Sandbox:Hannan: Difference between revisions

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* MDS, unclassifiable
* MDS, unclassifiable
* Provisional entity: Refractory cytopenia of childhood
* Provisional entity: Refractory cytopenia of childhood
* Myeloid neoplasms with germ line predisposition
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|Acute myeloid leukemia (AML) and related neoplasms
* AML with recurrent genetic abnormalities
# AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1
# AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11
# APL with PML-RARA
# AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A
# AML with t(6;9)(p23;q34.1);DEK-NUP214
# AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM
# AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1
# Provisional entity: AML with BCR-ABL1
# AML with mutated NPM1
# AML with biallelic mutations of CEBPA
# Provisional entity: AML with mutated RUNX1
AML with myelodysplasia-related changes
Therapy-related myeloid neoplasms
AML, NOS
AML with minimal differentiation
AML without maturation
AML with maturation
Acute myelomonocytic leukemia
Acute monoblastic/monocytic leukemia
Pure erythroid leukemia
Acute megakaryoblastic leukemia
Acute basophilic leukemia
Acute panmyelosis with myelofibrosis
Myeloid sarcoma
Myeloid proliferations related to Down syndrome
Transient abnormal myelopoiesis (TAM)
Myeloid leukemia associated with Down syndrome
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Revision as of 12:30, 15 January 2019

Other myeloid neoplasm and acute leukemia
Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of

PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2

  • Myeloid/lymphoid neoplasms with PDGFRA rearrangement
  • Myeloid/lymphoid neoplasms with PDGFRB rearrangement
  • Myeloid/lymphoid neoplasms with FGFR1 rearrangement
  • Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK
Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)
  • Chronic myelomonocytic leukemia (CMML)
  • Atypical chronic myeloid leukemia (aCML), BCR-ABL1-
  • Juvenile myelomonocytic leukemia (JMML)
  • MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
  • MDS/MPN, unclassifiable
Myelodysplastic syndromes (MDS)
  • MDS with single lineage dysplasia
  • MDS with ring sideroblasts (MDS-RS)
  • MDS-RS and single lineage dysplasia
  • MDS-RS and multilineage dysplasia
  • MDS with multilineage dysplasia
  • MDS with excess blasts
  • MDS with isolated del(5q)
  • MDS, unclassifiable
  • Provisional entity: Refractory cytopenia of childhood
  • Myeloid neoplasms with germ line predisposition
Acute myeloid leukemia (AML) and related neoplasms
  • AML with recurrent genetic abnormalities
  1. AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1
  2. AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11
  3. APL with PML-RARA
  4. AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A
  5. AML with t(6;9)(p23;q34.1);DEK-NUP214
  6. AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2);GATA2, MECOM
  7. AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1
  8. Provisional entity: AML with BCR-ABL1
  9. AML with mutated NPM1
  10. AML with biallelic mutations of CEBPA
  11. Provisional entity: AML with mutated RUNX1

AML with myelodysplasia-related changes

Therapy-related myeloid neoplasms

AML, NOS

AML with minimal differentiation

AML without maturation

AML with maturation

Acute myelomonocytic leukemia

Acute monoblastic/monocytic leukemia

Pure erythroid leukemia

Acute megakaryoblastic leukemia

Acute basophilic leukemia

Acute panmyelosis with myelofibrosis

Myeloid sarcoma

Myeloid proliferations related to Down syndrome

Transient abnormal myelopoiesis (TAM)

Myeloid leukemia associated with Down syndrome

Myeloproliferative neoplasms (MPN) Clinical manifestations Diagnosis Other Features
Symptoms Physical examination Laboratory Findings Bone Marrow Biopsy Gold Standard Others
Chronic myeloid leukemia

(CML), BCR-ABL1+

Chronic neutrophilic leukemia (CNL)
Polycythemia vera (PV)
Primary myelofibrosis (PMF)
  • prefibrotic/early stage
  • overt fibrotic stage
Essential thrombocythemia (ET)
Chronic eosinophilic leukemia, not otherwise specified (NOS)
MPN, unclassifiable
Mastocytosis