TERF2IP: Difference between revisions

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{{Infobox_gene}}
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'''Telomeric repeat-binding factor 2-interacting protein 1''' is a [[protein]] that in humans is encoded by the ''TERF2IP'' [[gene]].<ref name="pmid10850490">{{cite journal |vauthors=Li B, Oestreich S, de Lange T | title = Identification of human Rap1: implications for telomere evolution | journal = Cell | volume = 101 | issue = 5 | pages = 471–83 |date=July 2000 | pmid = 10850490 | pmc =  | doi =10.1016/S0092-8674(00)80858-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54386| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TERF2IP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1fex.
| PDB = {{PDB2|1fex}}
| Name = Telomeric repeat binding factor 2, interacting protein
| HGNCid = 19246
| Symbol = TERF2IP
| AltSymbols =; RAP1; DRIP5
| OMIM = 605061
| ECnumber = 
| Homologene = 10357
| MGIid = 1929871
| GeneAtlas_image1 = PBB_GE_TERF2IP_201174_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0043047 |text = single-stranded telomeric DNA binding}}
| Component = {{GNF_GO|id=GO:0000228 |text = nuclear chromosome}} {{GNF_GO|id=GO:0000781 |text = chromosome, telomeric region}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54386
    | Hs_Ensembl = ENSG00000166848
    | Hs_RefseqProtein = NP_061848
    | Hs_RefseqmRNA = NM_018975
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 74239144
    | Hs_GenLoc_end = 74248830
    | Hs_Uniprot = Q9NYB0
    | Mm_EntrezGene = 57321
    | Mm_Ensembl = ENSMUSG00000033430
    | Mm_RefseqmRNA = NM_020584
    | Mm_RefseqProtein = NP_065609
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 114898055
    | Mm_GenLoc_end = 114905872
    | Mm_Uniprot = Q8C2Y1
  }}
}}
'''Telomeric repeat binding factor 2, interacting protein''', also known as '''TERF2IP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54386| accessdate = }}</ref>


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==Interactions==
TERF2IP has been shown to [[Protein-protein interaction|interact]] with [[Ku80]],<ref name=pmid15100233>{{cite journal |last=O'Connor |first=Matthew S |authorlink= |author2=Safari Amin |author3=Liu Dan |author4=Qin Jun |author5=Songyang Zhou  |date=July 2004  |title=The human Rap1 protein complex and modulation of telomere length |journal=J. Biol. Chem. |volume=279 |issue=27 |pages=28585–91 |publisher= |location = United States| issn = 0021-9258| pmid = 15100233 |doi = 10.1074/jbc.M312913200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Rad50]]<ref name=pmid15100233/> and [[TERF2]].<ref name=pmid10850490 /><ref name=pmid15100233/><ref name=pmid10888888>{{cite journal |last=Zhu |first=X D |authorlink= |author2=Küster B |author3=Mann M |author4=Petrini J H |author5=de Lange T  |date=July 2000  |title=Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres |journal=Nat. Genet. |volume=25 |issue=3 |pages=347–52 |publisher= |location = UNITED STATES| issn = 1061-4036| pmid = 10888888 |doi = 10.1038/77139 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Li B, Oestreich S, de Lange T |title=Identification of human Rap1: implications for telomere evolution. |journal=Cell |volume=101 |issue= 5 |pages= 471-83 |year= 2000 |pmid= 10850490 |doi= }}
*{{cite journal   |vauthors=Zhu XD, Küster B, Mann M, etal |title=Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 347–52 |year= 2000 |pmid= 10888888 |doi= 10.1038/77139 }}
*{{cite journal | author=Zhu XD, Küster B, Mann M, ''et al.'' |title=Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres. |journal=Nat. Genet. |volume=25 |issue= 3 |pages= 347-52 |year= 2000 |pmid= 10888888 |doi= 10.1038/77139 }}
*{{cite journal   |vauthors=Hanaoka S, Nagadoi A, Yoshimura S, etal |title=NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. |journal=J. Mol. Biol. |volume=312 |issue= 1 |pages= 167–75 |year= 2001 |pmid= 11545594 |doi= 10.1006/jmbi.2001.4924 }}
*{{cite journal | author=Hanaoka S, Nagadoi A, Yoshimura S, ''et al.'' |title=NMR structure of the hRap1 Myb motif reveals a canonical three-helix bundle lacking the positive surface charge typical of Myb DNA-binding domains. |journal=J. Mol. Biol. |volume=312 |issue= 1 |pages= 167-75 |year= 2001 |pmid= 11545594 |doi= 10.1006/jmbi.2001.4924 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Loayza D, De Lange T |title=POT1 as a terminal transducer of TRF1 telomere length control. |journal=Nature |volume=423 |issue= 6943 |pages= 1013–8 |year= 2003 |pmid= 12768206 |doi= 10.1038/nature01688 }}
*{{cite journal  | author=Loayza D, De Lange T |title=POT1 as a terminal transducer of TRF1 telomere length control. |journal=Nature |volume=423 |issue= 6943 |pages= 1013-8 |year= 2003 |pmid= 12768206 |doi= 10.1038/nature01688 }}
*{{cite journal  |vauthors=Li B, de Lange T |title=Rap1 affects the length and heterogeneity of human telomeres. |journal=Mol. Biol. Cell |volume=14 |issue= 12 |pages= 5060–8 |year= 2004 |pmid= 14565979 |doi= 10.1091/mbc.E03-06-0403  | pmc=284807 }}
*{{cite journal | author=Li B, de Lange T |title=Rap1 affects the length and heterogeneity of human telomeres. |journal=Mol. Biol. Cell |volume=14 |issue= 12 |pages= 5060-8 |year= 2004 |pmid= 14565979 |doi= 10.1091/mbc.E03-06-0403 }}
*{{cite journal   |vauthors=Zhu XD, Niedernhofer L, Kuster B, etal |title=ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1489–98 |year= 2004 |pmid= 14690602 |doi=10.1016/S1097-2765(03)00478-7  }}
*{{cite journal | author=Zhu XD, Niedernhofer L, Kuster B, ''et al.'' |title=ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. |journal=Mol. Cell |volume=12 |issue= 6 |pages= 1489-98 |year= 2004 |pmid= 14690602 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=O'Connor MS, Safari A, Liu D, etal |title=The human Rap1 protein complex and modulation of telomere length. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28585–91 |year= 2004 |pmid= 15100233 |doi= 10.1074/jbc.M312913200 }}
*{{cite journal | author=O'Connor MS, Safari A, Liu D, ''et al.'' |title=The human Rap1 protein complex and modulation of telomere length. |journal=J. Biol. Chem. |volume=279 |issue= 27 |pages= 28585-91 |year= 2004 |pmid= 15100233 |doi= 10.1074/jbc.M312913200 }}
*{{cite journal   |vauthors=Liu D, Safari A, O'Connor MS, etal |title=PTOP interacts with POT1 and regulates its localization to telomeres. |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 673–80 |year= 2004 |pmid= 15181449 |doi= 10.1038/ncb1142 }}
*{{cite journal | author=Liu D, Safari A, O'Connor MS, ''et al.'' |title=PTOP interacts with POT1 and regulates its localization to telomeres. |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 673-80 |year= 2004 |pmid= 15181449 |doi= 10.1038/ncb1142 }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Ye JZ, Donigian JR, van Overbeek M, etal |title=TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47264–71 |year= 2004 |pmid= 15316005 |doi= 10.1074/jbc.M409047200 }}
*{{cite journal  | author=Ye JZ, Donigian JR, van Overbeek M, ''et al.'' |title=TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. |journal=J. Biol. Chem. |volume=279 |issue= 45 |pages= 47264-71 |year= 2004 |pmid= 15316005 |doi= 10.1074/jbc.M409047200 }}
*{{cite journal  |vauthors=Liu D, O'Connor MS, Qin J, Songyang Z |title=Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51338–42 |year= 2005 |pmid= 15383534 |doi= 10.1074/jbc.M409293200 }}
*{{cite journal | author=Liu D, O'Connor MS, Qin J, Songyang Z |title=Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. |journal=J. Biol. Chem. |volume=279 |issue= 49 |pages= 51338-42 |year= 2005 |pmid= 15383534 |doi= 10.1074/jbc.M409293200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Wan D, Gong Y, Qin W, etal |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 | pmc=524842 }}
*{{cite journal | author=Wan D, Gong Y, Qin W, ''et al.'' |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724-9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 }}
*{{cite journal   |vauthors=Antoine K, Ferbus D, Kolahgar G, etal |title=Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1. |journal=J. Cell. Biochem. |volume=95 |issue= 4 |pages= 763–8 |year= 2005 |pmid= 15838871 |doi= 10.1002/jcb.20487 }}
*{{cite journal | author=Antoine K, Ferbus D, Kolahgar G, ''et al.'' |title=Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1. |journal=J. Cell. Biochem. |volume=95 |issue= 4 |pages= 763-8 |year= 2005 |pmid= 15838871 |doi= 10.1002/jcb.20487 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Beausoleil SA, Villén J, Gerber SA, etal |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285–92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  |vauthors=Wu Y, Zacal NJ, Rainbow AJ, Zhu XD |title=XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening. |journal=DNA Repair (Amst.) |volume=6 |issue= 2 |pages= 157–66 |year= 2007 |pmid= 17055345 |doi= 10.1016/j.dnarep.2006.09.005 }}
*{{cite journal  | author=Wu Y, Zacal NJ, Rainbow AJ, Zhu XD |title=XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening. |journal=DNA Repair (Amst.) |volume=6 |issue= 2 |pages= 157-66 |year= 2007 |pmid= 17055345 |doi= 10.1016/j.dnarep.2006.09.005 }}
*{{cite journal  |vauthors=Bae NS, Baumann P |title=A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. |journal=Mol. Cell |volume=26 |issue= 3 |pages= 323–34 |year= 2007 |pmid= 17499040 |doi= 10.1016/j.molcel.2007.03.023 }}
*{{cite journal  | author=Bae NS, Baumann P |title=A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends. |journal=Mol. Cell |volume=26 |issue= 3 |pages= 323-34 |year= 2007 |pmid= 17499040 |doi= 10.1016/j.molcel.2007.03.023 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=54386}}
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Revision as of 11:46, 15 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Telomeric repeat-binding factor 2-interacting protein 1 is a protein that in humans is encoded by the TERF2IP gene.[1][2]


Interactions

TERF2IP has been shown to interact with Ku80,[3] Rad50[3] and TERF2.[1][3][4]

References

  1. ↑ 1.0 1.1 Li B, Oestreich S, de Lange T (July 2000). "Identification of human Rap1: implications for telomere evolution". Cell. 101 (5): 471–83. doi:10.1016/S0092-8674(00)80858-2. PMID 10850490.
  2. ↑ "Entrez Gene: TERF2IP telomeric repeat binding factor 2, interacting protein".
  3. ↑ 3.0 3.1 3.2 O'Connor, Matthew S; Safari Amin; Liu Dan; Qin Jun; Songyang Zhou (July 2004). "The human Rap1 protein complex and modulation of telomere length". J. Biol. Chem. United States. 279 (27): 28585–91. doi:10.1074/jbc.M312913200. ISSN 0021-9258. PMID 15100233.
  4. ↑ Zhu, X D; Küster B; Mann M; Petrini J H; de Lange T (July 2000). "Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres". Nat. Genet. UNITED STATES. 25 (3): 347–52. doi:10.1038/77139. ISSN 1061-4036. PMID 10888888.

Further reading



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