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==Historical Perspective==
==Historical Perspective==
*Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital at London in 1844.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref>
*In '''1844''', Dr. Samuel Solly first discovered multiple myeloma. He was a a surgeon working in St.Thomas hospital at London.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref>
*The Bence Jones protein was first discovered by  Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850.<ref name="pmid21509678">{{cite journal| author=Kyle RA, Steensma DP| title=History of multiple myeloma. | journal=Recent Results Cancer Res | year= 2011 | volume= 183 | issue=  | pages= 3-23 | pmid=21509678 | doi=10.1007/978-3-540-85772-3_1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21509678  }} </ref>
*In '''1850''', Dr. Henry Bence Jones first described the Bence Jones protein and found it to be associated with multiple myeloma.<ref name="pmid21509678">{{cite journal| author=Kyle RA, Steensma DP| title=History of multiple myeloma. | journal=Recent Results Cancer Res | year= 2011 | volume= 183 | issue=  | pages= 3-23 | pmid=21509678 | doi=10.1007/978-3-540-85772-3_1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21509678  }} </ref>
*The  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880.
*In the '''1960s''', the chemotherapy agent [[melphalan]] was shown to improve overall survival in multiple myeloma.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In '''1961''', the use of thalidomide was prohibited since it was found to be associated with birth defects.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In the 1990s, it was shown that high-dose therapy with autologous stem cell rescue led to improved patient outcomes.<ref name="pmid27604794">{{cite journal| author=Hong J, Lee JH| title=Recent advances in multiple myeloma: a Korean perspective. | journal=Korean J Intern Med | year= 2016 | volume= 31 | issue= 5 | pages= 820-34 | pmid=27604794 | doi=10.3904/kjim.2015.408 | pmc=5016289 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27604794  }} </ref>
*In '''1999''', Singhal and colleagues showed


== References ==
== References ==

Revision as of 22:50, 14 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital in London in 1844.[1]The Bence Jones protein was first discovered by Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850; And  the  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880. PMID:29194778

Historical Perspective

  • In 1844, Dr. Samuel Solly first discovered multiple myeloma. He was a a surgeon working in St.Thomas hospital at London.[2]
  • In 1850, Dr. Henry Bence Jones first described the Bence Jones protein and found it to be associated with multiple myeloma.[3]
  • In the 1960s, the chemotherapy agent melphalan was shown to improve overall survival in multiple myeloma.[4]
  • In 1961, the use of thalidomide was prohibited since it was found to be associated with birth defects.[4]
  • In the 1990s, it was shown that high-dose therapy with autologous stem cell rescue led to improved patient outcomes.[4]
  • In 1999, Singhal and colleagues showed

References

  1. Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729
  2. Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729
  3. Kyle RA, Steensma DP (2011). "History of multiple myeloma". Recent Results Cancer Res. 183: 3–23. doi:10.1007/978-3-540-85772-3_1. PMID 21509678.
  4. 4.0 4.1 4.2 Hong J, Lee JH (2016). "Recent advances in multiple myeloma: a Korean perspective". Korean J Intern Med. 31 (5): 820–34. doi:10.3904/kjim.2015.408. PMC 5016289. PMID 27604794.


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