SSX4 (gene): Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{reflist}} +{{reflist|2}}, -<references /> +{{reflist|2}}, -{{WikiDoc Cardiology Network Infobox}} +))
 
m (Bot: HTTP→HTTPS)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Underlinked|date=June 2016}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Protein SSX4''' is a [[protein]] that in humans is encoded by the ''SSX4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SSX4 synovial sarcoma, X breakpoint 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6759| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Synovial sarcoma, X breakpoint 4
| HGNCid = 11338
| Symbol = SSX4
| AltSymbols =; MGC12411
| OMIM = 300326
| ECnumber = 
| Homologene = 88596
| MGIid = 
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6759
    | Hs_Ensembl = 
    | Hs_RefseqProtein = XP_001125871
    | Hs_RefseqmRNA = XM_001125871
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Synovial sarcoma, X breakpoint 4''', also known as '''SSX4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SSX4 synovial sarcoma, X breakpoint 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6759| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SSX4 synovial sarcoma, X breakpoint 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6759| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of highly homologous [[Synovial sarcoma, X breakpoint|synovial sarcoma, X (SSX) breakpoint]] proteins. These proteins may function as transcriptional [[repressor]]s. They are also capable of eliciting spontaneously [[humoral immunity|humoral]] and [[cell-mediated immunity|cellular immune responses]] in cancer patients, and are potentially useful targets in [[cancer vaccine|cancer vaccine-based immunotherapy]]. [[SSX1]], [[SSX2]] and SSX4 genes have been involved in the t(X;18) [[chromosomal translocation]] characteristically found in all [[synovial sarcoma]]s. This translocation results in the fusion of the synovial sarcoma translocation gene on [[chromosome 18]] to one of the SSX genes on [[chromosome X]]. Chromosome Xp11 contains a [[segmental duplication]] resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more [[telomere|telomeric]] copy. Two [[transcript variants]] encoding distinct [[isoform]]s have been identified for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=dos Santos NR, de Bruijn DR, van Kessel AG |title=Molecular mechanisms underlying human synovial sarcoma development. |journal=Genes Chromosomes Cancer |volume=30 |issue= 1 |pages= 1-14 |year= 2001 |pmid= 11107170 |doi=  }}
*{{cite journal  | vauthors=dos Santos NR, de Bruijn DR, van Kessel AG |title=Molecular mechanisms underlying human synovial sarcoma development. |journal=Genes Chromosomes Cancer |volume=30 |issue= 1 |pages= 1–14 |year= 2001 |pmid= 11107170 |doi=10.1002/1098-2264(2000)9999:9999<::AID-GCC1056>3.0.CO;2-G }}
*{{cite journal | author=Gure AO, Türeci O, Sahin U, ''et al.'' |title=SSX: a multigene family with several members transcribed in normal testis and human cancer. |journal=Int. J. Cancer |volume=72 |issue= 6 |pages= 965-71 |year= 1997 |pmid= 9378559 |doi=  }}
*{{cite journal   |vauthors=Gure AO, Türeci O, Sahin U, etal |title=SSX: a multigene family with several members transcribed in normal testis and human cancer. |journal=Int. J. Cancer |volume=72 |issue= 6 |pages= 965–71 |year= 1997 |pmid= 9378559 |doi=10.1002/(SICI)1097-0215(19970917)72:6<965::AID-IJC8>3.0.CO;2-N }}
*{{cite journal | author=Skytting B, Nilsson G, Brodin B, ''et al.'' |title=A novel fusion gene, SYT-SSX4, in synovial sarcoma. |journal=J. Natl. Cancer Inst. |volume=91 |issue= 11 |pages= 974-5 |year= 1999 |pmid= 10359553 |doi=  }}
*{{cite journal   |vauthors=Skytting B, Nilsson G, Brodin B, etal |title=A novel fusion gene, SYT-SSX4, in synovial sarcoma. |journal=J. Natl. Cancer Inst. |volume=91 |issue= 11 |pages= 974–5 |year= 1999 |pmid= 10359553 |doi=10.1093/jnci/91.11.974 }}
*{{cite journal | author=Chen CH, Chen GJ, Lee HS, ''et al.'' |title=Expressions of cancer-testis antigens in human hepatocellular carcinomas. |journal=Cancer Lett. |volume=164 |issue= 2 |pages= 189-95 |year= 2001 |pmid= 11179834 |doi=  }}
*{{cite journal   |vauthors=Chen CH, Chen GJ, Lee HS, etal |title=Expressions of cancer-testis antigens in human hepatocellular carcinomas. |journal=Cancer Lett. |volume=164 |issue= 2 |pages= 189–95 |year= 2001 |pmid= 11179834 |doi=10.1016/S0304-3835(01)00379-2 }}
*{{cite journal | author=Brodin B, Haslam K, Yang K, ''et al.'' |title=Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. |journal=Gene |volume=268 |issue= 1-2 |pages= 173-82 |year= 2001 |pmid= 11368913 |doi=  }}
*{{cite journal   |vauthors=Brodin B, Haslam K, Yang K, etal |title=Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression. |journal=Gene |volume=268 |issue= 1-2 |pages= 173–82 |year= 2001 |pmid= 11368913 |doi=10.1016/S0378-1119(01)00412-7 }}
*{{cite journal | author=Panagopoulos I, Mertens F, Isaksson M, ''et al.'' |title=Clinical impact of molecular and cytogenetic findings in synovial sarcoma. |journal=Genes Chromosomes Cancer |volume=31 |issue= 4 |pages= 362-72 |year= 2001 |pmid= 11433527 |doi= 10.1002/gcc.1155 }}
*{{cite journal   |vauthors=Panagopoulos I, Mertens F, Isaksson M, etal |title=Clinical impact of molecular and cytogenetic findings in synovial sarcoma. |journal=Genes Chromosomes Cancer |volume=31 |issue= 4 |pages= 362–72 |year= 2001 |pmid= 11433527 |doi= 10.1002/gcc.1155 }}
*{{cite journal | author=de Bruijn DR, dos Santos NR, Kater-Baats E, ''et al.'' |title=The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. |journal=Genes Chromosomes Cancer |volume=34 |issue= 3 |pages= 285-98 |year= 2002 |pmid= 12007189 |doi= 10.1002/gcc.10073 }}
*{{cite journal   |vauthors=de Bruijn DR, dos Santos NR, Kater-Baats E, etal |title=The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. |journal=Genes Chromosomes Cancer |volume=34 |issue= 3 |pages= 285–98 |year= 2002 |pmid= 12007189 |doi= 10.1002/gcc.10073 }}
*{{cite journal | author=Yang K, Lui WO, Xie Y, ''et al.'' |title=Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas. |journal=Oncogene |volume=21 |issue= 26 |pages= 4181-90 |year= 2002 |pmid= 12037676 |doi= 10.1038/sj.onc.1205569 }}
*{{cite journal   |vauthors=Yang K, Lui WO, Xie Y, etal |title=Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas. |journal=Oncogene |volume=21 |issue= 26 |pages= 4181–90 |year= 2002 |pmid= 12037676 |doi= 10.1038/sj.onc.1205569 }}
*{{cite journal  | author=Güre AO, Wei IJ, Old LJ, Chen YT |title=The SSX gene family: characterization of 9 complete genes. |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 448-53 |year= 2002 |pmid= 12216073 |doi= 10.1002/ijc.10634 }}
*{{cite journal  | vauthors=Güre AO, Wei IJ, Old LJ, Chen YT |title=The SSX gene family: characterization of 9 complete genes. |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 448–53 |year= 2002 |pmid= 12216073 |doi= 10.1002/ijc.10634 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }}
*{{cite journal | author=Ayyoub M, Merlo A, Hesdorffer CS, ''et al.'' |title=CD4+ T cell responses to SSX-4 in melanoma patients. |journal=J. Immunol. |volume=174 |issue= 8 |pages= 5092-9 |year= 2005 |pmid= 15814740 |doi=  }}
*{{cite journal   |vauthors=Ayyoub M, Merlo A, Hesdorffer CS, etal |title=CD4+ T cell responses to SSX-4 in melanoma patients. |journal=J. Immunol. |volume=174 |issue= 8 |pages= 5092–9 |year= 2005 |pmid= 15814740 |doi=  10.4049/jimmunol.174.8.5092}}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


{{protein-stub}}
{{protein-stub}}
{{WikiDoc Sources}}

Revision as of 07:07, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein SSX4 is a protein that in humans is encoded by the SSX4 gene.[1]

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4, represents the more telomeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene.[1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SSX4 synovial sarcoma, X breakpoint 4".

Further reading



Retrieved from "https://www.wikidoc.org/index.php?title=SSX4_(gene)&oldid=1423004"