T-cell prolymphocytic leukemia laboratory findings: Difference between revisions
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{{CMG}}; {{AE}}{{Qurrat}}, {{MV}} | {{CMG}}; {{AE}}{{Qurrat}}, {{MV}} | ||
==Overview== | ==Overview== | ||
==Laboratory Findings== | === Laboratory Findings === | ||
* High lymphocyte count (> 100 x | *Laboratory findings consistent with the diagnosis of T-cell prolymphocytic leukemia, include:<ref name="pmid23382603">{{cite journal |vauthors=Graham RL, Cooper B, Krause JR |title=T-cell prolymphocytic leukemia |journal=Proc (Bayl Univ Med Cent) |volume=26 |issue=1 |pages=19–21 |year=2013 |pmid=23382603 |pmc=3523759 |doi= |url=}}</ref> | ||
* [[HTLV | :*High [[lymphocyte]] count (> 100 x 109/L) | ||
:*[[Anemia]] | |||
:*[[Thrombocytopenia]] | |||
:*Negative [[Human T-lymphotropic virus|human T lymphotropic virus]] ([[Human T-lymphotropic virus|HTLV]]) serology | |||
:*Peripheral Blood Smear demonstrated predominance of [[lymphocytes]]: | |||
:**Typical variant: | |||
:*** Medium-sized [[lymphocytes]] | |||
:*** Condensed chromatin and a visible nucleolus | |||
:*** Round nucleus | |||
:*** Slightly basophilic cytoplasm | |||
:*** Cytoplasmic protrusion | |||
:**Small cell variant | |||
:*** Small tumor cells with condensed chromatin | |||
:*** Small nucleolus visible by electron microscopy | |||
:**Cerebriform (Sézary cell-like) variant | |||
:*** Irregular nuclear outline | |||
:*** Similar to cerebriform nucleus of Sézary cells seen in mycosis fungoides | |||
==References== | ==References== | ||
Revision as of 16:59, 26 March 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Maria Fernanda Villarreal, M.D. [3]
Overview
Laboratory Findings
- Laboratory findings consistent with the diagnosis of T-cell prolymphocytic leukemia, include:[1]
- High lymphocyte count (> 100 x 109/L)
- Anemia
- Thrombocytopenia
- Negative human T lymphotropic virus (HTLV) serology
- Peripheral Blood Smear demonstrated predominance of lymphocytes:
- Typical variant:
- Medium-sized lymphocytes
- Condensed chromatin and a visible nucleolus
- Round nucleus
- Slightly basophilic cytoplasm
- Cytoplasmic protrusion
- Small cell variant
- Small tumor cells with condensed chromatin
- Small nucleolus visible by electron microscopy
- Cerebriform (Sézary cell-like) variant
- Irregular nuclear outline
- Similar to cerebriform nucleus of Sézary cells seen in mycosis fungoides
- Typical variant: