Ovarian cancer laboratory findings: Difference between revisions

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{{CMG}}; {{AE}} {{Hudakarman}}
{{Ovarian cancer}}
{{Ovarian cancer}}
==Overview==


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Revision as of 20:05, 12 July 2019


Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Huda A. Karman, M.D.

Ovarian cancer Microchapters

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Patient Information

Overview

Historical Perspective

Classifications

Pathophysiology

Causes of Ovarian cancer

Differentiating Ovarian cancer from other Diseases

Epidemiology & Demographics

Risk Factors

Screening

Natural History, Complications & Prognosis

Diagnosis

History & Symptoms

Physical Examination

Staging

Laboratory Findings

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Case #1

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Risk calculators and risk factors for Ovarian cancer laboratory findings

Overview

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  • Patients with ovarian cancer can present acutely or sub-acutely
  • If there is clinical suspicion of malignancy, the evaluation includes laboratory work, imaging and surgical exploration for the definite diagnosis
  • Routine lab work
    • CBC
    • CBP
  • Serum biomarkers of epithelial ovarian cancer (EOC):
    • CA 125
      • Considered the best for ovarian cancer detection, therapeutic monitoring, and detection of the tumor recurrence
      • Postmenopausal woman: should be measured
      • Premenopausal woman: should be measured only if US shows highly suspicious malignant mass
    • HE4
      • CA125 and HE4 are used together to increase the sensitivity and specificity of ovarian cancer detection
      • Risk of Ovarian Malignancy Algorithm (ROMA) is used to decide if the patient has a high risk or low-risk malignant disease based on:
        • CA125 and HE4 levels
        • Menopausal status of the woman
    • OVA1
  • Serum biomarkers of the germ cell and sex cord-stromal ovarian cancer:
    • AFP: alpha-fetoprotein
    • hCG: human chorionic gonadotropin
    • LDH: lactate dehydrogenase
    • E2: estradiol
    • Inhibin
    • Testost: testosterone
    • Andro: androstenedione
    • DHEA: dehydroepiandrostenedione
    • AMH: anti-Müllerian hormone


References

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