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==Pathophysiology== | ==Pathophysiology== | ||
* The main pathological feature of Hogkin's lymphoma is the Reed-Sternberg cells which is created mainly due to activation of the nuclear factor kappa B (NF-kB) transcription factor-signaling pathway. The improper activation of the (NF-kB) system proteins is correlated with many neoplasms. | * The main pathological feature of Hogkin's lymphoma is the Reed-Sternberg cells which is created mainly due to activation of the nuclear factor kappa B (NF-kB) transcription factor-signaling pathway. The improper activation of the (NF-kB) system proteins is correlated with many neoplasms.<ref name="pmid15164877">{{cite journal| author=Shishodia S, Aggarwal BB| title=Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. | journal=Cancer Treat Res | year= 2004 | volume= 119 | issue= | pages= 139-73 | pmid=15164877 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15164877 }}</ref> | ||
* NF-kB is degraded normally by "I kappa B (IkB)" family in order to prevent the unwanted stimulation and neoplasm formation. However, there are specific cellular proteins which lead to inactivation of the (IkB). So, by inactivating the (IkB), the NF-kB transcription factors will not be degraded and leads to gene transcriptions activation. | * NF-kB is degraded normally by "I kappa B (IkB)" family in order to prevent the unwanted stimulation and neoplasm formation. However, there are specific cellular proteins which lead to inactivation of the (IkB). So, by inactivating the (IkB), the NF-kB transcription factors will not be degraded and leads to gene transcriptions activation.<ref name="pmid151648772">{{cite journal| author=Shishodia S, Aggarwal BB| title=Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. | journal=Cancer Treat Res | year= 2004 | volume= 119 | issue= | pages= 139-73 | pmid=15164877 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15164877 }}</ref> | ||
* In Hodgkin's lymphoma, there are elevated levels of the NF-kB proteins especially c-REL and REL-A.<ref name="pmid9597130">{{cite journal| author=Ghosh S, May MJ, Kopp EB| title=NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | journal=Annu Rev Immunol | year= 1998 | volume= 16 | issue= | pages= 225-60 | pmid=9597130 | doi=10.1146/annurev.immunol.16.1.225 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9597130 }}</ref> | * In Hodgkin's lymphoma, there are elevated levels of the NF-kB proteins especially c-REL and REL-A.<ref name="pmid9597130">{{cite journal| author=Ghosh S, May MJ, Kopp EB| title=NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. | journal=Annu Rev Immunol | year= 1998 | volume= 16 | issue= | pages= 225-60 | pmid=9597130 | doi=10.1146/annurev.immunol.16.1.225 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9597130 }}</ref> | ||
* | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 17:59, 28 August 2018
Pathophysiology
- The main pathological feature of Hogkin's lymphoma is the Reed-Sternberg cells which is created mainly due to activation of the nuclear factor kappa B (NF-kB) transcription factor-signaling pathway. The improper activation of the (NF-kB) system proteins is correlated with many neoplasms.[1]
- NF-kB is degraded normally by "I kappa B (IkB)" family in order to prevent the unwanted stimulation and neoplasm formation. However, there are specific cellular proteins which lead to inactivation of the (IkB). So, by inactivating the (IkB), the NF-kB transcription factors will not be degraded and leads to gene transcriptions activation.[2]
- In Hodgkin's lymphoma, there are elevated levels of the NF-kB proteins especially c-REL and REL-A.[3]
References
- ↑ Shishodia S, Aggarwal BB (2004). "Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer". Cancer Treat Res. 119: 139–73. PMID 15164877.
- ↑ Shishodia S, Aggarwal BB (2004). "Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer". Cancer Treat Res. 119: 139–73. PMID 15164877.
- ↑ Ghosh S, May MJ, Kopp EB (1998). "NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses". Annu Rev Immunol. 16: 225–60. doi:10.1146/annurev.immunol.16.1.225. PMID 9597130.