Myopodin is a 117.4 kDa protein composed of 1093 amino acids,<ref>{{cite web|url=http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=Q9UMS6|title=Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) —— Protein Information|author=Joon-Sub Chung|work=heartproteome.org}}</ref> although four alternatively-spliced isoforms have been described.<ref>{{cite web|url=http://www.uniprot.org/uniprot/Q9UMS6|title=SYNPO2 - Synaptopodin-2 - Homo sapiens (Human) - SYNPO2 gene & protein|work=uniprot.org}}</ref> Myopodin contains one PPXY motif, multiple PXXP motifs, and two potential [[nuclear localization sequence]]s (one [[N-terminus|N-terminal]] and one [[C-terminus|C-terminal]]).<ref name="pmid11673475" /> PPXY motifs have been shown to mediate [[protein–protein interactions|interactions]], and PXXP motifs represent potential sites of [[protein-protein interaction|interaction]] for [[SH3 domain]]-containing proteins. Myopodin contains a novel [[ACTC1|actin]] binding site (between amino acids 410 and 563) in the center of the protein.<ref name="pmid11673475" />
Myopodin is a 117.4 kDa protein composed of 1093 amino acids,<ref>{{cite web|url=http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=Q9UMS6|title=Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) —— Protein Information|author=Joon-Sub Chung|work=heartproteome.org}}</ref> although four alternatively-spliced isoforms have been described.<ref>{{cite web|url=https://www.uniprot.org/uniprot/Q9UMS6|title=SYNPO2 - Synaptopodin-2 - Homo sapiens (Human) - SYNPO2 gene & protein|work=uniprot.org}}</ref> Myopodin contains one PPXY motif, multiple PXXP motifs, and two potential [[nuclear localization sequence]]s (one [[N-terminus|N-terminal]] and one [[C-terminus|C-terminal]]).<ref name="pmid11673475" /> PPXY motifs have been shown to mediate [[protein–protein interactions|interactions]], and PXXP motifs represent potential sites of [[protein-protein interaction|interaction]] for [[SH3 domain]]-containing proteins. Myopodin contains a novel [[ACTC1|actin]] binding site (between amino acids 410 and 563) in the center of the protein.<ref name="pmid11673475" />
Myopodin is a 117.4 kDa protein composed of 1093 amino acids,[4] although four alternatively-spliced isoforms have been described.[5] Myopodin contains one PPXY motif, multiple PXXP motifs, and two potential nuclear localization sequences (one N-terminal and one C-terminal).[1] PPXY motifs have been shown to mediate interactions, and PXXP motifs represent potential sites of interaction for SH3 domain-containing proteins. Myopodin contains a novel actin binding site (between amino acids 410 and 563) in the center of the protein.[1]
↑Liang J, Ke G, You W, Peng Z, Lan J, Kalesse M, Tartakoff AM, Kaplan F, Tao T (Jan 2008). "Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin". Molecular and Cellular Biochemistry. 307 (1–2): 93–100. doi:10.1007/s11010-007-9588-1. PMID17828378.
↑ 6.06.1Liang J, Ke G, You W, Peng Z, Lan J, Kalesse M, Tartakoff AM, Kaplan F, Tao T (Jan 2008). "Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin". Molecular and Cellular Biochemistry. 307 (1–2): 93–100. doi:10.1007/s11010-007-9588-1. PMID17828378.
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Van Impe K, De Corte V, Eichinger L, Bruyneel E, Mareel M, Vandekerckhove J, Gettemans J (May 2003). "The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins". The Journal of Biological Chemistry. 278 (20): 17945–52. doi:10.1074/jbc.M209946200. PMID12637565.
Sanchez-Carbayo M, Schwarz K, Charytonowicz E, Cordon-Cardo C, Mundel P (Aug 2003). "Tumor suppressor role for myopodin in bladder cancer: loss of nuclear expression of myopodin is cell-cycle dependent and predicts clinical outcome". Oncogene. 22 (34): 5298–305. doi:10.1038/sj.onc.1206616. PMID12917631.
