NFKBIZ: Difference between revisions
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'''NF-kappa-B inhibitor zeta''' is a [[protein]] that in humans is encoded by the ''NFKBIZ'' [[gene]].<ref name="pmid12565889">{{cite journal | vauthors = Eto A, Muta T, Yamazaki S, Takeshige K | title = Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta | journal = Biochem Biophys Res Commun | volume = 301 | issue = 2 | pages = 495–501 |date=Feb 2003 | pmid = 12565889 | pmc = | doi =10.1016/S0006-291X(02)03082-6 }}</ref><ref name="pmid16513645">{{cite journal | vauthors = Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Janicke RU, Schulze-Osthoff K | title = A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding | journal = J Biol Chem | volume = 281 | issue = 18 | pages = 12645–54 |date=May 2006 | pmid = 16513645 | pmc = | doi = 10.1074/jbc.M511956200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64332| accessdate = }}</ref> | '''NF-kappa-B inhibitor zeta''' is a [[protein]] that in humans is encoded by the ''NFKBIZ'' [[gene]].<ref name="pmid12565889">{{cite journal | vauthors = Eto A, Muta T, Yamazaki S, Takeshige K | title = Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta | journal = Biochem Biophys Res Commun | volume = 301 | issue = 2 | pages = 495–501 |date=Feb 2003 | pmid = 12565889 | pmc = | doi =10.1016/S0006-291X(02)03082-6 }}</ref><ref name="pmid16513645">{{cite journal | vauthors = Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Janicke RU, Schulze-Osthoff K | title = A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding | journal = J Biol Chem | volume = 281 | issue = 18 | pages = 12645–54 |date=May 2006 | pmid = 16513645 | pmc = | doi = 10.1074/jbc.M511956200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64332| accessdate = }}</ref> | ||
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{{PBB_Summary | {{PBB_Summary | ||
| section_title = | | section_title = | ||
| summary_text = This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" /> | | summary_text = This gene is a member of the ankyrin-repeat family and is induced by [[lipopolysaccharide]] (LPS). The C-terminal portion of the encoded product which contains the [[ankyrin]] repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in [[inflammation|inflammatory]] responses to LPS by their interaction with [[NF-B]] proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different [[isoforms]] have been found for this gene.<ref name="entrez" /> | ||
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*{{cite journal | vauthors=Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M |title=MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. |journal=FEBS Lett. |volume=485 |issue= 1 |pages= 53–6 |year= 2000 |pmid= 11086164 |doi= 10.1016/S0014-5793(00)02185-2 }} | *{{cite journal | vauthors=Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M |title=MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production. |journal=FEBS Lett. |volume=485 |issue= 1 |pages= 53–6 |year= 2000 |pmid= 11086164 |doi= 10.1016/S0014-5793(00)02185-2 }} | ||
*{{cite journal | vauthors=Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B |title=Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene. |journal=Immunogenetics | *{{cite journal | vauthors=Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B |title=Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene. |journal=Immunogenetics |volume=53 |issue= 8 |pages= 649–55 |year= 2001 |pmid= 11797098 |doi=10.1007/s00251-001-0376-x }} | ||
*{{cite journal | vauthors=Haruta H, Kato A, Todokoro K |title=Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12485–8 |year= 2001 |pmid= 11278262 |doi= 10.1074/jbc.C100075200 }} | *{{cite journal | vauthors=Haruta H, Kato A, Todokoro K |title=Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12485–8 |year= 2001 |pmid= 11278262 |doi= 10.1074/jbc.C100075200 }} | ||
*{{cite journal | vauthors=Yamazaki S, Muta T, Takeshige K |title=A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27657–62 |year= 2001 |pmid= 11356851 |doi= 10.1074/jbc.M103426200 }} | *{{cite journal | vauthors=Yamazaki S, Muta T, Takeshige K |title=A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei. |journal=J. Biol. Chem. |volume=276 |issue= 29 |pages= 27657–62 |year= 2001 |pmid= 11356851 |doi= 10.1074/jbc.M103426200 }} | ||
Latest revision as of 19:39, 13 March 2018
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NF-kappa-B inhibitor zeta is a protein that in humans is encoded by the NFKBIZ gene.[1][2][3]
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.[3]
References
- ↑ Eto A, Muta T, Yamazaki S, Takeshige K (Feb 2003). "Essential roles for NF-kappa B and a Toll/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta". Biochem Biophys Res Commun. 301 (2): 495–501. doi:10.1016/S0006-291X(02)03082-6. PMID 12565889.
- ↑ Totzke G, Essmann F, Pohlmann S, Lindenblatt C, Janicke RU, Schulze-Osthoff K (May 2006). "A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding". J Biol Chem. 281 (18): 12645–54. doi:10.1074/jbc.M511956200. PMID 16513645.
- ↑ 3.0 3.1 "Entrez Gene: NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta".
Further reading
- Kitamura H, Kanehira K, Okita K, Morimatsu M, Saito M (2000). "MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production". FEBS Lett. 485 (1): 53–6. doi:10.1016/S0014-5793(00)02185-2. PMID 11086164.
- Shiina T, Morimatsu M, Kitamura H, Ito T, Kidou S, Matsubara K, Matsuda Y, Saito M, Syuto B (2001). "Genomic organization, chromosomal localization, and promoter analysis of the mouse Mail gene". Immunogenetics. 53 (8): 649–55. doi:10.1007/s00251-001-0376-x. PMID 11797098.
- Haruta H, Kato A, Todokoro K (2001). "Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs". J. Biol. Chem. 276 (16): 12485–8. doi:10.1074/jbc.C100075200. PMID 11278262.
- Yamazaki S, Muta T, Takeshige K (2001). "A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei". J. Biol. Chem. 276 (29): 27657–62. doi:10.1074/jbc.M103426200. PMID 11356851.
- Kitamura H, Kanehira K, Shiina T, Morimatsu M, Jung BD, Akashi S, Saito M (2002). "Bacterial lipopolysaccharide induces mRNA expression of an IkappaB MAIL through toll-like receptor 4". J. Vet. Med. Sci. 64 (5): 419–22. doi:10.1292/jvms.64.419. PMID 12069074.
- Kitamura H, Matsushita Y, Iwanaga T, Mori K, Kanehira K, Fujikura D, Morimatsu M, Saito M (2003). "Bacterial lipopolysaccharide-induced expression of the IkappaB protein MAIL in B-lymphocytes and macrophages". Arch. Histol. Cytol. 66 (1): 53–62. doi:10.1679/aohc.66.53. PMID 12703554.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Shiina T, Konno A, Oonuma T, Kitamura H, Imaoka K, Takeda N, Todokoro K, Morimatsu M (2004). "Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease". J. Biol. Chem. 279 (53): 55493–8. doi:10.1074/jbc.M409770200. PMID 15491998.
- Ito T, Morimatsu M, Oonuma T, Shiina T, Kitamura H, Syuto B (2004). "Transcriptional regulation of the MAIL gene in LPS-stimulated RAW264 mouse macrophages". Gene. 342 (1): 137–43. doi:10.1016/j.gene.2004.07.032. PMID 15527973.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Yamamoto M, Yamazaki S, Uematsu S, et al. (2004). "Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta". Nature. 430 (6996): 218–22. doi:10.1038/nature02738. PMID 15241416.
- Yamaji D, Kitamura H, Kimura K, Matsushita Y, Okada H, Shiina T, Morimatsu M, Saito M (2004). "Cloning of bovine MAIL and its mRNA expression in white blood cells of Holstein cows". Vet. Immunol. Immunopathol. 98 (3–4): 175–84. doi:10.1016/j.vetimm.2003.12.004. PMID 15010226.
- Yamazaki S, Muta T, Matsuo S, Takeshige K (2005). "Stimulus-specific induction of a novel nuclear factor-kappaB regulator, IkappaB-zeta, via Toll/Interleukin-1 receptor is mediated by mRNA stabilization". J. Biol. Chem. 280 (2): 1678–87. doi:10.1074/jbc.M409983200. PMID 15522867.
- Motoyama M, Yamazaki S, Eto-Kimura A, et al. (2005). "Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein". J. Biol. Chem. 280 (9): 7444–51. doi:10.1074/jbc.M412738200. PMID 15618216.
- Cowland JB, Muta T, Borregaard N (2006). "IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta". J. Immunol. 176 (9): 5559–66. doi:10.4049/jimmunol.176.9.5559. PMID 16622025.
- Oonuma T, Morimatsu M, Ochiai K, Iwanaga T, Hashizume K (2007). "Role of NF-kappaB in constitutive expression of MAIL in epidermal keratinocytes". J Vet Med Sci. 69 (3): 279–84. doi:10.1292/jvms.69.279. PMID 17409644.
- Matsuo S, Yamazaki S, Takeshige K, Muta T (2007). "Crucial roles of binding sites for NF-kappaB and C/EBPs in IkappaB-zeta-mediated transcriptional activation". Biochem. J. 405 (3): 605–15. doi:10.1042/BJ20061797. PMC 2267307. PMID 17447895.
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