsson I| title=Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients. | journal=Zentralbl Bakteriol Mikrobiol Hyg A | year= 1986 | volume= 263 | issue= 1-2 | pages= 253-61 | pmid=3577484 | doi=10.1016/s0176-6724(86)80128-6 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3577484 }} </ref><ref name="pmid6084922">{{cite journal| author=Asbrink E, Hovmark A, Hederstedt B| title=The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer. | journal=Acta Derm Venereol | year= 1984 | volume= 64 | issue= 6 | pages= 506-12 | pmid=6084922 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6084922 }} </ref> | |||
===Complications=== | ===Complications=== | ||
Revision as of 13:13, 2 June 2021
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Anahita Deylamsalehi, M.D.[2] Raviteja Guddeti, M.B.B.S. [3]
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Overview
Natural History, Complications, and Prognosis
Natural History
- The course of acrodermatitis chronica atrophicansis is chronic and could lasts for several years. [1]
- It usually involves extensor surfaces of the acral regions of limbs.[1]
- Skin changes first appear as blue and red discoloration with boggy infiltration. These skin lesions can become atrophic later.
- Based on two studies, 55% and 66% of patients with acrodermatitis chronica atrophicans have at least one history of tick bite, while others may never remember such an accident. Since there could be several years between the tick bite and development of skin lesions, absence of tick bite in patients' history is not meaningful alone.[2]
- One fifth of the patients in a study experienced erythema migrans 6 months to 8 years before acrodermatitis chronica atrophicansis development.[2][3]
Complications
- Common complications of acrodermatitis chronica atrophicansis include:[1]
- Sclerotic skin changes
Prognosis
- Acrodermatitis chronica atrophicansis can lead to extensive atrophy of skin and, in some patients it can cause limitation of upper and lower limb joint mobility.
- The general pognosis is good with proper and rapid treatment in acute inflammatory stage of acrodermatitis chronica atrophicansis.
- The therapeutic outcome is difficult to assess in patients with the chronic atrophic phase because most changes are only partially reversible.
References
- ↑ 1.0 1.1 1.2 Khalili M, Wong RJ (2018). "Underserved Does Not Mean Undeserved: Unfurling the HCV Care in the Safety Net". Dig Dis Sci. 63 (12): 3250–3252. doi:10.1007/s10620-018-5316-9. PMC 6436636. PMID 30311153.
- ↑ 2.0 2.1 Asbrink E, Hovmark A, Olsson I (1986). "Clinical manifestations of acrodermatitis chronica atrophicans in 50 Swedish patients". Zentralbl Bakteriol Mikrobiol Hyg A. 263 (1–2): 253–61. doi:10.1016/s0176-6724(86)80128-6. PMID 3577484.
- ↑ Asbrink E, Hovmark A, Hederstedt B (1984). "The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer". Acta Derm Venereol. 64 (6): 506–12. PMID 6084922.