Acinic cell carcinoma pathophysiology: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
<br /> | |||
== Genetics == | |||
* The development of acinic cell carcinoma is the result of multiple genetic mutations that suggest association of tumor suppression genes such as<ref name="El-NaggarAbdul-Karim1998">{{cite journal|last1=El-Naggar|first1=Adel K|last2=Abdul-Karim|first2=Fadi W|last3=Hurr|first3=Kenneth|last4=Callender|first4=David|last5=Luna|first5=Mario A|last6=Batsakis|first6=John G|title=Genetic Alterations in Acinic Cell Carcinoma of the Parotid Gland Determined by Microsatellite Analysis|journal=Cancer Genetics and Cytogenetics|volume=102|issue=1|year=1998|pages=19–24|issn=01654608|doi=10.1016/S0165-4608(97)00273-2}}</ref><ref name="pmid3178153">{{cite journal| author=Sandros J, Mark J, Happonen RP, Stenman G| title=Specificity of 6q- markers and other recurrent deviations in human malignant salivary gland tumors. | journal=Anticancer Res | year= 1988 | volume= 8 | issue= 4 | pages= 637-43 | pmid=3178153 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3178153 }}</ref>: | |||
** chromosome 5q | |||
** chromosome 6p | |||
** chromosome 17p | |||
<br /> | |||
* Deletions of chromosome 6q | |||
* Loss of Y | |||
* Trisomy 21 | |||
* Molucular syudies suggest that retinoblastoma pathway also can be involved with acinic cell carcinoma.<ref name="LiuZhu2005">{{cite journal|last1=Liu|first1=T|last2=Zhu|first2=E|last3=Wang|first3=L|last4=Okada|first4=T|last5=Yamaguchi|first5=A|last6=Okada|first6=N|title=Abnormal expression of Rb pathway–related proteins in salivary gland acinic cell carcinoma|journal=Human Pathology|volume=36|issue=9|year=2005|pages=962–970|issn=00468177|doi=10.1016/j.humpath.2005.06.014}}</ref> | |||
<br /> | |||
== Associated Conditions == | |||
== Gross Pathology == | |||
* On gross pathology, acinic cell carcinoma usually presents as a solitary, encapsulated, soft tumor of gray-whit appearance. | |||
* In case of recurrent lesions, the tumor is often lobulated without capsule with necrosis area. | |||
[[File:PMC3981376 cp-2011-3-e58-g002.png|center|400 ppx|thumbnail|Patien with acinic cell carcinoma<ref name="SherwaniAkhtar2011">{{cite journal|last1=Sherwani|first1=Rana|last2=Akhtar|first2=Kafil|last3=Ahmad|first3=Murad|last4=Hasan|first4=Abrar|title=Cytologic diagnosis of acinic cell carcinoma of minor salivary gland: a distinct rarely described entity|journal=Clinics and Practice|volume=1|issue=3|year=2011|pages=58|issn=2039-7283|doi=10.4081/cp.2011.e58}}</ref>]] | |||
== Microscopic Pathology == | |||
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name]. | |||
==References== | ==References== |
Revision as of 13:46, 5 September 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ramyar Ghandriz MD[2]
Overview
Pathophysiology
Genetics
- The development of acinic cell carcinoma is the result of multiple genetic mutations that suggest association of tumor suppression genes such as[1][2]:
- chromosome 5q
- chromosome 6p
- chromosome 17p
- Deletions of chromosome 6q
- Loss of Y
- Trisomy 21
- Molucular syudies suggest that retinoblastoma pathway also can be involved with acinic cell carcinoma.[3]
Associated Conditions
Gross Pathology
- On gross pathology, acinic cell carcinoma usually presents as a solitary, encapsulated, soft tumor of gray-whit appearance.
- In case of recurrent lesions, the tumor is often lobulated without capsule with necrosis area.
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ El-Naggar, Adel K; Abdul-Karim, Fadi W; Hurr, Kenneth; Callender, David; Luna, Mario A; Batsakis, John G (1998). "Genetic Alterations in Acinic Cell Carcinoma of the Parotid Gland Determined by Microsatellite Analysis". Cancer Genetics and Cytogenetics. 102 (1): 19–24. doi:10.1016/S0165-4608(97)00273-2. ISSN 0165-4608.
- ↑ Sandros J, Mark J, Happonen RP, Stenman G (1988). "Specificity of 6q- markers and other recurrent deviations in human malignant salivary gland tumors". Anticancer Res. 8 (4): 637–43. PMID 3178153.
- ↑ Liu, T; Zhu, E; Wang, L; Okada, T; Yamaguchi, A; Okada, N (2005). "Abnormal expression of Rb pathway–related proteins in salivary gland acinic cell carcinoma". Human Pathology. 36 (9): 962–970. doi:10.1016/j.humpath.2005.06.014. ISSN 0046-8177.
- ↑ Sherwani, Rana; Akhtar, Kafil; Ahmad, Murad; Hasan, Abrar (2011). "Cytologic diagnosis of acinic cell carcinoma of minor salivary gland: a distinct rarely described entity". Clinics and Practice. 1 (3): 58. doi:10.4081/cp.2011.e58. ISSN 2039-7283.