Multiple myeloma historical perspective: Difference between revisions

Jump to navigation Jump to search
No edit summary
Line 1: Line 1:
__NOTOC__
__NOTOC__
{{Multiple myeloma}}
{{Multiple myeloma}}
{{CMG}} {{AE}}{{HL}}
{{CMG}} {{AE}}{{HL}} {{shyam}}


==Overview==
==Overview==
Line 7: Line 7:


==Historical Perspective==
==Historical Perspective==
*In '''1844''', Dr. Samuel Solly first discovered multiple myeloma. He was a a surgeon working in St.Thomas hospital at London.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref>
*In '''1844''', Dr. Samuel Solly reported the first case of multiple myeloma. He was a a surgeon working in St.Thomas hospital at London.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref><ref name="pmid18332230">{{cite journal| author=Kyle RA, Rajkumar SV| title=Multiple myeloma. | journal=Blood | year= 2008 | volume= 111 | issue= 6 | pages= 2962-72 | pmid=18332230 | doi=10.1182/blood-2007-10-078022 | pmc=2265446 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18332230  }} </ref> Dr. Solly treated patients with rhubard and orange peel.
*In '''1845''', abnormal urinary proteins were found to be associated with multiple myeloma. These were eventually coined as Bence Jones proteins. Dr. T. Watson treated patients with steel and quinine.
*In '''1850''', Dr. Henry Bence Jones first described the Bence Jones protein and found it to be associated with multiple myeloma.<ref name="pmid21509678">{{cite journal| author=Kyle RA, Steensma DP| title=History of multiple myeloma. | journal=Recent Results Cancer Res | year= 2011 | volume= 183 | issue=  | pages= 3-23 | pmid=21509678 | doi=10.1007/978-3-540-85772-3_1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21509678  }} </ref>
*In '''1850''', Dr. Henry Bence Jones first described the Bence Jones protein and found it to be associated with multiple myeloma.<ref name="pmid21509678">{{cite journal| author=Kyle RA, Steensma DP| title=History of multiple myeloma. | journal=Recent Results Cancer Res | year= 2011 | volume= 183 | issue=  | pages= 3-23 | pmid=21509678 | doi=10.1007/978-3-540-85772-3_1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21509678  }} </ref>
*In '''1895''', plasma cells were first described. It was later found that plasma cell proliferation was the cellular basis for multiple myeloma.<ref name="pmid18332230">{{cite journal| author=Kyle RA, Rajkumar SV| title=Multiple myeloma. | journal=Blood | year= 2008 | volume= 111 | issue= 6 | pages= 2962-72 | pmid=18332230 | doi=10.1182/blood-2007-10-078022 | pmc=2265446 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18332230  }} </ref>
*In '''1928''', the first large case series of multiple myeloma patients was reported.<ref name="pmid18332230">{{cite journal| author=Kyle RA, Rajkumar SV| title=Multiple myeloma. | journal=Blood | year= 2008 | volume= 111 | issue= 6 | pages= 2962-72 | pmid=18332230 | doi=10.1182/blood-2007-10-078022 | pmc=2265446 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18332230  }} </ref>
*In '''1939''', the monoclonal protein spike (M-spike) was described on protein electrophoresis. The M-spike was noted to be the gamma-globulin region.<ref name="pmid18332230">{{cite journal| author=Kyle RA, Rajkumar SV| title=Multiple myeloma. | journal=Blood | year= 2008 | volume= 111 | issue= 6 | pages= 2962-72 | pmid=18332230 | doi=10.1182/blood-2007-10-078022 | pmc=2265446 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18332230  }} </ref>
*In '''1947''', Dr. N. Alwall treated multiple myeloma patients with urethane.
*In '''1956''', light chains were recognized to be a component of multiple myeloma.<ref name="pmid18332230">{{cite journal| author=Kyle RA, Rajkumar SV| title=Multiple myeloma. | journal=Blood | year= 2008 | volume= 111 | issue= 6 | pages= 2962-72 | pmid=18332230 | doi=10.1182/blood-2007-10-078022 | pmc=2265446 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18332230  }} </ref>
*In the '''1960s''', the chemotherapy agent [[melphalan]] was shown to improve overall survival in multiple myeloma.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In the '''1960s''', the chemotherapy agent [[melphalan]] was shown to improve overall survival in multiple myeloma.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In '''1958''', Dr. N. Blokhin first used melphalan as a chemotherapy agent to treat multiple myeloma.<ref name="pmid18332230">{{cite journal| author=Kyle RA, Rajkumar SV| title=Multiple myeloma. | journal=Blood | year= 2008 | volume= 111 | issue= 6 | pages= 2962-72 | pmid=18332230 | doi=10.1182/blood-2007-10-078022 | pmc=2265446 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18332230  }} </ref>
*In '''1961''', the use of thalidomide was prohibited since it was found to be associated with birth defects.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In '''1961''', the use of thalidomide was prohibited since it was found to be associated with birth defects.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In '''1962''',
*In the 1990s, it was shown that high-dose therapy with autologous stem cell rescue led to improved patient outcomes.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In the 1990s, it was shown that high-dose therapy with autologous stem cell rescue led to improved patient outcomes.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In '''1999''', Singhal and colleagues showed that thalidomide had a 32% response rate in a phase II clinical trial of relapsed/refractory multiple myeloma.
*In '''1999''', Singhal and colleagues showed that thalidomide had a 32% response rate in a phase II clinical trial of relapsed/refractory multiple myeloma.

Revision as of 23:22, 14 July 2018

Multiple myeloma Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Multiple Myeloma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

Staging

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X Ray

Echocardiograph and Ultrasound

CT

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Multiple myeloma historical perspective On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Multiple myeloma historical perspective

All Images
X-rays
Echo and Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Multiple myeloma historical perspective

CDC on Multiple myeloma historical perspective

Multiple myeloma historical perspective in the news

Blogs on Multiple myeloma historical perspective

Directions to Hospitals Treating Multiple myeloma

Risk calculators and risk factors for Multiple myeloma historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2] Shyam Patel [3]

Overview

Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital in London in 1844.[1]The Bence Jones protein was first discovered by Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850; And  the  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880. PMID:29194778

Historical Perspective

  • In 1844, Dr. Samuel Solly reported the first case of multiple myeloma. He was a a surgeon working in St.Thomas hospital at London.[2][3] Dr. Solly treated patients with rhubard and orange peel.
  • In 1845, abnormal urinary proteins were found to be associated with multiple myeloma. These were eventually coined as Bence Jones proteins. Dr. T. Watson treated patients with steel and quinine.
  • In 1850, Dr. Henry Bence Jones first described the Bence Jones protein and found it to be associated with multiple myeloma.[4]
  • In 1895, plasma cells were first described. It was later found that plasma cell proliferation was the cellular basis for multiple myeloma.[3]
  • In 1928, the first large case series of multiple myeloma patients was reported.[3]
  • In 1939, the monoclonal protein spike (M-spike) was described on protein electrophoresis. The M-spike was noted to be the gamma-globulin region.[3]
  • In 1947, Dr. N. Alwall treated multiple myeloma patients with urethane.
  • In 1956, light chains were recognized to be a component of multiple myeloma.[3]
  • In the 1960s, the chemotherapy agent melphalan was shown to improve overall survival in multiple myeloma.[5]
  • In 1958, Dr. N. Blokhin first used melphalan as a chemotherapy agent to treat multiple myeloma.[3]
  • In 1961, the use of thalidomide was prohibited since it was found to be associated with birth defects.[5]
  • In 1962,
  • In the 1990s, it was shown that high-dose therapy with autologous stem cell rescue led to improved patient outcomes.[5]
  • In 1999, Singhal and colleagues showed that thalidomide had a 32% response rate in a phase II clinical trial of relapsed/refractory multiple myeloma.
  • In 2003, the proteasome inhibitor bortezomib was approved by the U.S. Food and Drug Administration for the treatment of multiple myeloma.
  • In 2014, the International Myeloma Working Group (IMWG) revised the diagnostic criteria for active multiple myeloma to include bone marrow plasma cell burden > 60%, serum free light chain ratio > 100, and greater than 1 bony lesion on MRI.

References

  1. Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729
  2. Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729
  3. 3.0 3.1 3.2 3.3 3.4 3.5 Kyle RA, Rajkumar SV (2008). "Multiple myeloma". Blood. 111 (6): 2962–72. doi:10.1182/blood-2007-10-078022. PMC 2265446. PMID 18332230.
  4. Kyle RA, Steensma DP (2011). "History of multiple myeloma". Recent Results Cancer Res. 183: 3–23. doi:10.1007/978-3-540-85772-3_1. PMID 21509678.
  5. 5.0 5.1 5.2 Hong J, Lee JH (2016). "Recent advances in multiple myeloma: a Korean perspective". Korean J Intern Med. 31 (5): 820–34. doi:10.3904/kjim.2015.408. PMC 5016289. PMID 27604794.


Template:WikiDoc Sources