Gallbladder cancer pathophysiology: Difference between revisions
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=== Pathogenesis === | === Pathogenesis === | ||
* It is understood that gallbladder cancer is the result of | * It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder | ||
* | * In most of patients (>75%), the nidus of this chronic inflammation is gallstones. | ||
*Gallbladder cancer affects most commonly females 2-3 times than males<ref name="pmid11760569">{{cite journal |vauthors=Lazcano-Ponce EC, Miquel JF, Muñoz N, Herrero R, Ferrecio C, Wistuba II, Alonso de Ruiz P, Aristi Urista G, Nervi F |title=Epidemiology and molecular pathology of gallbladder cancer |journal=CA Cancer J Clin |volume=51 |issue=6 |pages=349–64 |year=2001 |pmid=11760569 |doi= |url=}}</ref> | |||
*The hormone estrogen in females causes super saturation in bile and increases the risk of gallstone mediated GBC pathogenesis | |||
Revision as of 16:08, 16 January 2018
Overview
It is thought that gallbladder cancer is the result of chronic irritation of the gallbladder mucosa over a duration of years may predispose to malignant transformation.
Pathophysiology
Pathogenesis
- It is understood that gallbladder cancer is the result of chronic irritation or inflmation of the gallbladder
- In most of patients (>75%), the nidus of this chronic inflammation is gallstones.
- Gallbladder cancer affects most commonly females 2-3 times than males[1]
- The hormone estrogen in females causes super saturation in bile and increases the risk of gallstone mediated GBC pathogenesis