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{{Infobox_gene}}
{{Infobox_gene}}
'''E3 ubiquitin-protein ligase Praja1''' is an [[enzyme]] that in humans is encoded by the ''PJA1'' [[gene]].<ref name="pmid12036302">{{cite journal |vauthors=Yu P, Chen Y, Tagle DA, Cai T | title = PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain | journal = Genomics | volume = 79 | issue = 6 | pages = 869–74 |date=May 2002 | pmid = 12036302 | pmc =  | doi = 10.1006/geno.2002.6770 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PJA1 praja 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64219| accessdate = }}</ref>
'''E3 ubiquitin-protein ligase Praja1''' is an [[enzyme]] that in humans is encoded by the ''PJA1'' [[gene]].<ref name="pmid12036302">{{cite journal |vauthors=Yu P, Chen Y, Tagle DA, Cai T | title = PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain | journal = Genomics | volume = 79 | issue = 6 | pages = 869–74 |date=May 2002 | pmid = 12036302 | pmc =  | doi = 10.1006/geno.2002.6770 | url = https://zenodo.org/record/1229812 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PJA1 praja 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64219| accessdate = }}</ref>


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==Interactions==
==Interactions==
PJA1 has been shown to [[Protein-protein interaction|interact]] with [[UBE2D2]]<ref name=pmid12036302 /> and [[MAGED1]].<ref name=pmid11959851>{{cite journal |last=Sasaki |first=Aya |authorlink= |author2=Masuda Yoshiko |author3=Iwai Kazuhiro |author4=Ikeda Kyoji |author5=Watanabe Ken  |date=Jun 2002 |title=A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 |journal=J. Biol. Chem. |volume=277 |issue=25 |pages=22541–6 |publisher= |location = United States| issn = 0021-9258| pmid = 11959851 |doi = 10.1074/jbc.M109728200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
PJA1 has been shown to [[Protein-protein interaction|interact]] with [[UBE2D2]]<ref name=pmid12036302 /> and [[MAGED1]].<ref name=pmid11959851>{{cite journal |last=Sasaki |first=Aya |authorlink= |author2=Masuda Yoshiko |author3=Iwai Kazuhiro |author4=Ikeda Kyoji |author5=Watanabe Ken  |date=Jun 2002 |title=A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 |journal=J. Biol. Chem. |volume=277 |issue=25 |pages=22541–6 | issn = 0021-9258| pmid = 11959851 |doi = 10.1074/jbc.M109728200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
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*{{cite journal  | author=Fang S |title=Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8945–51 |year= 2000 |pmid= 10722742 |doi=10.1074/jbc.275.12.8945  |name-list-format=vanc| author2=Jensen JP  | author3=Ludwig RL  | display-authors=3  | last4=Vousden  | first4=KH  | last5=Weissman  | first5=AM  }}
*{{cite journal  | author=Fang S |title=Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 |journal=J. Biol. Chem. |volume=275 |issue= 12 |pages= 8945–51 |year= 2000 |pmid= 10722742 |doi=10.1074/jbc.275.12.8945  |name-list-format=vanc| author2=Jensen JP  | author3=Ludwig RL  | display-authors=3  | last4=Vousden  | first4=KH  | last5=Weissman  | first5=AM  }}
*{{cite journal  | author=Sasaki A |title=A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22541–6 |year= 2002 |pmid= 11959851 |doi= 10.1074/jbc.M109728200  |name-list-format=vanc| author2=Masuda Y  | author3=Iwai K  | display-authors=3  | last4=Ikeda  | first4=K  | last5=Watanabe  | first5=K }}
*{{cite journal  | author=Sasaki A |title=A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1 |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22541–6 |year= 2002 |pmid= 11959851 |doi= 10.1074/jbc.M109728200  |name-list-format=vanc| author2=Masuda Y  | author3=Iwai K  | display-authors=3  | last4=Ikeda  | first4=K  | last5=Watanabe  | first5=K }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440  | pmc=2665286  |name-list-format=vanc| author2=Grafham DV  | author3=Coffey AJ  | display-authors=3  | last4=Scherer  | first4=Steven  | last5=McLay  | first5=Kirsten  | last6=Muzny  | first6=Donna  | last7=Platzer  | first7=Matthias  | last8=Howell  | first8=Gareth R.  | last9=Burrows  | first9=Christine }}
*{{cite journal  | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440  | pmc=2665286  |name-list-format=vanc| author2=Grafham DV  | author3=Coffey AJ  | display-authors=3  | last4=Scherer  | first4=Steven  | last5=McLay  | first5=Kirsten  | last6=Muzny  | first6=Donna  | last7=Platzer  | first7=Matthias  | last8=Howell  | first8=Gareth R.  | last9=Burrows  | first9=Christine |bibcode=2005Natur.434..325R}}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
*{{cite journal  | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129  |name-list-format=vanc| author2=Wakamatsu A  | author3=Suzuki Y  | display-authors=3  | last4=Ota  | first4=T  | last5=Nishikawa  | first5=T  | last6=Yamashita  | first6=R  | last7=Yamamoto  | first7=J  | last8=Sekine  | first8=M  | last9=Tsuritani  | first9=K }}
}}
}}

Latest revision as of 22:42, 5 September 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the PJA1 gene.[1][2]


Interactions

PJA1 has been shown to interact with UBE2D2[1] and MAGED1.[3]

References

  1. 1.0 1.1 Yu P, Chen Y, Tagle DA, Cai T (May 2002). "PJA1, encoding a RING-H2 finger ubiquitin ligase, is a novel human X chromosome gene abundantly expressed in brain". Genomics. 79 (6): 869–74. doi:10.1006/geno.2002.6770. PMID 12036302.
  2. "Entrez Gene: PJA1 praja 1".
  3. Sasaki, Aya; Masuda Yoshiko; Iwai Kazuhiro; Ikeda Kyoji; Watanabe Ken (Jun 2002). "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1". J. Biol. Chem. 277 (25): 22541–6. doi:10.1074/jbc.M109728200. ISSN 0021-9258. PMID 11959851.

Further reading