CPNE1: Difference between revisions

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{{Infobox_gene}}
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'''Copine-1''' is a [[protein]] that in humans is encoded by the ''CPNE1'' [[gene]].<ref name="pmid9430674">{{cite journal | vauthors = Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J | title = The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans | journal = J Biol Chem | volume = 273 | issue = 3 | pages = 1393–402 |date=Feb 1998 | pmid = 9430674 | pmc =  | doi =10.1074/jbc.273.3.1393  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CPNE1 copine I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8904| accessdate = }}</ref>
'''Copine-1''' is a [[protein]] that in humans is encoded by the ''CPNE1'' [[gene]].<ref name="pmid9430674">{{cite journal | vauthors = Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J | title = The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans | journal = J Biol Chem | volume = 273 | issue = 3 | pages = 1393–402 |date=Feb 1998 | pmid = 9430674 | pmc =  | doi =10.1074/jbc.273.3.1393  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CPNE1 copine I| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8904| accessdate = }}</ref>
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{{PBB_Summary
{{PBB_Summary
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| summary_text = Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.<ref name="entrez" />
| summary_text = [[Calcium]]-dependent [[membrane protein|membrane-binding proteins]] may regulate molecular events at the interface of the [[cell membrane]] and [[cytoplasm]]. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the [[C-terminus]]. However, the encoded protein does not contain a predicted signal sequence or [[transmembrane domains]]. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for [[RNA]] binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple [[alternatively spliced]] variants in the 5' UTR. All variants encode the same protein.<ref name="entrez" />
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Revision as of 16:01, 19 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Copine-1 is a protein that in humans is encoded by the CPNE1 gene.[1][2]

Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene encodes a calcium-dependent protein that also contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, the encoded protein does not contain a predicted signal sequence or transmembrane domains. This protein has a broad tissue distribution and it may function in membrane trafficking. This gene and the gene for RNA binding motif protein 12 overlap at map location 20q11.21. Sequence analysis identified multiple alternatively spliced variants in the 5' UTR. All variants encode the same protein.[2]

References

  1. Creutz CE, Tomsig JL, Snyder SL, Gautier MC, Skouri F, Beisson J, Cohen J (Feb 1998). "The copines, a novel class of C2 domain-containing, calcium-dependent, phospholipid-binding proteins conserved from Paramecium to humans". J Biol Chem. 273 (3): 1393–402. doi:10.1074/jbc.273.3.1393. PMID 9430674.
  2. 2.0 2.1 "Entrez Gene: CPNE1 copine I".

External links

Further reading