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{{Infobox_gene}}
{{PBB_Controls
'''''RABAC1''''' is a [[gene]] that in humans encodes the [[protein]] Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1.<ref name="pmid10329441">{{cite journal | vauthors = Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB | title = Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) | journal = Biochemical and Biophysical Research Communications | volume = 258 | issue = 3 | pages = 657–62 | date = May 1999 | pmid = 10329441 | pmc =  | doi = 10.1006/bbrc.1999.0651 }}</ref><ref name="pmid10751420">{{cite journal | vauthors = Hutt DM, Da-Silva LF, Chang LH, Prosser DC, Ngsee JK | title = PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18511–9 | date = Jun 2000 | pmid = 10751420 | pmc =  | doi = 10.1074/jbc.M909309199 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10567| accessdate = }}</ref> It is highly conserved in eukaryotes.<ref name="pmid10329441"></ref> The protein is localized to Golgi<ref>{{cite journal | vauthors = Abdul-Ghani M, Gougeon PY, Prosser DC, Da-Silva LF, Ngsee JK | title = PRA isoforms are targeted to distinct membrane compartments | journal = The Journal of Biological Chemistry | volume = 276 | issue = 9 | pages = 6225–33 | date = Mar 2001 | pmid = 11096102 | doi = 10.1074/jbc.M009073200 }}</ref> and late endosomes,<ref>{{cite journal | vauthors = Sivars U, Aivazian D, Pfeffer SR | title = Yip3 catalyses the dissociation of endosomal Rab-GDI complexes | journal = Nature | volume = 425 | issue = 6960 | pages = 856–9 | date = Oct 2003 | pmid = 14574414 | doi = 10.1038/nature02057 }}</ref> where it plays a role in vesicular trafficking, lipid transport and cell migration.<ref>{{cite journal | vauthors = Liu HP, Wu CC, Kao HY, Huang YC, Liang Y, Chen CC, Yu JS, Chang YS | title = Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration | journal = Molecular & Cellular Proteomics | volume = 10 | issue = 3 | pages = M900641MCP200 | date = Mar 2011 | pmid = 20592422 | pmc = 3047168 | doi = 10.1074/mcp.M900641-MCP200 | url = http://www.mcponline.org/content/10/3/M900641-MCP200.long }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Rab acceptor 1 (prenylated)
| HGNCid = 9794
| Symbol = RABAC1
| AltSymbols =; PRA1; PRAF1; YIP3
| OMIM = 604925
| ECnumber = 
| Homologene = 38182
| MGIid = 1201692
| GeneAtlas_image1 = PBB_GE_RABAC1_203136_at_tn.png
| Function = {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10567
    | Hs_Ensembl = ENSG00000105404
    | Hs_RefseqProtein = NP_006414
    | Hs_RefseqmRNA = NM_006423
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 47152675
    | Hs_GenLoc_end = 47155325
    | Hs_Uniprot = Q9UI14
    | Mm_EntrezGene = 14470
    | Mm_Ensembl = ENSMUSG00000003380
    | Mm_RefseqmRNA = NM_010261
    | Mm_RefseqProtein = NP_034391
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 24678508
    | Mm_GenLoc_end = 24681421
    | Mm_Uniprot = Q9Z0S9
  }}
}}
'''Rab acceptor 1 (prenylated)''', also known as '''RABAC1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10567| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
RABAC1 has been shown to [[Protein-protein_interaction|interact]] with numerous prenylated members of the [[Rab (G-protein)|Rab GTPase]] family<ref name="pmid10329441"></ref><ref name=pmid16189514>{{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref><ref name=pmid9341137>{{cite journal | vauthors = Martincic I, Peralta ME, Ngsee JK | title = Isolation and characterization of a dual prenylated Rab and VAMP2 receptor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 43 | pages = 26991–8 | date = Oct 1997 | pmid = 9341137 | doi = 10.1074/jbc.272.43.26991 }}</ref> and [[VAMP2]].<ref name=pmid9341137/>
{{PBB_Summary
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| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Martincic I, Peralta ME, Ngsee JK | title = Isolation and characterization of a dual prenylated Rab and VAMP2 receptor | journal = The Journal of Biological Chemistry | volume = 272 | issue = 43 | pages = 26991–8 | date = Oct 1997 | pmid = 9341137 | doi = 10.1074/jbc.272.43.26991 }}
| citations =
* {{cite journal | vauthors = Fenster SD, Chung WJ, Zhai R, Cases-Langhoff C, Voss B, Garner AM, Kaempf U, Kindler S, Gundelfinger ED, Garner CC | title = Piccolo, a presynaptic zinc finger protein structurally related to bassoon | journal = Neuron | volume = 25 | issue = 1 | pages = 203–14 | date = Jan 2000 | pmid = 10707984 | doi = 10.1016/S0896-6273(00)80883-1 }}
*{{cite journal | author=Martincic I, Peralta ME, Ngsee JK |title=Isolation and characterization of a dual prenylated Rab and VAMP2 receptor. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 26991-8 |year= 1997 |pmid= 9341137 |doi=  }}
* {{cite journal | vauthors = Figueroa C, Taylor J, Vojtek AB | title = Prenylated Rab acceptor protein is a receptor for prenylated small GTPases | journal = The Journal of Biological Chemistry | volume = 276 | issue = 30 | pages = 28219–25 | date = Jul 2001 | pmid = 11335720 | doi = 10.1074/jbc.M101763200 }}
*{{cite journal  | author=Bucci C, Chiariello M, Lattero D, ''et al.'' |title=Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1). |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 657-62 |year= 1999 |pmid= 10329441 |doi= 10.1006/bbrc.1999.0651 }}
* {{cite journal | vauthors = Bucci C, De Gregorio L, Bruni CB | title = Expression analysis and chromosomal assignment of PRA1 and RILP genes | journal = Biochemical and Biophysical Research Communications | volume = 286 | issue = 4 | pages = 815–9 | date = Aug 2001 | pmid = 11520070 | doi = 10.1006/bbrc.2001.5466 }}
*{{cite journal | author=Fenster SD, Chung WJ, Zhai R, ''et al.'' |title=Piccolo, a presynaptic zinc finger protein structurally related to bassoon. |journal=Neuron |volume=25 |issue= 1 |pages= 203-14 |year= 2000 |pmid= 10707984 |doi=  }}
* {{cite journal | vauthors = Evans DT, Tillman KC, Desrosiers RC | title = Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor | journal = Journal of Virology | volume = 76 | issue = 1 | pages = 327–37 | date = Jan 2002 | pmid = 11739697 | pmc = 135700 | doi = 10.1128/JVI.76.1.327-337.2002 }}
*{{cite journal  | author=Hutt DM, Da-Silva LF, Chang LH, ''et al.'' |title=PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18511-9 |year= 2000 |pmid= 10751420 |doi= 10.1074/jbc.M909309199 }}
* {{cite journal | vauthors = Blancou P, Evans DT, Desrosiers RC | title = PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation | journal = The Journal of General Virology | volume = 86 | issue = Pt 6 | pages = 1785–90 | date = Jun 2005 | pmid = 15914857 | doi = 10.1099/vir.0.80873-0 }}
*{{cite journal  | author=Abdul-Ghani M, Gougeon PY, Prosser DC, ''et al.'' |title=PRA isoforms are targeted to distinct membrane compartments. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6225-33 |year= 2001 |pmid= 11096102 |doi= 10.1074/jbc.M009073200 }}
* {{cite journal | vauthors = Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE | title = A human protein-protein interaction network: a resource for annotating the proteome | journal = Cell | volume = 122 | issue = 6 | pages = 957–68 | date = Sep 2005 | pmid = 16169070 | doi = 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Figueroa C, Taylor J, Vojtek AB |title=Prenylated Rab acceptor protein is a receptor for prenylated small GTPases. |journal=J. Biol. Chem. |volume=276 |issue= 30 |pages= 28219-25 |year= 2001 |pmid= 11335720 |doi= 10.1074/jbc.M101763200 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Bucci C, De Gregorio L, Bruni CB |title=Expression analysis and chromosomal assignment of PRA1 and RILP genes. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 4 |pages= 815-9 |year= 2001 |pmid= 11520070 |doi= 10.1006/bbrc.2001.5466 }}
* {{cite journal | vauthors = Fo CS, Coleman CS, Wallick CJ, Vine AL, Bachmann AS | title = Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2) | journal = Gene | volume = 371 | issue = 1 | pages = 154–65 | date = Apr 2006 | pmid = 16481131 | doi = 10.1016/j.gene.2005.12.009 }}
*{{cite journal | author=Evans DT, Tillman KC, Desrosiers RC |title=Envelope glycoprotein cytoplasmic domains from diverse lentiviruses interact with the prenylated Rab acceptor. |journal=J. Virol. |volume=76 |issue= 1 |pages= 327-37 |year= 2002 |pmid= 11739697 |doi=  }}
* {{cite journal | vauthors = Liu HP, Wu CC, Chang YS | title = PRA1 promotes the intracellular trafficking and NF-kappaB signaling of EBV latent membrane protein 1 | journal = The EMBO Journal | volume = 25 | issue = 17 | pages = 4120–30 | date = Sep 2006 | pmid = 16917502 | pmc = 1560356 | doi = 10.1038/sj.emboj.7601282 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kim JT, Cho MY, Choi SC, Kim JW, Chae SK, Yoon DY, Kim JW, Lim JS | title = Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin | journal = Biochemical and Biophysical Research Communications | volume = 349 | issue = 1 | pages = 200–8 | date = Oct 2006 | pmid = 16930546 | doi = 10.1016/j.bbrc.2006.08.026 }}
*{{cite journal  | author=Sivars U, Aivazian D, Pfeffer SR |title=Yip3 catalyses the dissociation of endosomal Rab-GDI complexes. |journal=Nature |volume=425 |issue= 6960 |pages= 856-9 |year= 2003 |pmid= 14574414 |doi= 10.1038/nature02057 }}
* {{cite journal | vauthors = Dickison VM, Richmond AM, Abu Irqeba A, Martak JG, Hoge SC, Brooks MJ, Othman MI, Khanna R, Mears AJ, Chowdhury AY, Swaroop A, Ogilvie JM | title = A role for prenylated rab acceptor 1 in vertebrate photoreceptor development | journal = BMC Neuroscience | volume = 13 | pages = 152 | year = 2012 | pmid = 23241222 | pmc = 3576285 | doi = 10.1186/1471-2202-13-152 | url = http://www.biomedcentral.com/1471-2202/13/152 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Blancou P, Evans DT, Desrosiers RC |title=PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation. |journal=J. Gen. Virol. |volume=86 |issue= Pt 6 |pages= 1785-90 |year= 2005 |pmid= 15914857 |doi= 10.1099/vir.0.80873-0 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Fo CS, Coleman CS, Wallick CJ, ''et al.'' |title=Genomic organization, expression profile, and characterization of the new protein PRA1 domain family, member 2 (PRAF2). |journal=Gene |volume=371 |issue= 1 |pages= 154-65 |year= 2006 |pmid= 16481131 |doi= 10.1016/j.gene.2005.12.009 }}
*{{cite journal | author=Liu HP, Wu CC, Chang YS |title=PRA1 promotes the intracellular trafficking and NF-kappaB signaling of EBV latent membrane protein 1. |journal=EMBO J. |volume=25 |issue= 17 |pages= 4120-30 |year= 2006 |pmid= 16917502 |doi= 10.1038/sj.emboj.7601282 }}
*{{cite journal | author=Kim JT, Cho MY, Choi SC, ''et al.'' |title=Prenylated Rab acceptor 1 (PRA1) inhibits TCF/beta-catenin signaling by binding to beta-catenin. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 1 |pages= 200-8 |year= 2006 |pmid= 16930546 |doi= 10.1016/j.bbrc.2006.08.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 16:20, 8 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

RABAC1 is a gene that in humans encodes the protein Prenylated Rab acceptor 1, also called PRA1, PRAF1, or RABAC1.[1][2][3] It is highly conserved in eukaryotes.[1] The protein is localized to Golgi[4] and late endosomes,[5] where it plays a role in vesicular trafficking, lipid transport and cell migration.[6]

Interactions

RABAC1 has been shown to interact with numerous prenylated members of the Rab GTPase family[1][7][8] and VAMP2.[8]

References

  1. ↑ 1.0 1.1 1.2 Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB (May 1999). "Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1)". Biochemical and Biophysical Research Communications. 258 (3): 657–62. doi:10.1006/bbrc.1999.0651. PMID 10329441.
  2. ↑ Hutt DM, Da-Silva LF, Chang LH, Prosser DC, Ngsee JK (Jun 2000). "PRA1 inhibits the extraction of membrane-bound rab GTPase by GDI1". The Journal of Biological Chemistry. 275 (24): 18511–9. doi:10.1074/jbc.M909309199. PMID 10751420.
  3. ↑ "Entrez Gene: RABAC1 Rab acceptor 1 (prenylated)".
  4. ↑ Abdul-Ghani M, Gougeon PY, Prosser DC, Da-Silva LF, Ngsee JK (Mar 2001). "PRA isoforms are targeted to distinct membrane compartments". The Journal of Biological Chemistry. 276 (9): 6225–33. doi:10.1074/jbc.M009073200. PMID 11096102.
  5. ↑ Sivars U, Aivazian D, Pfeffer SR (Oct 2003). "Yip3 catalyses the dissociation of endosomal Rab-GDI complexes". Nature. 425 (6960): 856–9. doi:10.1038/nature02057. PMID 14574414.
  6. ↑ Liu HP, Wu CC, Kao HY, Huang YC, Liang Y, Chen CC, Yu JS, Chang YS (Mar 2011). "Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration". Molecular & Cellular Proteomics. 10 (3): M900641MCP200. doi:10.1074/mcp.M900641-MCP200. PMC 3047168. PMID 20592422.
  7. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. ↑ 8.0 8.1 Martincic I, Peralta ME, Ngsee JK (Oct 1997). "Isolation and characterization of a dual prenylated Rab and VAMP2 receptor". The Journal of Biological Chemistry. 272 (43): 26991–8. doi:10.1074/jbc.272.43.26991. PMID 9341137.

Further reading

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