Methyl-CpG-binding domain protein 2: Difference between revisions

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Orthologs
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Revision as of 21:49, 4 September 2017

Methyl-CpG-binding domain protein 2 is a protein that in humans is encoded by the MBD2 gene.^[1]^[2]

Function

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1, and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing if present in promoter regions.^[3]

Interactions

Methyl-CpG-binding domain protein 2 has been shown to interact with:

References

↑ Hendrich B, Bird A (November 1998). "Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins". Mol Cell Biol. 18 (11): 6538–47. PMC 109239. PMID 9774669.
↑ Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (September 1999). "Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes". Mamm Genome. 10 (9): 906–12. doi:10.1007/s003359901112. PMID 10441743.
↑ "Entrez Gene: MBD2 methyl-CpG binding domain protein 2".
↑ ^4.0 ^4.1 ^4.2 Brackertz M, Boeke J, Zhang R, Renkawitz R (October 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID 12183469.
↑ Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (January 2002). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol. Cell. Biol. 22 (2): 536–46. doi:10.1128/mcb.22.2.536-546.2002. PMC 139742. PMID 11756549.
↑ ^6.0 ^6.1 Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (September 1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet. 23 (1): 58–61. doi:10.1038/12659. PMID 10471499.
↑ ^7.0 ^7.1 ^7.2 Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
↑ Jiang CL, Jin SG, Pfeifer GP (December 2004). "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex". J. Biol. Chem. 279 (50): 52456–64. doi:10.1074/jbc.M409149200. PMID 15456747.
↑ Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (November 2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.
↑ Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R (November 2000). "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A". J. Biol. Chem. 275 (45): 34963–7. doi:10.1074/jbc.M005929200. PMID 10950960.

Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ (1998). "Characterization of human colon cancer antigens recognized by autologous antibodies". Int. J. Cancer. 76 (5): 652–8. doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P. PMID 9610721.
Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D (1998). "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities". Cell. 95 (2): 279–89. doi:10.1016/S0092-8674(00)81758-4. PMID 9790534.
Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL (1998). "Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex". Nature. 395 (6705): 917–21. doi:10.1038/27699. PMID 9804427.
Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M (1999). "A mammalian protein with specific demethylase activity for mCpG DNA". Nature. 397 (6720): 579–83. doi:10.1038/17533. PMID 10050851.
Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet. 23 (1): 58–61. doi:10.1038/12659. PMID 10471499.
Tatematsu KI, Yamazaki T, Ishikawa F (2000). "MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase". Genes Cells. 5 (8): 677–88. doi:10.1046/j.1365-2443.2000.00359.x. PMID 10947852.
Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R (2001). "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A". J. Biol. Chem. 275 (45): 34963–7. doi:10.1074/jbc.M005929200. PMID 10950960.
Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH (2001). "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1". J. Biol. Chem. 276 (9): 6817–24. doi:10.1074/jbc.M007372200. PMID 11102443.
Feng Q, Zhang Y (2001). "The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes". Genes Dev. 15 (7): 827–32. doi:10.1101/gad.876201. PMC 312663. PMID 11297506.
Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.
Müller-Tidow C, Kügler K, Diederichs S, Klümpen S, Möller M, Vogt U, Metzger R, Schneider PM, Berdel WE, Serve H (2001). "Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer". Br. J. Cancer. 85 (8): 1168–74. doi:10.1054/bjoc.2001.2041. PMC 2375156. PMID 11710831.
Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (2002). "Identification and Functional Characterization of the p66/p68 Components of the MeCP1 Complex". Mol. Cell. Biol. 22 (2): 536–46. doi:10.1128/MCB.22.2.536-546.2002. PMC 139742. PMID 11756549.
Bakker J, Lin X, Nelson WG (2002). "Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells". J. Biol. Chem. 277 (25): 22573–80. doi:10.1074/jbc.M203009200. PMID 11960994.
Saito M, Ishikawa F (2002). "The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2". J. Biol. Chem. 277 (38): 35434–9. doi:10.1074/jbc.M203455200. PMID 12124384.
Detich N, Theberge J, Szyf M (2002). "Promoter-specific activation and demethylation by MBD2/demethylase". J. Biol. Chem. 277 (39): 35791–4. doi:10.1074/jbc.C200408200. PMID 12177048.
Brackertz M, Boeke J, Zhang R, Renkawitz R (2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID 12183469.
Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD (2002). "Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes". J. Virol. 76 (22): 11596–604. doi:10.1128/JVI.76.22.11596-11604.2002. PMC 136775. PMID 12388720.

[pmid9774669-1] Hendrich B, Bird A (November 1998). "Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins". Mol Cell Biol. 18 (11): 6538–47. PMC 109239. PMID 9774669.

[pmid10441743-2] Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A (September 1999). "Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes". Mamm Genome. 10 (9): 906–12. doi:10.1007/s003359901112. PMID 10441743.

[entrez-3] "Entrez Gene: MBD2 methyl-CpG binding domain protein 2".

[pmid12183469-4] 4.0 ^4.1 ^4.2 Brackertz M, Boeke J, Zhang R, Renkawitz R (October 2002). "Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3". J. Biol. Chem. 277 (43): 40958–66. doi:10.1074/jbc.M207467200. PMID 12183469.

[pmid11756549-5] Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y (January 2002). "Identification and functional characterization of the p66/p68 components of the MeCP1 complex". Mol. Cell. Biol. 22 (2): 536–46. doi:10.1128/mcb.22.2.536-546.2002. PMC 139742. PMID 11756549.

[pmid10471499-6] 6.0 ^6.1 Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A (September 1999). "MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex". Nat. Genet. 23 (1): 58–61. doi:10.1038/12659. PMID 10471499.

[pmid10444591-7] 7.0 ^7.1 ^7.2 Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (August 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes Dev. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.

[pmid15456747-8] Jiang CL, Jin SG, Pfeifer GP (December 2004). "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex". J. Biol. Chem. 279 (50): 52456–64. doi:10.1074/jbc.M409149200. PMID 15456747.

[pmid11553631-9] Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y (November 2001). "Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2". J. Biol. Chem. 276 (46): 42632–8. doi:10.1074/jbc.M107048200. PMID 11553631.

[pmid10950960-10] Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R (November 2000). "The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A". J. Biol. Chem. 275 (45): 34963–7. doi:10.1074/jbc.M005929200. PMID 10950960.

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@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Methyl-CpG-binding domain protein 2''' is a [[protein]] that in humans is encoded by the ''MBD2'' [[gene]].<ref name="pmid9774669">{{cite journal | vauthors = Hendrich B, Bird A | title = Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins | journal = Mol Cell Biol | volume = 18 | issue = 11 | pages = 6538–47 | date = November 1998 | pmid = 9774669 | pmc = 109239 | doi =  }}</ref><ref name="pmid10441743">{{cite journal | vauthors = Hendrich B, Abbott C, McQueen H, Chambers D, Cross S, Bird A | title = Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes | journal = Mamm Genome | volume = 10 | issue = 9 | pages = 906–12 | date = September 1999 | pmid = 10441743 | pmc =  | doi = 10.1007/s003359901112 }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Methyl-CpG binding domain protein 2
- | HGNCid = 6917
- | Symbol = MBD2
- | AltSymbols =; DKFZp586O0821; DMTase; NY-CO-41
- | OMIM = 603547
- | ECnumber =
- | Homologene = 2918
- | MGIid = 1333813
- | GeneAtlas_image1 = PBB_GE_MBD2_202484_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_MBD2_202485_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003696 |text = satellite DNA binding}} {{GNF_GO|id=GO:0003729 |text = mRNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008327 |text = methyl-CpG binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0035197 |text = siRNA binding}}
- | Component = {{GNF_GO|id=GO:0000118 |text = histone deacetylase complex}} {{GNF_GO|id=GO:0000792 |text = heterochromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
- | Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0042711 |text = maternal behavior}} {{GNF_GO|id=GO:0043623 |text = cellular protein complex assembly}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8932
-    | Hs_Ensembl = ENSG00000134046
-    | Hs_RefseqProtein = NP_003918
-    | Hs_RefseqmRNA = NM_003927
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 18
-    | Hs_GenLoc_start = 49934573
-    | Hs_GenLoc_end = 50005156
-    | Hs_Uniprot = Q9UBB5
-    | Mm_EntrezGene = 17191
-    | Mm_Ensembl = ENSMUSG00000024513
-    | Mm_RefseqmRNA = XM_001000950
-    | Mm_RefseqProtein = XP_001000950
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 18
-    | Mm_GenLoc_start = 70693557
-    | Mm_GenLoc_end = 70751499
-    | Mm_Uniprot = Q9Z2E1
-  }}
-}}
-'''Methyl-CpG binding domain protein 2''', also known as '''MBD2''', is a human [[gene]].
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a [[methyl-CpG-binding domain]] (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1, and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing if present in promoter regions.<ref name="entrez">{{cite web | title = Entrez Gene: MBD2 methyl-CpG binding domain protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8932| accessdate = }}</ref>
-{{PBB_Summary
-| section_title =
-| summary_text = DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing.<ref name="entrez">{{cite web | title = Entrez Gene: MBD2 methyl-CpG binding domain protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8932| accessdate = }}</ref>
-}}
-==References==
+== Interactions ==
-{{reflist|2}}
-==Further reading==
+Methyl-CpG-binding domain protein 2 has been shown to [[Protein-protein interaction|interact]] with:
-{{refbegin | 2}}
+{{div col|colwidth=20em}}
-{{PBB_Further_reading
+* [[GATAD2B]],<ref name = pmid12183469/><ref name = pmid11756549>{{cite journal | vauthors = Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y | title = Identification and functional characterization of the p66/p68 components of the MeCP1 complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 2 | pages = 536–46 | date = January 2002 | pmid = 11756549 | pmc = 139742 | doi =  10.1128/mcb.22.2.536-546.2002}}</ref>
-| citations =
+* [[HDAC1]],<ref name = pmid12183469>{{cite journal | vauthors = Brackertz M, Boeke J, Zhang R, Renkawitz R | title = Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3 | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 40958–66 | date = October 2002 | pmid = 12183469 | doi = 10.1074/jbc.M207467200 }}</ref><ref name = pmid10471499>{{cite journal | vauthors = Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A | title = MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex | journal = Nat. Genet. | volume = 23 | issue = 1 | pages = 58–61 | date = September 1999 | pmid = 10471499 | doi = 10.1038/12659 }}</ref><ref name = pmid10444591>{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes Dev. | volume = 13 | issue = 15 | pages = 1924–35 | date = August 1999 | pmid = 10444591 | pmc = 316920 | doi =  10.1101/gad.13.15.1924}}</ref>
-*{{cite journal  | author=Scanlan MJ, Chen YT, Williamson B, ''et al.'' |title=Characterization of human colon cancer antigens recognized by autologous antibodies. |journal=Int. J. Cancer |volume=76 |issue= 5 |pages= 652-8 |year= 1998 |pmid= 9610721 |doi=  }}
+* [[Histone deacetylase 2]],<ref name = pmid12183469/><ref name = pmid10471499/><ref name = pmid10444591/>
-*{{cite journal  | author=Hendrich B, Bird A |title=Identification and characterization of a family of mammalian methyl-CpG binding proteins. |journal=Mol. Cell. Biol. |volume=18 |issue= 11 |pages= 6538-47 |year= 1998 |pmid= 9774669 |doi=  }}
+* [[MBD3]]<ref name = pmid10444591/><ref name = pmid15456747>{{cite journal | vauthors = Jiang CL, Jin SG, Pfeifer GP | title = MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex | journal = J. Biol. Chem. | volume = 279 | issue = 50 | pages = 52456–64 | date = December 2004 | pmid = 15456747 | doi = 10.1074/jbc.M409149200 }}</ref>
-*{{cite journal  | author=Zhang Y, LeRoy G, Seelig HP, ''et al.'' |title=The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities. |journal=Cell |volume=95 |issue= 2 |pages= 279-89 |year= 1998 |pmid= 9790534 |doi=  }}
+* [[MIZF]],<ref name = pmid11553631>{{cite journal | vauthors = Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y | title = Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2 | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 42632–8 | date = November 2001 | pmid = 11553631 | doi = 10.1074/jbc.M107048200 }}</ref>  and
-*{{cite journal  | author=Tong JK, Hassig CA, Schnitzler GR, ''et al.'' |title=Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex. |journal=Nature |volume=395 |issue= 6705 |pages= 917-21 |year= 1998 |pmid= 9804427 |doi= 10.1038/27699 }}
+* [[SIN3A]].<ref name = pmid10950960>{{cite journal | vauthors = Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R | title = The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 34963–7 | date = November 2000 | pmid = 10950960 | doi = 10.1074/jbc.M005929200 }}</ref>
-*{{cite journal  | author=Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M |title=A mammalian protein with specific demethylase activity for mCpG DNA. |journal=Nature |volume=397 |issue= 6720 |pages= 579-83 |year= 1999 |pmid= 10050851 |doi= 10.1038/17533 }}
+{{Div col end}}
-*{{cite journal  | author=Hendrich B, Abbott C, McQueen H, ''et al.'' |title=Genomic structure and chromosomal mapping of the murine and human Mbd1, Mbd2, Mbd3, and Mbd4 genes. |journal=Mamm. Genome |volume=10 |issue= 9 |pages= 906-12 |year= 1999 |pmid= 10441743 |doi=  }}
-*{{cite journal  | author=Zhang Y, Ng HH, Erdjument-Bromage H, ''et al.'' |title=Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation. |journal=Genes Dev. |volume=13 |issue= 15 |pages= 1924-35 |year= 1999 |pmid= 10444591 |doi=  }}
+== References ==
-*{{cite journal  | author=Ng HH, Zhang Y, Hendrich B, ''et al.'' |title=MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. |journal=Nat. Genet. |volume=23 |issue= 1 |pages= 58-61 |year= 1999 |pmid= 10471499 |doi= 10.1038/12659 }}
+{{reflist}}
-*{{cite journal  | author=Tatematsu KI, Yamazaki T, Ishikawa F |title=MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. |journal=Genes Cells |volume=5 |issue= 8 |pages= 677-88 |year= 2000 |pmid= 10947852 |doi=  }}
-*{{cite journal  | author=Boeke J, Ammerpohl O, Kegel S, ''et al.'' |title=The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A. |journal=J. Biol. Chem. |volume=275 |issue= 45 |pages= 34963-7 |year= 2001 |pmid= 10950960 |doi= 10.1074/jbc.M005929200 }}
+== Further reading ==
-*{{cite journal  | author=Humphrey GW, Wang Y, Russanova VR, ''et al.'' |title=Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. |journal=J. Biol. Chem. |volume=276 |issue= 9 |pages= 6817-24 |year= 2001 |pmid= 11102443 |doi= 10.1074/jbc.M007372200 }}
+{{refbegin|35em}}
-*{{cite journal  | author=Feng Q, Zhang Y |title=The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes. |journal=Genes Dev. |volume=15 |issue= 7 |pages= 827-32 |year= 2001 |pmid= 11297506 |doi= 10.1101/gad.876201 }}
+* {{cite journal | vauthors = Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, Türeci O, Sahin U, Pfreundschuh M, Old LJ | title = Characterization of human colon cancer antigens recognized by autologous antibodies | journal = Int. J. Cancer | volume = 76 | issue = 5 | pages = 652–8 | year = 1998 | pmid = 9610721 | doi = 10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P }}
-*{{cite journal  | author=Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y |title=Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2. |journal=J. Biol. Chem. |volume=276 |issue= 46 |pages= 42632-8 |year= 2001 |pmid= 11553631 |doi= 10.1074/jbc.M107048200 }}
+* {{cite journal | vauthors = Zhang Y, LeRoy G, Seelig HP, Lane WS, Reinberg D | title = The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities | journal = Cell | volume = 95 | issue = 2 | pages = 279–89 | year = 1998 | pmid = 9790534 | doi = 10.1016/S0092-8674(00)81758-4 }}
-*{{cite journal  | author=Müller-Tidow C, Kügler K, Diederichs S, ''et al.'' |title=Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer. |journal=Br. J. Cancer |volume=85 |issue= 8 |pages= 1168-74 |year= 2001 |pmid= 11710831 |doi= 10.1054/bjoc.2001.2041 }}
+* {{cite journal | vauthors = Tong JK, Hassig CA, Schnitzler GR, Kingston RE, Schreiber SL | title = Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex | journal = Nature | volume = 395 | issue = 6705 | pages = 917–21 | year = 1998 | pmid = 9804427 | doi = 10.1038/27699 }}
-*{{cite journal  | author=Feng Q, Cao R, Xia L, ''et al.'' |title=Identification and functional characterization of the p66/p68 components of the MeCP1 complex. |journal=Mol. Cell. Biol. |volume=22 |issue= 2 |pages= 536-46 |year= 2002 |pmid= 11756549 |doi=  }}
+* {{cite journal | vauthors = Bhattacharya SK, Ramchandani S, Cervoni N, Szyf M | title = A mammalian protein with specific demethylase activity for mCpG DNA | journal = Nature | volume = 397 | issue = 6720 | pages = 579–83 | year = 1999 | pmid = 10050851 | doi = 10.1038/17533 }}
-*{{cite journal  | author=Bakker J, Lin X, Nelson WG |title=Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells. |journal=J. Biol. Chem. |volume=277 |issue= 25 |pages= 22573-80 |year= 2002 |pmid= 11960994 |doi= 10.1074/jbc.M203009200 }}
+* {{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes Dev. | volume = 13 | issue = 15 | pages = 1924–35 | year = 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}
-*{{cite journal  | author=Saito M, Ishikawa F |title=The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. |journal=J. Biol. Chem. |volume=277 |issue= 38 |pages= 35434-9 |year= 2002 |pmid= 12124384 |doi= 10.1074/jbc.M203455200 }}
+* {{cite journal | vauthors = Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A | title = MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex | journal = Nat. Genet. | volume = 23 | issue = 1 | pages = 58–61 | year = 1999 | pmid = 10471499 | doi = 10.1038/12659 }}
-*{{cite journal  | author=Detich N, Theberge J, Szyf M |title=Promoter-specific activation and demethylation by MBD2/demethylase. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 35791-4 |year= 2002 |pmid= 12177048 |doi= 10.1074/jbc.C200408200 }}
+* {{cite journal | vauthors = Tatematsu KI, Yamazaki T, Ishikawa F | title = MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase | journal = Genes Cells | volume = 5 | issue = 8 | pages = 677–88 | year = 2000 | pmid = 10947852 | doi = 10.1046/j.1365-2443.2000.00359.x }}
-*{{cite journal  | author=Brackertz M, Boeke J, Zhang R, Renkawitz R |title=Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. |journal=J. Biol. Chem. |volume=277 |issue= 43 |pages= 40958-66 |year= 2002 |pmid= 12183469 |doi= 10.1074/jbc.M207467200 }}
+* {{cite journal | vauthors = Boeke J, Ammerpohl O, Kegel S, Moehren U, Renkawitz R | title = The minimal repression domain of MBD2b overlaps with the methyl-CpG-binding domain and binds directly to Sin3A | journal = J. Biol. Chem. | volume = 275 | issue = 45 | pages = 34963–7 | year = 2001 | pmid = 10950960 | doi = 10.1074/jbc.M005929200 }}
-*{{cite journal  | author=Krithivas A, Fujimuro M, Weidner M, ''et al.'' |title=Protein interactions targeting the latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus to cell chromosomes. |journal=J. Virol. |volume=76 |issue= 22 |pages= 11596-604 |year= 2002 |pmid= 12388720 |doi=  }}
+* {{cite journal | vauthors = Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH | title = Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 | journal = J. Biol. Chem. | volume = 276 | issue = 9 | pages = 6817–24 | year = 2001 | pmid = 11102443 | doi = 10.1074/jbc.M007372200 }}
-}}
+* {{cite journal | vauthors = Feng Q, Zhang Y | title = The MeCP1 complex represses transcription through preferential binding, remodeling, and deacetylating methylated nucleosomes | journal = Genes Dev. | volume = 15 | issue = 7 | pages = 827–32 | year = 2001 | pmid = 11297506 | pmc = 312663 | doi = 10.1101/gad.876201 }}
+* {{cite journal | vauthors = Sekimata M, Takahashi A, Murakami-Sekimata A, Homma Y | title = Involvement of a novel zinc finger protein, MIZF, in transcriptional repression by interacting with a methyl-CpG-binding protein, MBD2 | journal = J. Biol. Chem. | volume = 276 | issue = 46 | pages = 42632–8 | year = 2001 | pmid = 11553631 | doi = 10.1074/jbc.M107048200 }}
+* {{cite journal | vauthors = Müller-Tidow C, Kügler K, Diederichs S, Klümpen S, Möller M, Vogt U, Metzger R, Schneider PM, Berdel WE, Serve H | title = Loss of expression of HDAC-recruiting methyl-CpG-binding domain proteins in human cancer | journal = Br. J. Cancer | volume = 85 | issue = 8 | pages = 1168–74 | year = 2001 | pmid = 11710831 | pmc = 2375156 | doi = 10.1054/bjoc.2001.2041 }}
+* {{cite journal | vauthors = Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y | title = Identification and Functional Characterization of the p66/p68 Components of the MeCP1 Complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 2 | pages = 536–46 | year = 2002 | pmid = 11756549 | pmc = 139742 | doi = 10.1128/MCB.22.2.536-546.2002 }}
+* {{cite journal | vauthors = Bakker J, Lin X, Nelson WG | title = Methyl-CpG binding domain protein 2 represses transcription from hypermethylated pi-class glutathione S-transferase gene promoters in hepatocellular carcinoma cells | journal = J. Biol. Chem. | volume = 277 | issue = 25 | pages = 22573–80 | year = 2002 | pmid = 11960994 | doi = 10.1074/jbc.M203009200 }}
+* {{cite journal | vauthors = Saito M, Ishikawa F | title = The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2 | journal = J. Biol. Chem. | volume = 277 | issue = 38 | pages = 35434–9 | year = 2002 | pmid = 12124384 | doi = 10.1074/jbc.M203455200 }}
+* {{cite journal | vauthors = Detich N, Theberge J, Szyf M | title = Promoter-specific activation and demethylation by MBD2/demethylase | journal = J. Biol. Chem. | volume = 277 | issue = 39 | pages = 35791–4 | year = 2002 | pmid = 12177048 | doi = 10.1074/jbc.C200408200 }}
+* {{cite journal | vauthors = Brackertz M, Boeke J, Zhang R, Renkawitz R | title = Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3 | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 40958–66 | year = 2002 | pmid = 12183469 | doi = 10.1074/jbc.M207467200 }}
+* {{cite journal | vauthors = Krithivas A, Fujimuro M, Weidner M, Young DB, Hayward SD | title = Protein Interactions Targeting the Latency-Associated Nuclear Antigen of Kaposi's Sarcoma-Associated Herpesvirus to Cell Chromosomes | journal = J. Virol. | volume = 76 | issue = 22 | pages = 11596–604 | year = 2002 | pmid = 12388720 | pmc = 136775 | doi = 10.1128/JVI.76.22.11596-11604.2002 }}
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+[[Category:Human proteins]]
-{{WikiDoc Sources}}

Methyl-CpG-binding domain protein 2: Difference between revisions

Revision as of 21:49, 4 September 2017

Contents

Function

Interactions

References

Further reading

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