SOAT1: Difference between revisions

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*{{cite journal  |vauthors=Chang TY, Chang CC, Lin S, etal |title=Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. |journal=Curr. Opin. Lipidol. |volume=12 |issue= 3 |pages= 289–96 |year= 2001 |pmid= 11353332 |doi=10.1097/00041433-200106000-00008  }}
*{{cite journal  |vauthors=Chang TY, Chang CC, Lin S, etal |title=Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2. |journal=Curr. Opin. Lipidol. |volume=12 |issue= 3 |pages= 289–96 |year= 2001 |pmid= 11353332 |doi=10.1097/00041433-200106000-00008  }}
*{{cite journal  |vauthors=Chang CC, Noll WW, Nutile-McMenemy N, etal |title=Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 1 |pages= 71–4 |year= 1994 |pmid= 8197480 |doi=10.1007/BF02257489  }}
*{{cite journal  |vauthors=Chang CC, Noll WW, Nutile-McMenemy N, etal |title=Localization of acyl coenzyme A:cholesterol acyltransferase gene to human chromosome 1q25. |journal=Somat. Cell Mol. Genet. |volume=20 |issue= 1 |pages= 71–4 |year= 1994 |pmid= 8197480 |doi=10.1007/BF02257489  }}
*{{cite journal  | vauthors=Chang CC, Huh HY, Cadigan KM, Chang TY |title=Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20747–55 |year= 1993 |pmid= 8407899 |doi=  }}
*{{cite journal  | vauthors=Chang CC, Huh HY, Cadigan KM, Chang TY |title=Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells. |journal=J. Biol. Chem. |volume=268 |issue= 28 |pages= 20747–55 |year= 1993 |pmid= 8407899 |doi=  10.1074/jbc.273.52.35132}}
*{{cite journal  |vauthors=Chang CCY, Lee CYG, Chang ET, Cruz JC, Levesque M, Chang TY: Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or vesicles in a  highly cooperative manner.|journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35132–41 |year= 1998 |pmid= 8407899 |doi=  }}
*{{cite journal  |vauthors=Chang CCY, Lee CYG, Chang ET, Cruz JC, Levesque M, Chang TY |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35132–41 |year= 1998 |pmid= 8407899 |doi=  10.1074/jbc.273.52.35132 |title=Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells}}
*{{cite journal  |vauthors=Oelkers P, Behari A, Cromley D, etal |title=Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26765–71 |year= 1998 |pmid= 9756920 |doi=10.1074/jbc.273.41.26765  }}
*{{cite journal  |vauthors=Oelkers P, Behari A, Cromley D, etal |title=Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes. |journal=J. Biol. Chem. |volume=273 |issue= 41 |pages= 26765–71 |year= 1998 |pmid= 9756920 |doi=10.1074/jbc.273.41.26765  }}
*{{cite journal  |vauthors=Li BL, Li XL, Duan ZJ, etal |title=Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11060–71 |year= 1999 |pmid= 10196189 |doi=10.1074/jbc.274.16.11060  }}
*{{cite journal  |vauthors=Li BL, Li XL, Duan ZJ, etal |title=Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 11060–71 |year= 1999 |pmid= 10196189 |doi=10.1074/jbc.274.16.11060  }}

Latest revision as of 10:13, 2 March 2018

Not to be confused with Acetyl-Coenzyme A acetyltransferase.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Wikidata
View/Edit Human

Sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1, also known as SOAT1, is an enzyme that in humans is encoded by the SOAT1 gene.[1]

Function

Acyl-coenzyme A:cholesterol acyltransferase (EC 2.3.1.26) is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from cholesterol. Accumulation of cholesterol esters as cytoplasmic lipid droplets within macrophages and smooth muscle cells is a characteristic feature of the early stages of atherosclerotic plaques (Cadigan et al., 1988).[1]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin Pathway edit
  1. ↑ The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: SOAT1 sterol O-acyltransferase (acyl-Coenzyme A: cholesterol acyltransferase) 1".

Further reading

Template:PBB ng Further readi



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