GPM6B: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Neuronal membrane glycoprotein M6-b''' is a [[protein]] that in humans is encoded by the ''GPM6B'' [[gene]].<ref name="pmid8661015">{{cite journal |vauthors=Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V | title = Chromosomal mapping of the human M6 genes | journal = Genomics | volume = 33 | issue = 3 | pages = 532–6 |date=Sep 1996 | pmid = 8661015 | pmc = | doi = 10.1006/geno.1996.0231 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GPM6B glycoprotein M6B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2824| accessdate = }}</ref>
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In melanocytic cells GPM6B gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal |vauthors=Hoek KS, Schlegel NC, Eichhoff OM | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x |display-authors=etal}}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Glycoprotein M6B
| HGNCid = 4461
| Symbol = GPM6B
| AltSymbols =; M6B; MGC17150; MGC54284
| OMIM = 300051
| ECnumber = 
| Homologene = 56966
| MGIid = 107672
| GeneAtlas_image1 = PBB_GE_GPM6B_209168_at_tn.png
| GeneAtlas_image2 = PBB_GE_GPM6B_209169_at_tn.png
| GeneAtlas_image3 = PBB_GE_GPM6B_209167_at_tn.png
| Function = {{GNF_GO|id=GO:0003674 |text = molecular_function}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2824
    | Hs_Ensembl = ENSG00000046653
    | Hs_RefseqProtein = NP_001001994
    | Hs_RefseqmRNA = NM_001001994
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 13698983
    | Hs_GenLoc_end = 13745386
    | Hs_Uniprot = Q13491
    | Mm_EntrezGene = 14758
    | Mm_Ensembl = ENSMUSG00000031342
    | Mm_RefseqmRNA = NM_023122
    | Mm_RefseqProtein = NP_075611
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 161583077
    | Mm_GenLoc_end = 161733093
    | Mm_Uniprot = Q3US81
  }}
}}
'''Glycoprotein M6B''', also known as '''GPM6B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GPM6B glycoprotein M6B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2824| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Yan Y, Lagenaur C, Narayanan V |title=Molecular cloning of M6: identification of a PLP/DM20 gene family. |journal=Neuron |volume=11 |issue= 3 |pages= 423-31 |year= 1993 |pmid= 8398137 |doi=  }}
*{{cite journal  |vauthors=Yan Y, Lagenaur C, Narayanan V |title=Molecular cloning of M6: identification of a PLP/DM20 gene family. |journal=Neuron |volume=11 |issue= 3 |pages= 423–31 |year= 1993 |pmid= 8398137 |doi=10.1016/0896-6273(93)90147-J  }}
*{{cite journal  | author=Olinsky S, Loop BT, DeKosky A, ''et al.'' |title=Chromosomal mapping of the human M6 genes. |journal=Genomics |volume=33 |issue= 3 |pages= 532-6 |year= 1996 |pmid= 8661015 |doi= 10.1006/geno.1996.0231 }}
*{{cite journal  |vauthors=Narayanan V, Olinsky S, Dahle E |title=Mutation analysis of the M6b gene in patients with Rett syndrome. |journal=Am. J. Med. Genet. |volume=78 |issue= 2 |pages= 165–8 |year= 1998 |pmid= 9674909 |doi=10.1002/(SICI)1096-8628(19980630)78:2<165::AID-AJMG13>3.0.CO;2-L |display-authors=etal}}
*{{cite journal  | author=Narayanan V, Olinsky S, Dahle E, ''et al.'' |title=Mutation analysis of the M6b gene in patients with Rett syndrome. |journal=Am. J. Med. Genet. |volume=78 |issue= 2 |pages= 165-8 |year= 1998 |pmid= 9674909 |doi=  }}
*{{cite journal  |vauthors=Yoshida M, Shan WS, Colman DR |title=Conserved and divergent expression patterns of the proteolipid protein gene family in the amphibian central nervous system. |journal=J. Neurosci. Res. |volume=57 |issue= 1 |pages= 13–22 |year= 1999 |pmid= 10397631 |doi=10.1002/(SICI)1097-4547(19990701)57:1<13::AID-JNR2>3.0.CO;2-E }}
*{{cite journal  | author=Yoshida M, Shan WS, Colman DR |title=Conserved and divergent expression patterns of the proteolipid protein gene family in the amphibian central nervous system. |journal=J. Neurosci. Res. |volume=57 |issue= 1 |pages= 13-22 |year= 1999 |pmid= 10397631 |doi=  }}
*{{cite journal  |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA Cloning Using In Vitro Site-Specific Recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000  | pmc=310948 }}
*{{cite journal  | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi=  }}
*{{cite journal  |vauthors=Wiemann S, Weil B, Wellenreuther R |title=Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs |journal=Genome Res. |volume=11 |issue= 3 |pages= 422–35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.GR1547R  | pmc=311072 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
*{{cite journal  |vauthors=Werner H, Dimou L, Klugmann M |title=Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes |journal=Mol. Cell. Neurosci. |volume=18 |issue= 6 |pages= 593–605 |year= 2002 |pmid= 11749036 |doi= 10.1006/mcne.2001.1044 |display-authors=etal}}
*{{cite journal  | author=Werner H, Dimou L, Klugmann M, ''et al.'' |title=Multiple splice isoforms of proteolipid M6B in neurons and oligodendrocytes. |journal=Mol. Cell. Neurosci. |volume=18 |issue= 6 |pages= 593-605 |year= 2002 |pmid= 11749036 |doi= 10.1006/mcne.2001.1044 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Henneke M, Wehner LE, Hennies HC |title=Mutation analysis of the M6b gene in patients with Pelizaeus-Merzbacher-like syndrome |journal=Am. J. Med. Genet. A |volume=128 |issue= 2 |pages= 156–8 |year= 2005 |pmid= 15214007 |doi= 10.1002/ajmg.a.30068 |display-authors=etal}}
*{{cite journal  | author=Henneke M, Wehner LE, Hennies HC, ''et al.'' |title=Mutation analysis of the M6b gene in patients with Pelizaeus-Merzbacher-like syndrome. |journal=Am. J. Med. Genet. A |volume=128 |issue= 2 |pages= 156-8 |year= 2005 |pmid= 15214007 |doi= 10.1002/ajmg.a.30068 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Wiemann S, Arlt D, Huber W |title=From ORFeome to Biology: A Functional Genomics Pipeline |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 | pmc=528930 |display-authors=etal}}
*{{cite journal  | author=Wiemann S, Arlt D, Huber W, ''et al.'' |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136-44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704 }}
*{{cite journal  |vauthors=Mehrle A, Rosenfelder H, Schupp I |title=The LIFEdb database in 2006 |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 | pmc=1347501 |display-authors=etal}}
*{{cite journal  | author=Mehrle A, Rosenfelder H, Schupp I, ''et al.'' |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415-8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139 }}
}}
}}
{{refend}}
{{refend}}


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Revision as of 08:56, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Neuronal membrane glycoprotein M6-b is a protein that in humans is encoded by the GPM6B gene.[1][2]

In melanocytic cells GPM6B gene expression may be regulated by MITF.[3]


References

  1. ↑ Olinsky S, Loop BT, DeKosky A, Ripepi B, Weng W, Cummins J, Wenger SL, Yan Y, Lagenaur C, Narayanan V (Sep 1996). "Chromosomal mapping of the human M6 genes". Genomics. 33 (3): 532–6. doi:10.1006/geno.1996.0231. PMID 8661015.
  2. ↑ "Entrez Gene: GPM6B glycoprotein M6B".
  3. ↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

Further reading



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