SRRM2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Serine/arginine repetitive matrix protein 2''' is a [[protein]] that in humans is encoded by the ''SRRM2'' [[gene]].<ref name="pmid10668804">{{cite journal | vauthors = Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA | title = The SRm160/300 splicing coactivator subunits | journal = RNA | volume = 6 | issue = 1 | pages = 111–20  | date = Feb 2000 | pmid = 10668804 | pmc = 1369899 | doi = 10.1017/S1355838200991982 }}</ref><ref name="pmid11004489">{{cite journal | vauthors = Sawada Y, Miura Y, Umeki K, Tamaoki T, Fujinaga K, Ohtaki S | title = Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains | journal = Biochim. Biophys. Acta | volume = 1492 | issue = 1 | pages = 191–5  | date = Sep 2000 | pmid = 11004489 | pmc =  | doi = 10.1016/s0167-4781(00)00065-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SRRM2 serine/arginine repetitive matrix 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23524| accessdate = }}</ref>
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| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Serine/arginine repetitive matrix 2
| HGNCid = 16639
| Symbol = SRRM2
| AltSymbols =; 300-KD; DKFZp686O15166; FLJ21926; FLJ22250; KIAA0324; MGC40295; SRL300; SRm300
| OMIM = 606032
| ECnumber = 
| Homologene = 69214
| MGIid = 1923206
| GeneAtlas_image1 = PBB_GE_SRRM2_208610_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SRRM2_207435_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23524
    | Hs_Ensembl = ENSG00000167978
    | Hs_RefseqProtein = NP_057417
    | Hs_RefseqmRNA = NM_016333
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 2742655
    | Hs_GenLoc_end = 2761412
    | Hs_Uniprot = Q9UQ35
    | Mm_EntrezGene = 75956
    | Mm_Ensembl = ENSMUSG00000039218
    | Mm_RefseqmRNA = XM_992312
    | Mm_RefseqProtein = XP_997406
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 23530848
    | Mm_GenLoc_end = 23552358
    | Mm_Uniprot = Q8BTI8
  }}
}}
'''Serine/arginine repetitive matrix 2''', also known as '''SRRM2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SRRM2 serine/arginine repetitive matrix 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23524| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SRRM2 has been shown to [[Protein-protein interaction|interact]] with [[Pinin]].<ref name=pmid14578391>{{cite journal | vauthors = Zimowska G, Shi J, Munguba G, Jackson MR, Alpatov R, Simmons MN, Shi Y, Sugrue SP | title = Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells | journal = Invest. Ophthalmol. Vis. Sci. | volume = 44 | issue = 11 | pages = 4715–23  | date = Nov 2003 | pmid = 14578391 | doi = 10.1167/iovs.03-0240 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res. | volume = 4 | issue = 2 | pages = 141–50 | year = 1997 | pmid = 9205841 | doi = 10.1093/dnares/4.2.141 }}
| citations =
* {{cite journal | vauthors = Blencowe BJ, Issner R, Nickerson JA, Sharp PA | title = A coactivator of pre-mRNA splicing | journal = Genes Dev. | volume = 12 | issue = 7 | pages = 996–1009 | year = 1998 | pmid = 9531537 | pmc = 316672 | doi = 10.1101/gad.12.7.996 }}
*{{cite journal | author=Nagase T, Ishikawa K, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 2 |pages= 141-50 |year= 1997 |pmid= 9205841 |doi= }}
* {{cite journal | vauthors = McGarvey T, Rosonina E, McCracken S, Li Q, Arnaout R, Mientjes E, Nickerson JA, Awrey D, Greenblatt J, Grosveld G, Blencowe BJ | title = The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes | journal = J. Cell Biol. | volume = 150 | issue = 2 | pages = 309–20 | year = 2000 | pmid = 10908574 | pmc = 2180225 | doi = 10.1083/jcb.150.2.309 }}
*{{cite journal | author=Blencowe BJ, Issner R, Nickerson JA, Sharp PA |title=A coactivator of pre-mRNA splicing. |journal=Genes Dev. |volume=12 |issue= 7 |pages= 996-1009 |year= 1998 |pmid= 9531537 |doi= }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | year = 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
*{{cite journal  | author=Blencowe BJ, Baurén G, Eldridge AG, ''et al.'' |title=The SRm160/300 splicing coactivator subunits. |journal=RNA |volume=6 |issue= 1 |pages= 111-20 |year= 2000 |pmid= 10668804 |doi=  }}
* {{cite journal | vauthors = Zimowska G, Shi J, Munguba G, Jackson MR, Alpatov R, Simmons MN, Shi Y, Sugrue SP | title = Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells | journal = Invest. Ophthalmol. Vis. Sci. | volume = 44 | issue = 11 | pages = 4715–23 | year = 2003 | pmid = 14578391 | doi = 10.1167/iovs.03-0240 }}
*{{cite journal | author=McGarvey T, Rosonina E, McCracken S, ''et al.'' |title=The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes. |journal=J. Cell Biol. |volume=150 |issue= 2 |pages= 309-20 |year= 2000 |pmid= 10908574 |doi= }}
* {{cite journal | vauthors = Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC | title = Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry | journal = Anal. Chem. | volume = 76 | issue = 10 | pages = 2763–72 | year = 2004 | pmid = 15144186 | doi = 10.1021/ac035352d }}
*{{cite journal  | author=Sawada Y, Miura Y, Umeki K, ''et al.'' |title=Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains. |journal=Biochim. Biophys. Acta |volume=1492 |issue= 1 |pages= 191-5 |year= 2000 |pmid= 11004489 |doi=  }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Curr. Biol. | volume = 14 | issue = 16 | pages = 1436–50 | year = 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Ballif BA, Villén J, Beausoleil SA, Schwartz D, Gygi SP | title = Phosphoproteomic analysis of the developing mouse brain | journal = Mol. Cell. Proteomics | volume = 3 | issue = 11 | pages = 1093–101 | year = 2004 | pmid = 15345747 | doi = 10.1074/mcp.M400085-MCP200 }}
*{{cite journal | author=Zimowska G, Shi J, Munguba G, ''et al.'' |title=Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells. |journal=Invest. Ophthalmol. Vis. Sci. |volume=44 |issue= 11 |pages= 4715-23 |year= 2003 |pmid= 14578391 |doi= }}
* {{cite journal | vauthors = Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H | title = Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer | journal = Mol. Cell. Proteomics | volume = 4 | issue = 6 | pages = 785–95 | year = 2005 | pmid = 15778465 | doi = 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
* {{cite journal | vauthors = Kim JE, Tannenbaum SR, White FM | title = Global phosphoproteome of HT-29 human colon adenocarcinoma cells | journal = J. Proteome Res. | volume = 4 | issue = 4 | pages = 1339–46 | year = 2005 | pmid = 16083285 | doi = 10.1021/pr050048h }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R | title = Phosphoproteome analysis of the human mitotic spindle | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 103 | issue = 14 | pages = 5391–6 | year = 2006 | pmid = 16565220 | pmc = 1459365 | doi = 10.1073/pnas.0507066103 }}
*{{cite journal | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nat. Biotechnol. | volume = 24 | issue = 10 | pages = 1285–92 | year = 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
*{{cite journal | author=Ballif BA, Villén J, Beausoleil SA, ''et al.'' |title=Phosphoproteomic analysis of the developing mouse brain. |journal=Mol. Cell Proteomics |volume=3 |issue= 11 |pages= 1093-101 |year= 2005 |pmid= 15345747 |doi= 10.1074/mcp.M400085-MCP200 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal  | author=Martin J, Han C, Gordon LA, ''et al.'' |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988-94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal  | author=Benzinger A, Muster N, Koch HB, ''et al.'' |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. |journal=Mol. Cell Proteomics |volume=4 |issue= 6 |pages= 785-95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 }}
*{{cite journal | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-16-stub}}

Latest revision as of 06:59, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/arginine repetitive matrix protein 2 is a protein that in humans is encoded by the SRRM2 gene.[1][2][3]

Interactions

SRRM2 has been shown to interact with Pinin.[4]

References

  1. ↑ Blencowe BJ, Baurén G, Eldridge AG, Issner R, Nickerson JA, Rosonina E, Sharp PA (Feb 2000). "The SRm160/300 splicing coactivator subunits". RNA. 6 (1): 111–20. doi:10.1017/S1355838200991982. PMC 1369899. PMID 10668804.
  2. ↑ Sawada Y, Miura Y, Umeki K, Tamaoki T, Fujinaga K, Ohtaki S (Sep 2000). "Cloning and characterization of a novel RNA-binding protein SRL300 with RS domains". Biochim. Biophys. Acta. 1492 (1): 191–5. doi:10.1016/s0167-4781(00)00065-8. PMID 11004489.
  3. ↑ "Entrez Gene: SRRM2 serine/arginine repetitive matrix 2".
  4. ↑ Zimowska G, Shi J, Munguba G, Jackson MR, Alpatov R, Simmons MN, Shi Y, Sugrue SP (Nov 2003). "Pinin/DRS/memA interacts with SRp75, SRm300 and SRrp130 in corneal epithelial cells". Invest. Ophthalmol. Vis. Sci. 44 (11): 4715–23. doi:10.1167/iovs.03-0240. PMID 14578391.

Further reading


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