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==Overview==
==Overview==
Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital in London in 1844.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref>
Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital in London in 1844.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref>The Bence Jones protein was first discovered by  Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850; And  the  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880. PMID:29194778
 
In 1847, Bence Jones reported his premortem findings in a short
 
note in the Lancet. A year later, he published a definitive paper on his laboratory findings with a detailed description of the technique he had used to analyze the urine. In 1850, MacIntyre summarized the case from the clinician’s point of view. At that  time,  albuminuria  was  the  term  used  nonspecifically  to  mean  proteinuria,  while  the  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880. In 1898, Weber postulated that the bone marrow is the site of production of the Bence Jones protein. In 1917 and 1921, respectively,  Jacobson  and  Walters  recognized  Bence  Jones  proteins
 
PMID:
: 29194778


==Historical Perspective==
==Historical Perspective==
*Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital at London in 1844.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref>
*Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital at London in 1844.<ref>Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729 </ref>
*The Bence Jones protein was first discovered by  Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850.<ref name="pmid21509678">{{cite journal| author=Kyle RA, Steensma DP| title=History of multiple myeloma. | journal=Recent Results Cancer Res | year= 2011 | volume= 183 | issue=  | pages= 3-23 | pmid=21509678 | doi=10.1007/978-3-540-85772-3_1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21509678  }} </ref>
*The Bence Jones protein was first discovered by  Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850.<ref name="pmid21509678">{{cite journal| author=Kyle RA, Steensma DP| title=History of multiple myeloma. | journal=Recent Results Cancer Res | year= 2011 | volume= 183 | issue=  | pages= 3-23 | pmid=21509678 | doi=10.1007/978-3-540-85772-3_1 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21509678  }} </ref>
*The  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880.


== References ==
== References ==

Revision as of 14:54, 2 June 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Haytham Allaham, M.D. [2]

Overview

Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital in London in 1844.[1]The Bence Jones protein was first discovered by Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850; And  the  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880. PMID:29194778

Historical Perspective

  • Multiple myeloma was first discovered by Dr. Samuel Solly, a surgeon working in St.Thomas hospital at London in 1844.[2]
  • The Bence Jones protein was first discovered by Dr. Henry Bence Jones and found to be associated with multiple myeloma in 1850.[3]
  • The  term  “Bence  Jones  protein”  was  first  used  by Fleischer in 1880.

References

  1. Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729
  2. Moehler T, Goldschmidt H. Multiple Myeloma. Springer Science & Business Media; 2011. https://books.google.com/books?isbn=3540857729
  3. Kyle RA, Steensma DP (2011). "History of multiple myeloma". Recent Results Cancer Res. 183: 3–23. doi:10.1007/978-3-540-85772-3_1. PMID 21509678.


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