GEM (gene): Difference between revisions

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{{Infobox_gene}}
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'''GTP-binding protein GEM''' is a [[protein]] that in humans is encoded by the ''GEM'' [[gene]].<ref name="pmid7912851">{{cite journal |vauthors=Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K | title = Gem: an induced, immediate early protein belonging to the Ras family | journal = Science | volume = 265 | issue = 5169 | pages = 241–4 |date=Aug 1994 | pmid = 7912851 | pmc =  | doi =10.1126/science.7912851 }}</ref><ref name="pmid11956230">{{cite journal |vauthors=Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K | title = The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway | journal = J Cell Biol | volume = 157 | issue = 2 | pages = 291–302 |date=Apr 2002 | pmid = 11956230 | pmc = 2199248 | doi = 10.1083/jcb.200111026 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2669| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_GEM_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2cjw.
| PDB = {{PDB2|2cjw}}, {{PDB2|2g3y}}, {{PDB2|2ht6}}
| Name = GTP binding protein overexpressed in skeletal muscle
| HGNCid = 4234
| Symbol = GEM
| AltSymbols =; KIR; MGC26294
| OMIM = 600164
| ECnumber =
| Homologene = 38024
| MGIid = 99844
  | GeneAtlas_image1 = PBB_GE_GEM_204472_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2669
    | Hs_Ensembl = ENSG00000164949
    | Hs_RefseqProtein = NP_005252
    | Hs_RefseqmRNA = NM_005261
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 95330663
    | Hs_GenLoc_end = 95343733
    | Hs_Uniprot = P55040
    | Mm_EntrezGene = 14579
    | Mm_Ensembl = ENSMUSG00000028214
    | Mm_RefseqmRNA = NM_010276
    | Mm_RefseqProtein = NP_034406
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 11631604
    | Mm_GenLoc_end = 11641899
    | Mm_Uniprot = Q3TH76
  }}
}}
'''GTP binding protein overexpressed in skeletal muscle''', also known as '''GEM''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2669| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2669| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Cohen L, Mohr R, Chen YY, ''et al.'' |title=Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12448-52 |year= 1995 |pmid= 7809057 |doi= }}
*{{cite journal  |vauthors=Cohen L, Mohr R, Chen YY |title=Transcriptional activation of a ras-like gene (kir) by oncogenic tyrosine kinases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 26 |pages= 12448–52 |year= 1995 |pmid= 7809057 |doi=10.1073/pnas.91.26.12448  | pmc=45455  |display-authors=etal}}
*{{cite journal  | author=Maguire J, Santoro T, Jensen P, ''et al.'' |title=Gem: an induced, immediate early protein belonging to the Ras family. |journal=Science |volume=265 |issue= 5169 |pages= 241-4 |year= 1994 |pmid= 7912851 |doi= }}
*{{cite journal  |vauthors=Santoro T, Maguire J, McBride OW |title=Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein. |journal=Genomics |volume=30 |issue= 3 |pages= 558–64 |year= 1997 |pmid= 8825643 |doi= 10.1006/geno.1995.1277 |display-authors=etal}}
*{{cite journal  | author=Santoro T, Maguire J, McBride OW, ''et al.'' |title=Chromosomal organization and transcriptional regulation of human GEM and localization of the human and mouse GEM loci encoding an inducible Ras-like protein. |journal=Genomics |volume=30 |issue= 3 |pages= 558-64 |year= 1997 |pmid= 8825643 |doi= 10.1006/geno.1995.1277 }}
*{{cite journal  |vauthors=Moyers JS, Bilan PJ, Zhu J, Kahn CR |title=Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11832–9 |year= 1997 |pmid= 9115241 |doi=10.1074/jbc.272.18.11832 }}
*{{cite journal  | author=Moyers JS, Bilan PJ, Zhu J, Kahn CR |title=Rad and Rad-related GTPases interact with calmodulin and calmodulin-dependent protein kinase II. |journal=J. Biol. Chem. |volume=272 |issue= 18 |pages= 11832-9 |year= 1997 |pmid= 9115241 |doi=  }}
*{{cite journal  |vauthors=Béguin P, Nagashima K, Gonoi T |title=Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. |journal=Nature |volume=411 |issue= 6838 |pages= 701–6 |year= 2001 |pmid= 11395774 |doi= 10.1038/35079621 |display-authors=etal}}
*{{cite journal  | author=Béguin P, Nagashima K, Gonoi T, ''et al.'' |title=Regulation of Ca2+ channel expression at the cell surface by the small G-protein kir/Gem. |journal=Nature |volume=411 |issue= 6838 |pages= 701-6 |year= 2001 |pmid= 11395774 |doi= 10.1038/35079621 }}
*{{cite journal  |vauthors=Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J |title=A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. |journal=Biochem. J. |volume=367 |issue= Pt 1 |pages= 57–65 |year= 2003 |pmid= 12093360 |doi= 10.1042/BJ20020829 | pmc=1222866 }}
*{{cite journal  | author=Ward Y, Yap SF, Ravichandran V, ''et al.'' |title=The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway. |journal=J. Cell Biol. |volume=157 |issue= 2 |pages= 291-302 |year= 2002 |pmid= 11956230 |doi= 10.1083/jcb.200111026 }}
*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Aresta S, de Tand-Heim MF, Béranger F, de Gunzburg J |title=A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases. |journal=Biochem. J. |volume=367 |issue= Pt 1 |pages= 57-65 |year= 2003 |pmid= 12093360 |doi= 10.1042/BJ20020829 }}
*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kelly K |title=The RGK family: a regulatory tail of small GTP-binding proteins. |journal=Trends Cell Biol. |volume=15 |issue= 12 |pages= 640–3 |year= 2006 |pmid= 16242932 |doi= 10.1016/j.tcb.2005.10.002 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Opatowsky Y, Sasson Y, Shaked I |title=Structure-function studies of the G-domain from human gem, a novel small G-protein. |journal=FEBS Lett. |volume=580 |issue= 25 |pages= 5959–64 |year= 2006 |pmid= 17052716 |doi= 10.1016/j.febslet.2006.09.067 | pmc=1934412 |display-authors=etal}}
*{{cite journal  | author=Kelly K |title=The RGK family: a regulatory tail of small GTP-binding proteins. |journal=Trends Cell Biol. |volume=15 |issue= 12 |pages= 640-3 |year= 2006 |pmid= 16242932 |doi= 10.1016/j.tcb.2005.10.002 }}
*{{cite journal  |vauthors=Splingard A, Ménétrey J, Perderiset M |title=Biochemical and structural characterization of the gem GTPase. |journal=J. Biol. Chem. |volume=282 |issue= 3 |pages= 1905–15 |year= 2007 |pmid= 17107948 |doi= 10.1074/jbc.M604363200 |display-authors=etal}}
*{{cite journal  | author=Opatowsky Y, Sasson Y, Shaked I, ''et al.'' |title=Structure-function studies of the G-domain from human gem, a novel small G-protein. |journal=FEBS Lett. |volume=580 |issue= 25 |pages= 5959-64 |year= 2006 |pmid= 17052716 |doi= 10.1016/j.febslet.2006.09.067 }}
*{{cite journal  | author=Splingard A, Ménétrey J, Perderiset M, ''et al.'' |title=Biochemical and structural characterization of the gem GTPase. |journal=J. Biol. Chem. |volume=282 |issue= 3 |pages= 1905-15 |year= 2007 |pmid= 17107948 |doi= 10.1074/jbc.M604363200 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2669}}
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Latest revision as of 22:07, 26 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GTP-binding protein GEM is a protein that in humans is encoded by the GEM gene.[1][2][3]

The protein encoded by this gene belongs to the RAD/GEM family of GTP-binding proteins. It is associated with the inner face of the plasma membrane and could play a role as a regulatory protein in receptor-mediated signal transduction. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.[3]

References

  1. ↑ Maguire J, Santoro T, Jensen P, Siebenlist U, Yewdell J, Kelly K (Aug 1994). "Gem: an induced, immediate early protein belonging to the Ras family". Science. 265 (5169): 241–4. doi:10.1126/science.7912851. PMID 7912851.
  2. ↑ Ward Y, Yap SF, Ravichandran V, Matsumura F, Ito M, Spinelli B, Kelly K (Apr 2002). "The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway". J Cell Biol. 157 (2): 291–302. doi:10.1083/jcb.200111026. PMC 2199248. PMID 11956230.
  3. ↑ 3.0 3.1 "Entrez Gene: GEM GTP binding protein overexpressed in skeletal muscle".

Further reading



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