Gallbladder cancer pathophysiology: Difference between revisions
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== Overview == | == Overview == | ||
It is thought that gallbladder cancer | It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation. | ||
== Pathophysiology == | == Pathophysiology == | ||
=== | === Chronic inflammation: === | ||
* It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder | * It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder | ||
* In most of patients (>75%), the nidus of this chronic inflammation is gallstones. | * In most of patients (>75%), the nidus of this chronic inflammation is gallstones. | ||
*Gallbladder cancer affects most commonly females 2-3 times than males<ref name="pmid11760569">{{cite journal |vauthors=Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, Alonso de Ruiz P, Aristi Urista G, Nervi F |title=Epidemiology and molecular pathology of gallbladder cancer |journal=CA Cancer J Clin |volume=51 |issue=6 |pages=349–64 |year=2001 |pmid=11760569 |doi= |url=}}</ref> | *Gallbladder cancer affects most commonly females 2-3 times than males<ref name="pmid11760569">{{cite journal |vauthors=Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, Alonso de Ruiz P, Aristi Urista G, Nervi F |title=Epidemiology and molecular pathology of gallbladder cancer |journal=CA Cancer J Clin |volume=51 |issue=6 |pages=349–64 |year=2001 |pmid=11760569 |doi= |url=}}</ref> | ||
* | *In carcinogenesis of gallbladder cancer, Chronic inflammation is directly propotional to malignant transformation | ||
*Chronic inflammation leads to deoxyribonucleic acid (DNA) damage, Releasing cytokines and growth factor in response to inflamation predispose to malignant transformation | |||
== References == | |||
<references /> | |||
Revision as of 19:23, 16 January 2018
Overview
It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.
Pathophysiology
Chronic inflammation:
- It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder
- In most of patients (>75%), the nidus of this chronic inflammation is gallstones.
- Gallbladder cancer affects most commonly females 2-3 times than males[1]
- In carcinogenesis of gallbladder cancer, Chronic inflammation is directly propotional to malignant transformation
- Chronic inflammation leads to deoxyribonucleic acid (DNA) damage, Releasing cytokines and growth factor in response to inflamation predispose to malignant transformation