Ovarian cancer laboratory findings: Difference between revisions
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==Overview== | |||
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Revision as of 20:05, 12 July 2019
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.
Ovarian cancer Microchapters |
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Overview
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- Patients with ovarian cancer can present acutely or sub-acutely
- If there is clinical suspicion of malignancy, the evaluation includes laboratory work, imaging and surgical exploration for the definite diagnosis
- Routine lab work
- CBC
- CBP
- Serum biomarkers of epithelial ovarian cancer (EOC):
- CA 125
- Considered the best for ovarian cancer detection, therapeutic monitoring, and detection of the tumor recurrence
- Postmenopausal woman: should be measured
- Premenopausal woman: should be measured only if US shows highly suspicious malignant mass
- HE4
- CA125 and HE4 are used together to increase the sensitivity and specificity of ovarian cancer detection
- Risk of Ovarian Malignancy Algorithm (ROMA) is used to decide if the patient has a high risk or low-risk malignant disease based on:
- CA125 and HE4 levels
- Menopausal status of the woman
- OVA1
- CA 125
- Serum biomarkers of the germ cell and sex cord-stromal ovarian cancer:
- AFP: alpha-fetoprotein
- hCG: human chorionic gonadotropin
- LDH: lactate dehydrogenase
- E2: estradiol
- Inhibin
- Testost: testosterone
- Andro: androstenedione
- DHEA: dehydroepiandrostenedione
- AMH: anti-Müllerian hormone