ATG4D: Difference between revisions
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The human '''ATG4D''' [[gene]] encodes the [[protein]] '''Autophagy related 4D, cysteine peptidase'''.<ref name="entrez">{{cite web | title = Entrez Gene: Autophagy related 4D, cysteine peptidase | url = https://www.ncbi.nlm.nih.gov/gene/84971 }}</ref> | |||
== Function == | |||
==Function== | |||
Autophagy is the process by which endogenous proteins and damaged [[organelles]] are destroyed intracellularly. Autophagy is postulated to be essential for cell [[Human homeostasis|homeostasis]] and cell remodeling during differentiation, [[metamorphosis]], non-[[Apoptosis|apoptotic]] cell death, and aging. Reduced levels of autophagy have been described in some malignant [[Neoplasm|tumor]]s, and a role for autophagy in controlling the unregulated cell growth linked to [[cancer]] has been proposed. | Autophagy is the process by which endogenous proteins and damaged [[organelles]] are destroyed intracellularly. Autophagy is postulated to be essential for cell [[Human homeostasis|homeostasis]] and cell remodeling during differentiation, [[metamorphosis]], non-[[Apoptosis|apoptotic]] cell death, and aging. Reduced levels of autophagy have been described in some malignant [[Neoplasm|tumor]]s, and a role for autophagy in controlling the unregulated cell growth linked to [[cancer]] has been proposed. | ||
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== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
== Further reading == | == Further reading == | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
*{{ | * {{cite journal | vauthors = Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD | title = A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress | journal = Autophagy | volume = 8 | issue = 4 | pages = 664–76 | date = April 2012 | pmid = 22441018 | pmc = 3405841 | doi = 10.4161/auto.19227 }} | ||
* {{cite journal | vauthors = Betin VM, Lane JD | title = Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis | journal = Journal of Cell Science | volume = 122 | issue = Pt 14 | pages = 2554–66 | date = July 2009 | pmid = 19549685 | pmc = 2704886 | doi = 10.1242/jcs.046250 }} | |||
* {{cite journal | vauthors = Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C | title = Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy | journal = The Journal of Biological Chemistry | volume = 278 | issue = 6 | pages = 3671–8 | date = February 2003 | pmid = 12446702 | doi = 10.1074/jbc.M208247200 }} | |||
| title = A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress | |||
| journal = Autophagy | |||
| volume = 8 | |||
| issue = 4 | |||
| pages = 664–76 | |||
| | |||
| | |||
| | |||
| doi = 10.4161/auto.19227 | |||
}} | |||
*{{ | |||
| title = Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis | |||
| journal = Journal of Cell Science | |||
| volume = 122 | |||
| issue = Pt 14 | |||
| pages = 2554–66 | |||
| | |||
| | |||
| doi = 10.1242/jcs.046250 | |||
}} | |||
*{{ | |||
| | |||
| title = Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy | |||
| journal = Journal of Biological Chemistry | |||
| volume = 278 | |||
| issue = 6 | |||
| pages = 3671–8 | |||
| | |||
| | |||
| doi = 10.1074/jbc.M208247200 | |||
}} | |||
{{refend}} | {{refend}} | ||
{{NLM content}} | {{NLM content}} | ||
{{gene-19-stub}} | {{gene-19-stub}} | ||
[[Category:Human proteins]] | [[Category:Human proteins]] |
Latest revision as of 07:50, 27 January 2018
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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The human ATG4D gene encodes the protein Autophagy related 4D, cysteine peptidase.[1]
Function
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.
This gene belongs to the autophagy-related protein 4 (Atg4) family of C54 endopeptidases. Members of this family encode proteins that play a role in the biogenesis of autophagosomes, which sequester the cytosol and organelles for degradation by lysosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
References
Further reading
- Betin VM, MacVicar TD, Parsons SF, Anstee DJ, Lane JD (April 2012). "A cryptic mitochondrial targeting motif in Atg4D links caspase cleavage with mitochondrial import and oxidative stress". Autophagy. 8 (4): 664–76. doi:10.4161/auto.19227. PMC 3405841. PMID 22441018.
- Betin VM, Lane JD (July 2009). "Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis". Journal of Cell Science. 122 (Pt 14): 2554–66. doi:10.1242/jcs.046250. PMC 2704886. PMID 19549685.
- Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C (February 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". The Journal of Biological Chemistry. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it. |