RAC3: Difference between revisions
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*{{cite journal |vauthors=Haataja L, Groffen J, Heisterkamp N |title=Characterization of RAC3, a novel member of the Rho family. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20384–8 |year= 1997 |pmid= 9252344 |doi=10.1074/jbc.272.33.20384 }} | *{{cite journal |vauthors=Haataja L, Groffen J, Heisterkamp N |title=Characterization of RAC3, a novel member of the Rho family. |journal=J. Biol. Chem. |volume=272 |issue= 33 |pages= 20384–8 |year= 1997 |pmid= 9252344 |doi=10.1074/jbc.272.33.20384 }} | ||
*{{cite journal |vauthors=Courjal F, Chuchana P, Theillet C, Fort P |title=Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes. |journal=Genomics |volume=44 |issue= 2 |pages= 242–6 |year= 1997 |pmid= 9299243 |doi= 10.1006/geno.1997.4871 }} | *{{cite journal |vauthors=Courjal F, Chuchana P, Theillet C, Fort P |title=Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes. |journal=Genomics |volume=44 |issue= 2 |pages= 242–6 |year= 1997 |pmid= 9299243 |doi= 10.1006/geno.1997.4871 }} | ||
*{{cite journal |vauthors=Mira JP, Benard V, Groffen J, etal |title=Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 1 |pages= 185–9 |year= 2000 |pmid= 10618392 |doi=10.1073/pnas.97.1.185 | pmc=26637 }} | *{{cite journal |vauthors=Mira JP, Benard V, Groffen J, etal |title=Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 1 |pages= 185–9 |year= 2000 |pmid= 10618392 |doi=10.1073/pnas.97.1.185 | pmc=26637 |bibcode=2000PNAS...97..185M }} | ||
*{{cite journal |vauthors=Soutoglou E, Papafotiou G, Katrakili N, Talianidis I |title=Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12515–20 |year= 2000 |pmid= 10777539 |doi=10.1074/jbc.275.17.12515 }} | *{{cite journal |vauthors=Soutoglou E, Papafotiou G, Katrakili N, Talianidis I |title=Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12515–20 |year= 2000 |pmid= 10777539 |doi=10.1074/jbc.275.17.12515 }} | ||
*{{cite journal |vauthors=Morris CM, Haataja L, McDonald M, etal |title=The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1–2 |pages= 18–23 |year= 2000 |pmid= 10894930 |doi=10.1159/000015583 }} | *{{cite journal |vauthors=Morris CM, Haataja L, McDonald M, etal |title=The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1–2 |pages= 18–23 |year= 2000 |pmid= 10894930 |doi=10.1159/000015583 }} | ||
| Line 28: | Line 28: | ||
*{{cite journal |vauthors=Haataja L, Kaartinen V, Groffen J, Heisterkamp N |title=The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8321–8 |year= 2002 |pmid= 11756406 |doi= 10.1074/jbc.M105363200 }} | *{{cite journal |vauthors=Haataja L, Kaartinen V, Groffen J, Heisterkamp N |title=The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 8321–8 |year= 2002 |pmid= 11756406 |doi= 10.1074/jbc.M105363200 }} | ||
*{{cite journal |vauthors=De Langhe S, Haataja L, Senadheera D, etal |title=Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 451–9 |year= 2002 |pmid= 11956649 |doi= 10.3892/ijmm.9.5.451}} | *{{cite journal |vauthors=De Langhe S, Haataja L, Senadheera D, etal |title=Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain |journal=Int. J. Mol. Med. |volume=9 |issue= 5 |pages= 451–9 |year= 2002 |pmid= 11956649 |doi= 10.3892/ijmm.9.5.451}} | ||
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }} | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal |vauthors=Zhang A, Yeung PL, Li CW, etal |title=Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33799–805 |year= 2004 |pmid= 15184363 |doi= 10.1074/jbc.M403997200 }} | *{{cite journal |vauthors=Zhang A, Yeung PL, Li CW, etal |title=Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33799–805 |year= 2004 |pmid= 15184363 |doi= 10.1074/jbc.M403997200 }} | ||
*{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal |vauthors=Hwang SL, Chang JH, Cheng TS, etal |title=Expression of Rac3 in human brain tumors |journal=Journal of Clinical Neuroscience |volume=12 |issue= 5 |pages= 571–4 |year= 2006 |pmid= 15993075 |doi= 10.1016/j.jocn.2004.08.013 }} | *{{cite journal |vauthors=Hwang SL, Chang JH, Cheng TS, etal |title=Expression of Rac3 in human brain tumors |journal=Journal of Clinical Neuroscience |volume=12 |issue= 5 |pages= 571–4 |year= 2006 |pmid= 15993075 |doi= 10.1016/j.jocn.2004.08.013 }} | ||
*{{cite journal |vauthors=Chan AY, Coniglio SJ, Chuang YY, etal |title=Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion |journal=Oncogene |volume=24 |issue= 53 |pages= 7821–9 |year= 2005 |pmid= 16027728 |doi= 10.1038/sj.onc.1208909 }} | *{{cite journal |vauthors=Chan AY, Coniglio SJ, Chuang YY, etal |title=Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion |journal=Oncogene |volume=24 |issue= 53 |pages= 7821–9 |year= 2005 |pmid= 16027728 |doi= 10.1038/sj.onc.1208909 }} | ||
*{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }} | *{{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }} | ||
*{{cite journal |vauthors=Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF |title=Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells |journal=Breast Cancer Res. |volume=7 |issue= 6 |pages= R965–74 |year= 2006 |pmid= 16280046 |doi= 10.1186/bcr1329 | pmc=1410764 }} | *{{cite journal |vauthors=Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF |title=Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells |journal=Breast Cancer Res. |volume=7 |issue= 6 |pages= R965–74 |year= 2006 |pmid= 16280046 |doi= 10.1186/bcr1329 | pmc=1410764 }} | ||
*{{cite journal |vauthors=Watabe-Uchida M, John KA, Janas JA, etal |title=The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18 |journal=Neuron |volume=51 |issue= 6 |pages= 727–39 |year= 2006 |pmid= 16982419 |doi= 10.1016/j.neuron.2006.07.020 }} | *{{cite journal |vauthors=Watabe-Uchida M, John KA, Janas JA, etal |title=The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18 |journal=Neuron |volume=51 |issue= 6 |pages= 727–39 |year= 2006 |pmid= 16982419 |doi= 10.1016/j.neuron.2006.07.020 }} | ||
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==External links== | ==External links== | ||
*[http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=5881 RAC3] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] | *[https://web.archive.org/web/20110722013626/http://cmkb.cellmigration.org/report.cgi?report=orth_overview&gene_id=5881 RAC3] Info with links in the [http://www.cellmigration.org/index.shtml Cell Migration Gateway] | ||
{{PDB Gallery|geneid=5881}} | {{PDB Gallery|geneid=5881}} | ||
Latest revision as of 01:35, 26 June 2018
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Ras-related C3 botulinum toxin substrate 3 is a protein that in humans is encoded by the RAC3 gene.[1]
The protein encoded by this gene is a GTPase that belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases.[1]
Interactions
RAC3 has been shown to interact with CIB1[2] and HNF1A.[3]
References
- ↑ 1.0 1.1 "Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)".
- ↑ Haataja, Leena; Kaartinen Vesa; Groffen John; Heisterkamp Nora (March 2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. United States. 277 (10): 8321–8. doi:10.1074/jbc.M105363200. ISSN 0021-9258. PMID 11756406.
yes
- ↑ Soutoglou, E; Papafotiou G; Katrakili N; Talianidis I (April 2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. UNITED STATES. 275 (17): 12515–20. doi:10.1074/jbc.275.17.12515. ISSN 0021-9258. PMID 10777539.
yes
Further reading
- Didsbury J, Weber RF, Bokoch GM, et al. (1989). "rac, a novel ras-related family of proteins that are botulinum toxin substrates". J. Biol. Chem. 264 (28): 16378–82. PMID 2674130.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Haataja L, Groffen J, Heisterkamp N (1997). "Characterization of RAC3, a novel member of the Rho family". J. Biol. Chem. 272 (33): 20384–8. doi:10.1074/jbc.272.33.20384. PMID 9252344.
- Courjal F, Chuchana P, Theillet C, Fort P (1997). "Structure and chromosomal assignment to 22q12 and 17qter of the ras-related Rac2 and Rac3 human genes". Genomics. 44 (2): 242–6. doi:10.1006/geno.1997.4871. PMID 9299243.
- Mira JP, Benard V, Groffen J, et al. (2000). "Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway". Proc. Natl. Acad. Sci. U.S.A. 97 (1): 185–9. Bibcode:2000PNAS...97..185M. doi:10.1073/pnas.97.1.185. PMC 26637. PMID 10618392.
- Soutoglou E, Papafotiou G, Katrakili N, Talianidis I (2000). "Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins". J. Biol. Chem. 275 (17): 12515–20. doi:10.1074/jbc.275.17.12515. PMID 10777539.
- Morris CM, Haataja L, McDonald M, et al. (2000). "The small GTPase RAC3 gene is located within chromosome band 17q25.3 outside and telomeric of a region commonly deleted in breast and ovarian tumours". Cytogenet. Cell Genet. 89 (1–2): 18–23. doi:10.1159/000015583. PMID 10894930.
- Gnanapragasam VJ, Leung HY, Pulimood AS, et al. (2002). "Expression of RAC 3, a steroid hormone receptor co-activator in prostate cancer". Br. J. Cancer. 85 (12): 1928–36. doi:10.1054/bjoc.2001.2179. PMC 2364015. PMID 11747336.
- Haataja L, Kaartinen V, Groffen J, Heisterkamp N (2002). "The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreading". J. Biol. Chem. 277 (10): 8321–8. doi:10.1074/jbc.M105363200. PMID 11756406.
- De Langhe S, Haataja L, Senadheera D, et al. (2002). "Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain". Int. J. Mol. Med. 9 (5): 451–9. doi:10.3892/ijmm.9.5.451. PMID 11956649.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Zhang A, Yeung PL, Li CW, et al. (2004). "Identification of a novel family of ankyrin repeats containing cofactors for p160 nuclear receptor coactivators". J. Biol. Chem. 279 (32): 33799–805. doi:10.1074/jbc.M403997200. PMID 15184363.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hwang SL, Chang JH, Cheng TS, et al. (2006). "Expression of Rac3 in human brain tumors". Journal of Clinical Neuroscience. 12 (5): 571–4. doi:10.1016/j.jocn.2004.08.013. PMID 15993075.
- Chan AY, Coniglio SJ, Chuang YY, et al. (2005). "Roles of the Rac1 and Rac3 GTPases in human tumor cell invasion". Oncogene. 24 (53): 7821–9. doi:10.1038/sj.onc.1208909. PMID 16027728.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
- Baugher PJ, Krishnamoorthy L, Price JE, Dharmawardhane SF (2006). "Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells". Breast Cancer Res. 7 (6): R965–74. doi:10.1186/bcr1329. PMC 1410764. PMID 16280046.
- Watabe-Uchida M, John KA, Janas JA, et al. (2006). "The Rac activator DOCK7 regulates neuronal polarity through local phosphorylation of stathmin/Op18". Neuron. 51 (6): 727–39. doi:10.1016/j.neuron.2006.07.020. PMID 16982419.
- Hajdo-Milasinović A, Ellenbroek SI, van Es S, et al. (2007). "Rac1 and Rac3 have opposing functions in cell adhesion and differentiation of neuronal cells". J. Cell Sci. 120 (Pt 4): 555–66. doi:10.1242/jcs.03364. PMID 17244648.
External links
- RAC3 Info with links in the Cell Migration Gateway
 | This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it. |