L3MBTL: Difference between revisions

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{{Infobox_gene}}
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'''Lethal(3)malignant brain tumor-like protein''' is a [[protein]] that in humans is encoded by the ''L3MBTL'' [[gene]].<ref name="pmid10445843">{{cite journal |vauthors=Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H | title = A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes | journal = Oncogene | volume = 18 | issue = 26 | pages = 3799–809 |date=Sep 1999 | pmid = 10445843 | pmc =  | doi = 10.1038/sj.onc.1202732 }}</ref><ref name="pmid17540172">{{cite journal | vauthors = Trojer P, Li G, ((Sims RJ III)), Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D | title = L3MBTL1, a histone-methylation-dependent chromatin lock | journal = Cell | volume = 129 | issue = 5 | pages = 915–28 |date=Jun 2007 | pmid = 17540172 | pmc =  | doi = 10.1016/j.cell.2007.03.048 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26013| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_L3MBTL_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oyx.
| PDB = {{PDB2|1oyx}}, {{PDB2|1oz2}}, {{PDB2|1oz3}}
| Name = L(3)mbt-like (Drosophila)
| HGNCid = 15905
| Symbol = L3MBTL
| AltSymbols =; DKFZp586P1522; FLJ41181; H-L(3)MBT; KIAA0681; L3MBTL1; dJ138B7.3
| OMIM = 608802
| ECnumber =
| Homologene = 41846
| MGIid = 2676663
  | GeneAtlas_image1 = PBB_GE_L3MBTL_206822_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_L3MBTL_206823_at_tn.png
| GeneAtlas_image3 = PBB_GE_L3MBTL_210306_at_tn.png
| Function = {{GNF_GO|id=GO:0003700 |text = transcription factor activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 26013
    | Hs_Ensembl = ENSG00000185513
    | Hs_RefseqProtein = NP_056293
    | Hs_RefseqmRNA = NM_015478
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 41575558
    | Hs_GenLoc_end = 41603949
    | Hs_Uniprot = Q9Y468
    | Mm_EntrezGene = 241764
    | Mm_Ensembl = ENSMUSG00000035576
    | Mm_RefseqmRNA = XM_895109
    | Mm_RefseqProtein = XP_900202
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 162638630
    | Mm_GenLoc_end = 162665966
    | Mm_Uniprot = 
  }}
}}
'''L(3)mbt-like (Drosophila)''', also known as '''L3MBTL''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26013| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26013| accessdate = }}</ref>
| summary_text = This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and [[ganglion mother cells]] in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Trojer P, Li G, Sims RJ, ''et al.'' |title=L3MBTL1, a histone-methylation-dependent chromatin lock. |journal=Cell |volume=129 |issue= 5 |pages= 915-28 |year= 2007 |pmid= 17540172 |doi= 10.1016/j.cell.2007.03.048 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=MacGrogan D, Kalakonda N, Alvarez S, etal |title=Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells |journal=Genes Chromosomes Cancer |volume=41 |issue= 3 |pages= 203–13 |year= 2004 |pmid= 15334543 |doi= 10.1002/gcc.20087 }}
*{{cite journal | author=MacGrogan D, Kalakonda N, Alvarez S, ''et al.'' |title=Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells. |journal=Genes Chromosomes Cancer |volume=41 |issue= 3 |pages= 203-13 |year= 2004 |pmid= 15334543 |doi= 10.1002/gcc.20087 }}
*{{cite journal   |vauthors=Li J, Bench AJ, Vassiliou GS, etal |title=Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 19 |pages= 7341–6 |year= 2004 |pmid= 15123827 |doi= 10.1073/pnas.0308195101 | pmc=409920 }}
*{{cite journal | author=Li J, Bench AJ, Vassiliou GS, ''et al.'' |title=Imprinting of the human L3MBTL gene, a polycomb family member located in a region of chromosome 20 deleted in human myeloid malignancies. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 19 |pages= 7341-6 |year= 2004 |pmid= 15123827 |doi= 10.1073/pnas.0308195101 }}
*{{cite journal   |vauthors=Wang WK, Tereshko V, Boccuni P, etal |title=Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets |journal=Structure |volume=11 |issue= 7 |pages= 775–89 |year= 2004 |pmid= 12842041 |doi=10.1016/S0969-2126(03)00127-8 }}
*{{cite journal | author=Wang WK, Tereshko V, Boccuni P, ''et al.'' |title=Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets. |journal=Structure |volume=11 |issue= 7 |pages= 775-89 |year= 2004 |pmid= 12842041 |doi=  }}
*{{cite journal  |vauthors=Boccuni P, MacGrogan D, Scandura JM, Nimer SD |title=The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6) |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15412–20 |year= 2003 |pmid= 12588862 |doi= 10.1074/jbc.M300592200 }}
*{{cite journal  | author=Boccuni P, MacGrogan D, Scandura JM, Nimer SD |title=The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15412-20 |year= 2003 |pmid= 12588862 |doi= 10.1074/jbc.M300592200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Deloukas P, Matthews LH, Ashurst J, etal |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
*{{cite journal   |vauthors=Fossey SC, Mychaleckyj JC, Pendleton JK, etal |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20 |journal=Genomics |volume=76 |issue= 1–3 |pages= 45–57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal | author=Fossey SC, Mychaleckyj JC, Pendleton JK, ''et al.'' |title=A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. |journal=Genomics |volume=76 |issue= 1-3 |pages= 45-57 |year= 2001 |pmid= 11549316 |doi= 10.1006/geno.2001.6584 }}
*{{cite journal   |vauthors=Dias Neto E, Correa RG, Verjovski-Almeida S, etal |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=10.1073/pnas.97.7.3491  | pmc=16267  }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi=  }}
*{{cite journal   |vauthors=Ishikawa K, Nagase T, Suyama M, etal |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro |journal=DNA Res. |volume=5 |issue= 3 |pages= 169–76 |year= 1998 |pmid= 9734811 |doi=10.1093/dnares/5.3.169 }}
*{{cite journal  | author=Koga H, Matsui S, Hirota T, ''et al.'' |title=A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. |journal=Oncogene |volume=18 |issue= 26 |pages= 3799-809 |year= 1999 |pmid= 10445843 |doi= 10.1038/sj.onc.1202732 }}
*{{cite journal | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=26013}}
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Latest revision as of 17:30, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lethal(3)malignant brain tumor-like protein is a protein that in humans is encoded by the L3MBTL gene.[1][2][3]

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant transformation of neuroblasts and ganglion mother cells in the optic centers of the brain. This gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene in a glioma cell line results in improper nuclear segregation and cytokinesis producing multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

References

  1. ↑ Koga H, Matsui S, Hirota T, Takebayashi S, Okumura K, Saya H (Sep 1999). "A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes". Oncogene. 18 (26): 3799–809. doi:10.1038/sj.onc.1202732. PMID 10445843.
  2. ↑ Trojer P, Li G, Sims RJ III, Vaquero A, Kalakonda N, Boccuni P, Lee D, Erdjument-Bromage H, Tempst P, Nimer SD, Wang YH, Reinberg D (Jun 2007). "L3MBTL1, a histone-methylation-dependent chromatin lock". Cell. 129 (5): 915–28. doi:10.1016/j.cell.2007.03.048. PMID 17540172.
  3. ↑ 3.0 3.1 "Entrez Gene: L3MBTL l(3)mbt-like (Drosophila)".

Further reading



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