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{{Infobox_gene}}
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'''Selenoprotein P''' is a [[protein]] that in humans is encoded by the ''SEPP1'' [[gene]].<ref name="pmid8421687">{{cite journal | vauthors = Hill KE, Lloyd RS, Burk RF | title = Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 2 | pages = 537–41 |date=Feb 1993 | pmid = 8421687 | pmc = 45698 | doi =10.1073/pnas.90.2.537 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SEPP1 selenoprotein P, plasma, 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6414| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source =
| PDB =
| Name = Selenoprotein P, plasma, 1
| HGNCid = 10751
| Symbol = SEPP1
| AltSymbols =; SELP; SeP
| OMIM = 601484
| ECnumber = 
| Homologene = 3945
| MGIid = 894288
| Function = {{GNF_GO|id=GO:0008430 |text = selenium binding}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0001887 |text = selenium metabolic process}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0007420 |text = brain development}} {{GNF_GO|id=GO:0007626 |text = locomotory behavior}} {{GNF_GO|id=GO:0009791 |text = post-embryonic development}} {{GNF_GO|id=GO:0019953 |text = sexual reproduction}} {{GNF_GO|id=GO:0040007 |text = growth}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6414
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_005401
    | Hs_RefseqmRNA = NM_005410
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 20363
    | Mm_Ensembl = ENSMUSG00000064373
    | Mm_RefseqmRNA = NM_001042613
    | Mm_RefseqProtein = NP_001036078
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 3224674
    | Mm_GenLoc_end = 3229710
    | Mm_Uniprot = Q3TJ31
  }}
}}
'''Selenoprotein P, plasma, 1''', also known as '''SEPP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEPP1 selenoprotein P, plasma, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6414| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 10 Sec residues per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: SEPP1 selenoprotein P, plasma, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6414| accessdate = }}</ref>
| summary_text = This gene encodes a [[selenoprotein]] containing multiple [[selenocysteine]] (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular [[glycoprotein]], and is unusual in that it contains 9 Sec residues (human, rat, mouse - see Burk and Hill 2009) per polypeptide. It is a [[heparin]]-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an [[antioxidant]] in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Burk RF, Hill KE |title=Selenoprotein P. A selenium-rich extracellular glycoprotein. |journal=J. Nutr. |volume=124 |issue= 10 |pages= 1891-7 |year= 1994 |pmid= 7931697 |doi=  }}
*{{cite journal  | vauthors=Burk RF, Hill KE |title=Selenoprotein P. A selenium-rich extracellular glycoprotein |journal=J. Nutr. |volume=124 |issue= 10 |pages= 1891–7 |year= 1994 |pmid= 7931697 |doi=  }}
*{{cite journal  | author=Mostert V |title=Selenoprotein P: properties, functions, and regulation. |journal=Arch. Biochem. Biophys. |volume=376 |issue= 2 |pages= 433-8 |year= 2000 |pmid= 10775431 |doi= 10.1006/abbi.2000.1735 }}
*{{cite journal  | author=Mostert V |title=Selenoprotein P: properties, functions, and regulation |journal=Arch. Biochem. Biophys. |volume=376 |issue= 2 |pages= 433–8 |year= 2000 |pmid= 10775431 |doi= 10.1006/abbi.2000.1735 }}
*{{cite journal | author=Hill KE, Lloyd RS, Yang JG, ''et al.'' |title=The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame. |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10050-3 |year= 1991 |pmid= 2037562 |doi=  }}
*{{cite journal   |vauthors=Hill KE, Lloyd RS, Yang JG, etal |title=The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame |journal=J. Biol. Chem. |volume=266 |issue= 16 |pages= 10050–3 |year= 1991 |pmid= 2037562 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Akesson B, Bellew T, Burk RF |title=Purification of selenoprotein P from human plasma. |journal=Biochim. Biophys. Acta |volume=1204 |issue= 2 |pages= 243-9 |year= 1994 |pmid= 8142465 |doi=  }}
*{{cite journal  | vauthors=Akesson B, Bellew T, Burk RF |title=Purification of selenoprotein P from human plasma |journal=Biochim. Biophys. Acta |volume=1204 |issue= 2 |pages= 243–9 |year= 1994 |pmid= 8142465 |doi=  10.1016/0167-4838(94)90014-0}}
*{{cite journal  | author=Hill KE, Lloyd RS, Burk RF |title=Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 2 |pages= 537-41 |year= 1993 |pmid= 8421687 |doi=  }}
*{{cite journal  | vauthors=Hill KE, Dasouki M, Phillips JA, Burk RF |title=Human selenoprotein P gene maps to 5q31 |journal=Genomics |volume=36 |issue= 3 |pages= 550–1 |year= 1997 |pmid= 8884283 |doi=10.1006/geno.1996.0505 }}
*{{cite journal  | author=Hill KE, Dasouki M, Phillips JA, Burk RF |title=Human selenoprotein P gene maps to 5q31. |journal=Genomics |volume=36 |issue= 3 |pages= 550-1 |year= 1997 |pmid= 8884283 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Mostert V, Lombeck I, Abel J |title=A novel method for the purification of selenoprotein P from human plasma |journal=Arch. Biochem. Biophys. |volume=357 |issue= 2 |pages= 326–30 |year= 1998 |pmid= 9735174 |doi= 10.1006/abbi.1998.0809 }}
*{{cite journal  | author=Mostert V, Lombeck I, Abel J |title=A novel method for the purification of selenoprotein P from human plasma. |journal=Arch. Biochem. Biophys. |volume=357 |issue= 2 |pages= 326-30 |year= 1998 |pmid= 9735174 |doi= 10.1006/abbi.1998.0809 }}
*{{cite journal   |vauthors=Saito Y, Hayashi T, Tanaka A, etal |title=Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2866–71 |year= 1999 |pmid= 9915822 |doi=10.1074/jbc.274.5.2866 }}
*{{cite journal | author=Saito Y, Hayashi T, Tanaka A, ''et al.'' |title=Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p. |journal=J. Biol. Chem. |volume=274 |issue= 5 |pages= 2866-71 |year= 1999 |pmid= 9915822 |doi=  }}
*{{cite journal   |vauthors=Koyama H, Omura K, Ejima A, etal |title=Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry |journal=Anal. Biochem. |volume=267 |issue= 1 |pages= 84–91 |year= 1999 |pmid= 9918658 |doi= 10.1006/abio.1998.2949 }}
*{{cite journal | author=Koyama H, Omura K, Ejima A, ''et al.'' |title=Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry. |journal=Anal. Biochem. |volume=267 |issue= 1 |pages= 84-91 |year= 1999 |pmid= 9918658 |doi= 10.1006/abio.1998.2949 }}
*{{cite journal  | vauthors=Arteel GE, Franken S, Kappler J, Sies H |title=Binding of selenoprotein P to heparin: characterization with surface plasmon resonance |journal=Biol. Chem. |volume=381 |issue= 3 |pages= 265–8 |year= 2000 |pmid= 10782998 |doi=10.1515/BC.2000.034 }}
*{{cite journal  | author=Arteel GE, Franken S, Kappler J, Sies H |title=Binding of selenoprotein P to heparin: characterization with surface plasmon resonance. |journal=Biol. Chem. |volume=381 |issue= 3 |pages= 265-8 |year= 2000 |pmid= 10782998 |doi=  }}
*{{cite journal   |vauthors=Hondal RJ, Ma S, Caprioli RM, etal |title=Heparin-binding histidine and lysine residues of rat selenoprotein P |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 15823–31 |year= 2001 |pmid= 11278668 |doi= 10.1074/jbc.M010405200 }}
*{{cite journal | author=Hondal RJ, Ma S, Caprioli RM, ''et al.'' |title=Heparin-binding histidine and lysine residues of rat selenoprotein P. |journal=J. Biol. Chem. |volume=276 |issue= 19 |pages= 15823-31 |year= 2001 |pmid= 11278668 |doi= 10.1074/jbc.M010405200 }}
*{{cite journal   |vauthors=Nishimura K, Matsumiya K, Tsujimura A, etal |title=Association of selenoprotein P with testosterone production in cultured Leydig cells |journal=Arch. Androl. |volume=47 |issue= 1 |pages= 67–76 |year= 2001 |pmid= 11442337 |doi=10.1080/01485010152104026 }}
*{{cite journal | author=Nishimura K, Matsumiya K, Tsujimura A, ''et al.'' |title=Association of selenoprotein P with testosterone production in cultured Leydig cells. |journal=Arch. Androl. |volume=47 |issue= 1 |pages= 67-76 |year= 2001 |pmid= 11442337 |doi=  }}
*{{cite journal   |vauthors=Al-Taie OH, Seufert J, Mörk H, etal |title=A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency |journal=Eur. J. Hum. Genet. |volume=10 |issue= 9 |pages= 499–504 |year= 2003 |pmid= 12173025 |doi= 10.1038/sj.ejhg.5200811 }}
*{{cite journal | author=Al-Taie OH, Seufert J, Mörk H, ''et al.'' |title=A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency. |journal=Eur. J. Hum. Genet. |volume=10 |issue= 9 |pages= 499-504 |year= 2003 |pmid= 12173025 |doi= 10.1038/sj.ejhg.5200811 }}
*{{cite journal  | vauthors=Saito Y, Takahashi K |title=Characterization of selenoprotein P as a selenium supply protein |journal=Eur. J. Biochem. |volume=269 |issue= 22 |pages= 5746–51 |year= 2003 |pmid= 12423375 |doi=10.1046/j.1432-1033.2002.03298.x }}
*{{cite journal  | author=Saito Y, Takahashi K |title=Characterization of selenoprotein P as a selenium supply protein. |journal=Eur. J. Biochem. |volume=269 |issue= 22 |pages= 5746-51 |year= 2003 |pmid= 12423375 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
}}
{{refend}}
{{refend}}
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[[Category:Selenoproteins]]


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{{protein-stub}}
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Latest revision as of 06:07, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Selenoprotein P is a protein that in humans is encoded by the SEPP1 gene.[1][2]

This gene encodes a selenoprotein containing multiple selenocysteine (Sec) residues, which are encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is an extracellular glycoprotein, and is unusual in that it contains 9 Sec residues (human, rat, mouse - see Burk and Hill 2009) per polypeptide. It is a heparin-binding protein that appears to be associated with endothelial cells, and has been implicated to function as an antioxidant in the extracellular space. Several transcript variants, encoding either the same or different isoform, have been found for this gene.[2]

References

  1. ↑ Hill KE, Lloyd RS, Burk RF (Feb 1993). "Conserved nucleotide sequences in the open reading frame and 3' untranslated region of selenoprotein P mRNA". Proc Natl Acad Sci U S A. 90 (2): 537–41. doi:10.1073/pnas.90.2.537. PMC 45698. PMID 8421687.
  2. ↑ 2.0 2.1 "Entrez Gene: SEPP1 selenoprotein P, plasma, 1".

Further reading

  • Burk RF, Hill KE (1994). "Selenoprotein P. A selenium-rich extracellular glycoprotein". J. Nutr. 124 (10): 1891–7. PMID 7931697.
  • Mostert V (2000). "Selenoprotein P: properties, functions, and regulation". Arch. Biochem. Biophys. 376 (2): 433–8. doi:10.1006/abbi.2000.1735. PMID 10775431.
  • Hill KE, Lloyd RS, Yang JG, et al. (1991). "The cDNA for rat selenoprotein P contains 10 TGA codons in the open reading frame". J. Biol. Chem. 266 (16): 10050–3. PMID 2037562.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Akesson B, Bellew T, Burk RF (1994). "Purification of selenoprotein P from human plasma". Biochim. Biophys. Acta. 1204 (2): 243–9. doi:10.1016/0167-4838(94)90014-0. PMID 8142465.
  • Hill KE, Dasouki M, Phillips JA, Burk RF (1997). "Human selenoprotein P gene maps to 5q31". Genomics. 36 (3): 550–1. doi:10.1006/geno.1996.0505. PMID 8884283.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Mostert V, Lombeck I, Abel J (1998). "A novel method for the purification of selenoprotein P from human plasma". Arch. Biochem. Biophys. 357 (2): 326–30. doi:10.1006/abbi.1998.0809. PMID 9735174.
  • Saito Y, Hayashi T, Tanaka A, et al. (1999). "Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein p". J. Biol. Chem. 274 (5): 2866–71. doi:10.1074/jbc.274.5.2866. PMID 9915822.
  • Koyama H, Omura K, Ejima A, et al. (1999). "Separation of selenium-containing proteins in human and mouse plasma using tandem high-performance liquid chromatography columns coupled with inductively coupled plasma-mass spectrometry". Anal. Biochem. 267 (1): 84–91. doi:10.1006/abio.1998.2949. PMID 9918658.
  • Arteel GE, Franken S, Kappler J, Sies H (2000). "Binding of selenoprotein P to heparin: characterization with surface plasmon resonance". Biol. Chem. 381 (3): 265–8. doi:10.1515/BC.2000.034. PMID 10782998.
  • Hondal RJ, Ma S, Caprioli RM, et al. (2001). "Heparin-binding histidine and lysine residues of rat selenoprotein P". J. Biol. Chem. 276 (19): 15823–31. doi:10.1074/jbc.M010405200. PMID 11278668.
  • Nishimura K, Matsumiya K, Tsujimura A, et al. (2001). "Association of selenoprotein P with testosterone production in cultured Leydig cells". Arch. Androl. 47 (1): 67–76. doi:10.1080/01485010152104026. PMID 11442337.
  • Al-Taie OH, Seufert J, Mörk H, et al. (2003). "A complex DNA-repeat structure within the Selenoprotein P promoter contains a functionally relevant polymorphism and is genetically unstable under conditions of mismatch repair deficiency". Eur. J. Hum. Genet. 10 (9): 499–504. doi:10.1038/sj.ejhg.5200811. PMID 12173025.
  • Saito Y, Takahashi K (2003). "Characterization of selenoprotein P as a selenium supply protein". Eur. J. Biochem. 269 (22): 5746–51. doi:10.1046/j.1432-1033.2002.03298.x. PMID 12423375.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.


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