STEAP3: Difference between revisions

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{{Infobox_gene}}
{{Infobox_gene}}
'''Metalloreductase STEAP3''' is an [[enzyme]] that in humans is encoded by the ''STEAP3'' [[gene]].<ref name="pmid12606722">{{cite journal | vauthors = Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A | title = The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 5 | pages = 2284–9 | date = Mar 2003 | pmid = 12606722 | pmc = 151332 | doi = 10.1073/pnas.0530298100 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STEAP3 STEAP family member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55240| accessdate = }}</ref>
'''Metalloreductase STEAP3''' is an [[enzyme]] that in humans is encoded by the ''STEAP3'' [[gene]].<ref name="pmid12606722">{{cite journal | vauthors = Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A | title = The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 5 | pages = 2284–9 | date = March 2003 | pmid = 12606722 | pmc = 151332 | doi = 10.1073/pnas.0530298100 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STEAP3 STEAP family member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=55240| access-date = }}</ref>


STEAP3 is a metalloreductase, capable of coverting iron from an insoluble [[ferric]] (Fe<sup>3+</sup>) to a soluble  [[ferrous]] (Fe<sup>2+</sup>) form.<ref name="pmid16609065">{{cite journal | vauthors = Ohgami RS, Campagna DR, McDonald A, Fleming MD | title = The Steap proteins are metalloreductases | journal = Blood | volume = 108 | issue = 4 | pages = 1388–94 | date = August 2006 | pmid = 16609065 | pmc = 1785011 | doi = 10.1182/blood-2006-02-003681 }}</ref>
STEAP3 is a metalloreductase, capable of coverting iron from an insoluble [[ferric]] (Fe<sup>3+</sup>) to a soluble  [[ferrous]] (Fe<sup>2+</sup>) form.<ref name="pmid16609065">{{cite journal | vauthors = Ohgami RS, Campagna DR, McDonald A, Fleming MD | title = The Steap proteins are metalloreductases | journal = Blood | volume = 108 | issue = 4 | pages = 1388–94 | date = August 2006 | pmid = 16609065 | pmc = 1785011 | doi = 10.1182/blood-2006-02-003681 }}</ref>
STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a [[Rossmann fold|Di-nucleotide binding domain (Rossmann Fold).]] This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: [http://www.rcsb.org/structure/2VNS 2VNS], [http://www.rcsb.org/structure/2VQ3 2VQ3] and [http://www.rcsb.org/structure/2YJZ 2YJZ]).<ref>{{cite journal | vauthors = Sendamarai AK, Ohgami RS, Fleming MD, Lawrence CM | title = Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 105 | issue = 21 | pages = 7410–5 | date = May 2008 | pmid = 18495927 | pmc = 2396704 | doi = 10.1073/pnas.0801318105 | url = http://scholarworks.montana.edu/xmlui/bitstream/1/2243/1/SendamaraiA1209.pdf }}</ref><ref>{{cite journal | vauthors = Gauss GH, Kleven MD, Sendamarai AK, Fleming MD, Lawrence CM | title = The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site | journal = The Journal of Biological Chemistry | volume = 288 | issue = 28 | pages = 20668–82 | date = July 2013 | pmid = 23733181 | pmc = 3711330 | doi = 10.1074/jbc.M113.479154 }}</ref>


== Interactions ==
== Interactions ==
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== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination. | journal = Genome Res. | volume = 10 | issue = 11 | pages = 1788–95 | year = 2001 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = November 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. | journal = Genome Res. | volume = 11 | issue = 3 | pages = 422–35 | year = 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = March 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
* {{cite journal | vauthors = Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F | title = Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer. | journal = J. Biol. Chem. | volume = 277 | issue = 39 | pages = 36689–96 | year = 2002 | pmid = 12095985 | doi = 10.1074/jbc.M202414200 }}
* {{cite journal | vauthors = Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F | title = Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 36689–96 | date = September 2002 | pmid = 12095985 | doi = 10.1074/jbc.M202414200 }}
* {{cite journal | vauthors = Amzallag N, Passer BJ, Allanic D, Segura E, Théry C, Goud B, Amson R, Telerman A | title = TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. | journal = J. Biol. Chem. | volume = 279 | issue = 44 | pages = 46104–12 | year = 2004 | pmid = 15319436 | doi = 10.1074/jbc.M404850200 }}
* {{cite journal | vauthors = Amzallag N, Passer BJ, Allanic D, Segura E, Théry C, Goud B, Amson R, Telerman A | title = TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway | journal = The Journal of Biological Chemistry | volume = 279 | issue = 44 | pages = 46104–12 | date = October 2004 | pmid = 15319436 | doi = 10.1074/jbc.M404850200 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline. | journal = Genome Res. | volume = 14 | issue = 10B | pages = 2136–44 | year = 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A | title = From ORFeome to biology: a functional genomics pipeline | journal = Genome Research | volume = 14 | issue = 10B | pages = 2136–44 | date = October 2004 | pmid = 15489336 | pmc = 528930 | doi = 10.1101/gr.2576704 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006. | journal = Nucleic Acids Res. | volume = 34 | issue = Database issue | pages = D415–8 | year = 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
* {{cite journal | vauthors = Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S | title = The LIFEdb database in 2006 | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D415-8 | date = January 2006 | pmid = 16381901 | pmc = 1347501 | doi = 10.1093/nar/gkj139 }}
{{refend}}
{{refend}}


Latest revision as of 15:44, 4 November 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.[1][2]

STEAP3 is a metalloreductase, capable of coverting iron from an insoluble ferric (Fe3+) to a soluble ferrous (Fe2+) form.[3]

STEAP3 and other STEAP protein, with the exception of STEAP1, are predicted to contain a Di-nucleotide binding domain (Rossmann Fold). This has been shown using X-ray crystallography in the cases of STEAP3 and STEAP4 (PDB: 2VNS, 2VQ3 and 2YJZ).[4][5]

Interactions

STEAP3 has been shown to interact with BNIP3L[1] and PKMYT1.[1]

References

  1. ↑ 1.0 1.1 1.2 Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (March 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.
  2. ↑ "Entrez Gene: STEAP3 STEAP family member 3".
  3. ↑ Ohgami RS, Campagna DR, McDonald A, Fleming MD (August 2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC 1785011. PMID 16609065.
  4. ↑ Sendamarai AK, Ohgami RS, Fleming MD, Lawrence CM (May 2008). "Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle" (PDF). Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7410–5. doi:10.1073/pnas.0801318105. PMC 2396704. PMID 18495927.
  5. ↑ Gauss GH, Kleven MD, Sendamarai AK, Fleming MD, Lawrence CM (July 2013). "The crystal structure of six-transmembrane epithelial antigen of the prostate 4 (Steap4), a ferri/cuprireductase, suggests a novel interdomain flavin-binding site". The Journal of Biological Chemistry. 288 (28): 20668–82. doi:10.1074/jbc.M113.479154. PMC 3711330. PMID 23733181.

Further reading

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