Rhomboid, veinlet-like 2 (drosophila): Difference between revisions

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{{Underlinked|date=September 2014}}
{{Infobox_gene}}
{{Infobox_gene}}
'''Rhomboid, veinlet-like 2 (Drosophila)''' is a [[protein]] that in humans is encoded by the RHBDL2 [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila) | url = https://www.ncbi.nlm.nih.gov/gene/54933 }}</ref>


'''Rhomboid, veinlet-like 2 (Drosophila)''' is a [[protein]] that in humans is encoded by the RHBDL2 [[gene]].
== Function ==
<ref name="entrez">
{{cite web
| title = Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)
| url = https://www.ncbi.nlm.nih.gov/gene/54933
| accessdate = 2014-09-11 <!-- T11:03:43.497757-08:00 -->
}}</ref>


==Function==
The protein encoded by this gene is a member of the [[rhomboid protease|rhomboid]] family of [[integral membrane protein]]s. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both [[prokaryote]]s and [[eukaryote]]s and are thought to function as intramembrane [[serine protease]]s. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including [[ephrin B2]] and [[ephrin B3]].
 
The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3. [provided by RefSeq, Jul 2008]. ##Evidence-Data-START## CDS exon combination :: BC137108.1, AY126343.1 [ECO:0000331] RNAseq introns      :: single sample supports all introns                        ERS025085, ERS025087 [ECO:0000348] ##Evidence-Data-END##


== References ==
== References ==
{{reflist}}
{{reflist}}


== Further reading ==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
*{{Cite journal
* {{cite journal | vauthors = Adrain C, Strisovsky K, Zettl M, Hu L, Lemberg MK, Freeman M | title = Mammalian EGF receptor activation by the rhomboid protease RHBDL2 | journal = EMBO Reports | volume = 12 | issue = 5 | pages = 421–7 | date = May 2011 | pmid = 21494248 | pmc = 3090019 | doi = 10.1038/embor.2011.50 }}
| pmid = 21494248
* {{cite journal | vauthors = Pascall JC, Brown KD | title = Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2 | journal = Biochemical and Biophysical Research Communications | volume = 317 | issue = 1 | pages = 244–52 | date = April 2004 | pmid = 15047175 | doi = 10.1016/j.bbrc.2004.03.039 }}
| pmc = 3090019
* {{cite journal | vauthors = Cheng TL, Wu YT, Lin HY, Hsu FC, Liu SK, Chang BI, Chen WS, Lai CH, Shi GY, Wu HL | title = Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing | journal = The Journal of Investigative Dermatology | volume = 131 | issue = 12 | pages = 2486–94 | date = December 2011 | pmid = 21833011 | doi = 10.1038/jid.2011.230 }}
| year = 2011
* {{cite journal | vauthors = Xu J, Zheng SL, Isaacs SD, Wiley KE, Wiklund F, Sun J, Kader AK, Li G, Purcell LD, Kim ST, Hsu FC, Stattin P, Hugosson J, Adolfsson J, Walsh PC, Trent JM, Duggan D, Carpten J, Grönberg H, Isaacs WB | title = Inherited genetic variant predisposes to aggressive but not indolent prostate cancer | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 107 | issue = 5 | pages = 2136–40 | date = February 2010 | pmid = 20080650 | pmc = 2836698 | doi = 10.1073/pnas.0914061107 }}
| author1 = Adrain
* {{cite journal | vauthors = Urban S, Freeman M | title = Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain | journal = Molecular Cell | volume = 11 | issue = 6 | pages = 1425–34 | date = June 2003 | pmid = 12820957 | doi = 10.1016/s1097-2765(03)00181-3 }}
| first1 = C
* {{cite journal | vauthors = Urban S, Lee JR, Freeman M | title = Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases | journal = Cell | volume = 107 | issue = 2 | pages = 173–82 | date = October 2001 | pmid = 11672525 | doi = 10.1016/s0092-8674(01)00525-6 }}
| title = Mammalian EGF receptor activation by the rhomboid protease RHBDL2
* {{cite journal | vauthors = Lei X, Li YM | title = The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity | journal = Journal of Molecular Biology | volume = 394 | issue = 5 | pages = 815–25 | date = December 2009 | pmid = 19850051 | doi = 10.1016/j.jmb.2009.10.025 }}
| journal = EMBO Reports
| volume = 12
| issue = 5
| pages = 421–7
| last2 = Strisovsky
| first2 = K
| last3 = Zettl
| first3 = M
| last4 = Hu
| first4 = L
| last5 = Lemberg
| first5 = M. K.
| last6 = Freeman
| first6 = M
| doi = 10.1038/embor.2011.50
}}
*{{Cite journal
| pmid = 15047175
| year = 2004
| author1 = Pascall
| first1 = J. C.
| title = Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2
| journal = Biochemical and Biophysical Research Communications
| volume = 317
| issue = 1
| pages = 244–52
| last2 = Brown
| first2 = K. D.
| doi = 10.1016/j.bbrc.2004.03.039
}}
*{{Cite journal
| pmid = 21833011
| year = 2011
| author1 = Cheng
| first1 = T. L.
| title = Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing
| journal = Journal of Investigative Dermatology
| volume = 131
| issue = 12
| pages = 2486–94
| last2 = Wu
| first2 = Y. T.
| last3 = Lin
| first3 = H. Y.
| last4 = Hsu
| first4 = F. C.
| last5 = Liu
| first5 = S. K.
| last6 = Chang
| first6 = B. I.
| last7 = Chen
| first7 = W. S.
| last8 = Lai
| first8 = C. H.
| last9 = Shi
| first9 = G. Y.
| last10 = Wu
| first10 = H. L.
| doi = 10.1038/jid.2011.230
}}
*{{Cite journal
| pmid = 20080650
| pmc = 2836698
| year = 2010
| author1 = Xu
| first1 = J
| title = Inherited genetic variant predisposes to aggressive but not indolent prostate cancer
| journal = Proceedings of the National Academy of Sciences
| volume = 107
| issue = 5
| pages = 2136–40
| last2 = Zheng
| first2 = S. L.
| last3 = Isaacs
| first3 = S. D.
| last4 = Wiley
| first4 = K. E.
| last5 = Wiklund
| first5 = F
| last6 = Sun
| first6 = J
| last7 = Kader
| first7 = A. K.
| last8 = Li
| first8 = G
| last9 = Purcell
| first9 = L. D.
| last10 = Kim
| first10 = S. T.
| last11 = Hsu
| first11 = F. C.
| last12 = Stattin
| first12 = P
| last13 = Hugosson
| first13 = J
| last14 = Adolfsson
| first14 = J
| last15 = Walsh
| first15 = P. C.
| last16 = Trent
| first16 = J. M.
| last17 = Duggan
| first17 = D
| last18 = Carpten
| first18 = J
| last19 = Grönberg
| first19 = H
| last20 = Isaacs
| first20 = W. B.
| doi = 10.1073/pnas.0914061107
}}
*{{Cite journal
| pmid = 12820957
| year = 2003
| author1 = Urban
| first1 = S
| title = Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain
| journal = Molecular Cell
| volume = 11
| issue = 6
| pages = 1425–34
| last2 = Freeman
| first2 = M
| doi=10.1016/s1097-2765(03)00181-3
}}
*{{Cite journal
| pmid = 11672525
| year = 2001
| author1 = Urban
| first1 = S
| title = Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases
| journal = Cell
| volume = 107
| issue = 2
| pages = 173–82
| last2 = Lee
| first2 = J. R.
| last3 = Freeman
| first3 = M
| doi=10.1016/s0092-8674(01)00525-6
}}
*{{Cite journal
| pmid = 22267201
| pmc = 3288642
| year = 2012
| author1 = Stolk
| first1 = L
| title = Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways
| journal = Nature Genetics
| volume = 44
| issue = 3
| pages = 260–8
| last2 = Perry
| first2 = J. R.
| last3 = Chasman
| first3 = D. I.
| last4 = He
| first4 = C
| last5 = Mangino
| first5 = M
| last6 = Sulem
| first6 = P
| last7 = Barbalic
| first7 = M
| last8 = Broer
| first8 = L
| last9 = Byrne
| first9 = E. M.
| last10 = Ernst
| first10 = F
| last11 = Esko
| first11 = T
| last12 = Franceschini
| first12 = N
| last13 = Gudbjartsson
| first13 = D. F.
| last14 = Hottenga
| first14 = J. J.
| last15 = Kraft
| first15 = P
| last16 = McArdle
| first16 = P. F.
| last17 = Porcu
| first17 = E
| last18 = Shin
| first18 = S. Y.
| last19 = Smith
| first19 = A. V.
| last20 = Van Wingerden
| first20 = S
| last21 = Zhai
| first21 = G
| last22 = Zhuang
| first22 = W. V.
| last23 = Albrecht
| first23 = E
| last24 = Alizadeh
| first24 = B. Z.
| last25 = Aspelund
| first25 = T
| last26 = Bandinelli
| first26 = S
| last27 = Lauc
| first27 = L. B.
| last28 = Beckmann
| first28 = J. S.
| last29 = Boban
| first29 = M
| last30 = Boerwinkle
| first30 = E
| display-authors = 29
| doi = 10.1038/ng.1051
}}
*{{Cite journal
| pmid = 19850051
| year = 2009
| author1 = Lei
| first1 = X
| title = The processing of human rhomboid intramembrane serine protease RHBDL2 is required for its proteolytic activity
| journal = Journal of Molecular Biology
| volume = 394
| issue = 5
| pages = 815–25
| last2 = Li
| first2 = Y. M.
| doi = 10.1016/j.jmb.2009.10.025
}}
 
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}


{{gene-1-stub}}
{{gene-1-stub}}

Latest revision as of 10:18, 3 February 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Rhomboid, veinlet-like 2 (Drosophila) is a protein that in humans is encoded by the RHBDL2 gene.[1]

Function

The protein encoded by this gene is a member of the rhomboid family of integral membrane proteins. This family contains proteins that are related to Drosophila rhomboid protein. Members of this family are found in both prokaryotes and eukaryotes and are thought to function as intramembrane serine proteases. The encoded protein is thought to release soluble growth factors by proteolytic cleavage of certain membrane-bound substrates, including ephrin B2 and ephrin B3.

References

  1. ↑ "Entrez Gene: Rhomboid, veinlet-like 2 (Drosophila)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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