RABGEF1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Rab5 GDP/GTP exchange factor''' is a [[protein]] that in humans is encoded by the ''RABGEF1'' [[gene]].<ref name="pmid12505986">{{cite journal | vauthors = Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS | title = Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex | journal = EMBO J | volume = 22 | issue = 1 | pages = 78–88 |date=Dec 2002 | pmid = 12505986 | pmc = 140067 | doi = 10.1093/emboj/cdg015 }}</ref><ref name="pmid11098082">{{cite journal | vauthors = Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Muller O | title = Seven genes that are differentially transcribed in colorectal tumor cell lines | journal = Cancer Lett | volume = 160 | issue = 1 | pages = 37–43 |date=Dec 2000 | pmid = 11098082 | pmc =  | doi =10.1016/S0304-3835(00)00553-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27342| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RABGEF1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1txu.
| PDB = {{PDB2|1txu}}, {{PDB2|2c7m}}, {{PDB2|2c7n}}, {{PDB2|2fid}}, {{PDB2|2fif}}, {{PDB2|2ot3}}
| Name = RAB guanine nucleotide exchange factor (GEF) 1
| HGNCid = 17676
| Symbol = RABGEF1
| AltSymbols =; FLJ32302; RABEX5; rabex-5
| OMIM = 609700
| ECnumber =
| Homologene = 8720
| MGIid = 1929459
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component =  
| Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27342
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_055319
    | Hs_RefseqmRNA = NM_014504
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 56715
    | Mm_Ensembl = ENSMUSG00000025340
    | Mm_RefseqmRNA = NM_019983
    | Mm_RefseqProtein = NP_064367
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 130471883
    | Mm_GenLoc_end = 130499040
    | Mm_Uniprot = Q9JM13
  }}
}}
'''RAB guanine nucleotide exchange factor (GEF) 1''', also known as '''RABGEF1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27342| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27342| accessdate = }}</ref>
| summary_text = RABGEF1 forms a complex with [[rabaptin-5]] (RABPT5; MIM 603616) that is required for [[endocytic]] [[membrane]] fusion, and it serves as a specific [[guanine nucleotide exchange factor]] for RAB5([[RAB5A]]; MIM 179512) (Horiuchi et al., 1997) [supplied by OMIM]<ref name="entrez" />
}}
}}.


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Horiuchi H, Lippé R, McBride HM, ''et al.'' |title=A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. |journal=Cell |volume=90 |issue= 6 |pages= 1149-59 |year= 1997 |pmid= 9323142 |doi=  }}
*{{cite journal   |vauthors=Horiuchi H, Lippé R, McBride HM, etal |title=A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. |journal=Cell |volume=90 |issue= 6 |pages= 1149–59 |year= 1997 |pmid= 9323142 |doi=10.1016/S0092-8674(00)80380-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Nimmrich I, Erdmann S, Melchers U, ''et al.'' |title=Seven genes that are differentially transcribed in colorectal tumor cell lines. |journal=Cancer Lett. |volume=160 |issue= 1 |pages= 37-43 |year= 2000 |pmid= 11098082 |doi= }}
*{{cite journal   |vauthors=Lippé R, Miaczynska M, Rybin V, etal |title=Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. |journal=Mol. Biol. Cell |volume=12 |issue= 7 |pages= 2219–28 |year= 2001 |pmid= 11452015 |doi= 10.1091/mbc.12.7.2219| pmc=55678 }}
*{{cite journal | author=Lippé R, Miaczynska M, Rybin V, ''et al.'' |title=Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. |journal=Mol. Biol. Cell |volume=12 |issue= 7 |pages= 2219-28 |year= 2001 |pmid= 11452015 |doi=  }}
*{{cite journal  | vauthors=de Renzis S, Sönnichsen B, Zerial M |title=Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 124–33 |year= 2002 |pmid= 11788822 |doi= 10.1038/ncb744 }}
*{{cite journal  | author=de Renzis S, Sönnichsen B, Zerial M |title=Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 124-33 |year= 2002 |pmid= 11788822 |doi= 10.1038/ncb744 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Mattera R, Arighi CN, Lodge R, ''et al.'' |title=Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex. |journal=EMBO J. |volume=22 |issue= 1 |pages= 78-88 |year= 2003 |pmid= 12505986 |doi= 10.1093/emboj/cdg015 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Delprato A, Merithew E, Lambright DG |title=Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. |journal=Cell |volume=118 |issue= 5 |pages= 607–17 |year= 2004 |pmid= 15339665 |doi= 10.1016/j.cell.2004.08.009 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Delprato A, Merithew E, Lambright DG |title=Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. |journal=Cell |volume=118 |issue= 5 |pages= 607-17 |year= 2004 |pmid= 15339665 |doi= 10.1016/j.cell.2004.08.009 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Penengo L, Mapelli M, Murachelli AG, etal |title=Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. |journal=Cell |volume=124 |issue= 6 |pages= 1183–95 |year= 2006 |pmid= 16499958 |doi= 10.1016/j.cell.2006.02.020 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Kalesnikoff J, Rios EJ, Chen CC, etal |title=Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells. |journal=Blood |volume=109 |issue= 12 |pages= 5308–17 |year= 2007 |pmid= 17341663 |doi= 10.1182/blood-2007-01-067363 | pmc=1890836 }}
*{{cite journal | author=Penengo L, Mapelli M, Murachelli AG, ''et al.'' |title=Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. |journal=Cell |volume=124 |issue= 6 |pages= 1183-95 |year= 2006 |pmid= 16499958 |doi= 10.1016/j.cell.2006.02.020 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal | author=Kalesnikoff J, Rios EJ, Chen CC, ''et al.'' |title=Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells. |journal=Blood |volume=109 |issue= 12 |pages= 5308-17 |year= 2007 |pmid= 17341663 |doi= 10.1182/blood-2007-01-067363 }}
*{{cite journal  | vauthors=Delprato A, Lambright DG |title=Structural basis for Rab GTPase activation by VPS9 domain exchange factors. |journal=Nat. Struct. Mol. Biol. |volume=14 |issue= 5 |pages= 406–12 |year= 2007 |pmid= 17450153 |doi= 10.1038/nsmb1232 | pmc=2254184 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal  | author=Delprato A, Lambright DG |title=Structural basis for Rab GTPase activation by VPS9 domain exchange factors. |journal=Nat. Struct. Mol. Biol. |volume=14 |issue= 5 |pages= 406-12 |year= 2007 |pmid= 17450153 |doi= 10.1038/nsmb1232 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=27342}}
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Latest revision as of 06:53, 21 July 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene.[1][2][3]

RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5(RAB5A; MIM 179512) (Horiuchi et al., 1997) [supplied by OMIM][3].

References

  1. ↑ Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS (Dec 2002). "Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex". EMBO J. 22 (1): 78–88. doi:10.1093/emboj/cdg015. PMC 140067. PMID 12505986.
  2. ↑ Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Muller O (Dec 2000). "Seven genes that are differentially transcribed in colorectal tumor cell lines". Cancer Lett. 160 (1): 37–43. doi:10.1016/S0304-3835(00)00553-X. PMID 11098082.
  3. ↑ 3.0 3.1 "Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1".

Further reading



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