CDK2AP1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Cyclin-dependent kinase 2-associated protein 1''' is an [[enzyme]] that in humans is encoded by the ''CDK2AP1'' [[gene]].<ref name="pmid9331572">{{cite journal | vauthors = Daigo Y, Suzuki K, Maruyama O, Miyoshi Y, Yasuda T, Kabuto T, Imaoka S, Fujiwara T, Takahashi E, Fujino MA, Nakamura Y | title = Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer | journal = Genes Chromosomes Cancer | volume = 20 | issue = 2 | pages = 204–7 | date = November 1997 | pmid = 9331572 | pmc =  | doi = 10.1002/(SICI)1098-2264(199710)20:2<204::AID-GCC12>3.0.CO;2-Q }}</ref><ref name="pmid9506968">{{cite journal | vauthors = Tsuji T, Duh FM, Latif F, Popescu NC, Zimonjic DB, McBride J, Matsuo K, Ohyama H, Todd R, Nagata E, Terakado N, Sasaki A, Matsumura T, Lerman MI, Wong DT | title = Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1 | journal = J Biol Chem | volume = 273 | issue = 12 | pages = 6704–9 | date = April 1998 | pmid = 9506968 | pmc = | doi = 10.1074/jbc.273.12.6704 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDK2AP1 CDK2-associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8099| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = CDK2-associated protein 1
| HGNCid = 14002
| Symbol = CDK2AP1
| AltSymbols =; DOC1; DORC1; ST19; doc-1; p12DOC-1
| OMIM = 602198
| ECnumber = 
| Homologene = 3411
| MGIid = 1202069
| GeneAtlas_image1 = PBB_GE_CDK2AP1_201938_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000084 |text = S phase of mitotic cell cycle}} {{GNF_GO|id=GO:0006261 |text = DNA-dependent DNA replication}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8099
    | Hs_Ensembl = ENSG00000111328
    | Hs_RefseqProtein = NP_004633
    | Hs_RefseqmRNA = NM_004642
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 122311495
    | Hs_GenLoc_end = 122322640
    | Hs_Uniprot = O14519
    | Mm_EntrezGene = 13445
    | Mm_Ensembl = ENSMUSG00000051303
    | Mm_RefseqmRNA = XM_991893
    | Mm_RefseqProtein = XP_996987
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 48669428
    | Mm_GenLoc_end = 48669772
    | Mm_Uniprot = O35207
  }}
}}
'''CDK2-associated protein 1''', also known as '''CDK2AP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDK2AP1 CDK2-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8099| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a specific [[CDK2]]-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for [[proteolysis]]. This protein was found to also interact with DNA polymerase alpha/[[primase]] and mediate the [[phosphorylation]] of the large p180 subunit, which suggested the regulatory role in DNA replication during [[S phase]] of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal [[keratinocyte]]s.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.<ref name="entrez">{{cite web | title = Entrez Gene: CDK2AP1 CDK2-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8099| accessdate = }}</ref>
 
}}
CDK2AP1 has been shown to [[Protein-protein interaction|interact]] with [[Cyclin-dependent kinase 2]].<ref name=pmid10938106>{{cite journal | vauthors = Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Hu MG, Hu G, Kohno Y, Lerman M, Todd R, Wong DT | title = p12DOC-1 Is a Novel Cyclin-Dependent Kinase 2-Associated Protein | language =  | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6300–7 | date = September 2000 | pmid = 10938106 | pmc = 86104 | doi = 10.1128/MCB.20.17.6300-6307.2000 }}</ref>
 
It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.<ref name = "pmid24248101">{{cite journal | vauthors = Liu L, Yang X, Ni Q, Xiao Z, Zhao Y, Han J, Sun M, Chen B | title = Interaction between p12CDK2AP1 and a novel unnamed protein product inhibits cell proliferation by regulating the cell cycle. | journal = J Mol Med Rep | volume = 9 | issue = 1 | pages = 156–62 | date = Jan 2014 | pmid = 24248101 | url = http://www.spandidos-publications.com/mmr/9/1/156 | doi=10.3892/mmr.2013.1801}}</ref>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|CDK2AP1}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Matsuo K, Shintani S, Tsuji T, Nagata E, Lerman M, McBride J, Nakahara Y, Ohyama H, Todd R, Wong DT | title = p12(DOC-1), a growth suppressor, associates with DNA polymerase alpha/primase | journal = FASEB J. | volume = 14 | issue = 10 | pages = 1318–24 | year = 2000 | pmid = 10877824 | doi = 10.1096/fj.14.10.1318 }}
| citations =
*{{cite journal | vauthors = Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Hu MG, Hu G, Kohno Y, Lerman M, Todd R, Wong DT | title = p12DOC-1 Is a Novel Cyclin-Dependent Kinase 2-Associated Protein | journal = Mol. Cell. Biol. | volume = 20 | issue = 17 | pages = 6300–7 | year = 2000 | pmid = 10938106 | pmc = 86104 | doi = 10.1128/MCB.20.17.6300-6307.2000 }}
*{{cite journal | author=Daigo Y, Suzuki K, Maruyama O, ''et al.'' |title=Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer. |journal=Genes Chromosomes Cancer |volume=20 |issue= 2 |pages= 204-7 |year= 1997 |pmid= 9331572 |doi=  }}
*{{cite journal | vauthors = Yuan Z, Sotsky Kent T, Weber TK | title = Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer | journal = Oncogene | volume = 22 | issue = 40 | pages = 6304–10 | year = 2003 | pmid = 13679870 | doi = 10.1038/sj.onc.1206609 }}
*{{cite journal  | author=Tsuji T, Duh FM, Latif F, ''et al.'' |title=Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6704-9 |year= 1998 |pmid= 9506968 |doi=  }}
*{{cite journal | vauthors = Hu MG, Hu GF, Kim Y, Tsuji T, McBride J, Hinds P, Wong DT | title = Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression | journal = Cancer Res. | volume = 64 | issue = 2 | pages = 490–9 | year = 2004 | pmid = 14744761 | doi = 10.1158/0008-5472.CAN-03-2284 }}
*{{cite journal  | author=Matsuo K, Shintani S, Tsuji T, ''et al.'' |title=p12(DOC-1), a growth suppressor, associates with DNA polymerase alpha/primase. |journal=FASEB J. |volume=14 |issue= 10 |pages= 1318-24 |year= 2000 |pmid= 10877824 |doi= }}
*{{cite journal | vauthors = Buajeeb W, Zhang X, Ohyama H, Han D, Surarit R, Kim Y, Wong DT | title = Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R) | journal = Biochem. Biophys. Res. Commun. | volume = 315 | issue = 4 | pages = 998–1003 | year = 2004 | pmid = 14985111 | doi = 10.1016/j.bbrc.2004.02.003 }}
*{{cite journal | author=Shintani S, Ohyama H, Zhang X, ''et al.'' |title=p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6300-7 |year= 2000 |pmid= 10938106 |doi= }}
*{{cite journal | vauthors = Kim Y, Ohyama H, Patel V, Figueiredo M, Wong DT | title = Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect | journal = J. Biol. Chem. | volume = 280 | issue = 24 | pages = 23273–9 | year = 2005 | pmid = 15840587 | doi = 10.1074/jbc.M412929200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | year = 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
*{{cite journal | author=Yuan Z, Sotsky Kent T, Weber TK |title=Differential expression of DOC-1 in microsatellite-unstable human colorectal cancer. |journal=Oncogene |volume=22 |issue= 40 |pages= 6304-10 |year= 2003 |pmid= 13679870 |doi= 10.1038/sj.onc.1206609 }}
*{{cite journal | vauthors = Peng H, Shintani S, Kim Y, Wong DT | title = Loss of p12CDK2-AP1 Expression in Human Oral Squamous Cell Carcinoma with Disrupted Transforming Growth Factor-β-Smad Signaling Pathway | journal = Neoplasia | volume = 8 | issue = 12 | pages = 1028–36 | year = 2007 | pmid = 17217620 | pmc = 1783720 | doi = 10.1593/neo.06580 }}
*{{cite journal | author=Hu MG, Hu GF, Kim Y, ''et al.'' |title=Role of p12(CDK2-AP1) in transforming growth factor-beta1-mediated growth suppression. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 490-9 |year= 2004 |pmid= 14744761 |doi= }}
*{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein–protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}
*{{cite journal | author=Buajeeb W, Zhang X, Ohyama H, ''et al.'' |title=Interaction of the CDK2-associated protein-1, p12(DOC-1/CDK2AP1), with its homolog, p14(DOC-1R). |journal=Biochem. Biophys. Res. Commun. |volume=315 |issue= 4 |pages= 998-1003 |year= 2004 |pmid= 14985111 |doi= 10.1016/j.bbrc.2004.02.003 }}
*{{cite journal | vauthors = Shin J, Yuan Z, Fordyce K, Sreeramoju P, Kent TS, Kim J, Wang V, Schneyer D, Weber TK | title = A del T poly T (8) mutation in the 3' untranslated region (UTR) of the CDK2-AP1 gene is functionally significant causing decreased mRNA stability resulting in decreased CDK2-AP1 expression in human microsatellite unstable (MSI) colorectal cancer (CRC) | journal = Surgery | volume = 142 | issue = 2 | pages = 222–7 | year = 2007 | pmid = 17689689 | doi = 10.1016/j.surg.2007.04.002 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Kim Y, Ohyama H, Patel V, ''et al.'' |title=Mutation of Cys105 inhibits dimerization of p12CDK2-AP1 and its growth suppressor effect. |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 23273-9 |year= 2005 |pmid= 15840587 |doi= 10.1074/jbc.M412929200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Peng H, Shintani S, Kim Y, Wong DT |title=Loss of p12CDK2-AP1 expression in human oral squamous cell carcinoma with disrupted transforming growth factor-beta-Smad signaling pathway. |journal=Neoplasia |volume=8 |issue= 12 |pages= 1028-36 |year= 2007 |pmid= 17217620 |doi= 10.1593/neo.06580 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Shin J, Yuan Z, Fordyce K, ''et al.'' |title=A del T poly T (8) mutation in the 3' untranslated region (UTR) of the CDK2-AP1 gene is functionally significant causing decreased mRNA stability resulting in decreased CDK2-AP1 expression in human microsatellite unstable (MSI) colorectal cancer (CRC). |journal=Surgery |volume=142 |issue= 2 |pages= 222-7 |year= 2007 |pmid= 17689689 |doi= 10.1016/j.surg.2007.04.002 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
{{gene-12-stub}}

Latest revision as of 02:43, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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n/a

UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in humans is encoded by the CDK2AP1 gene.[1][2][3]

Function

The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.[3]

Interactions

CDK2AP1 has been shown to interact with Cyclin-dependent kinase 2.[4]

It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.[5]

References

  1. ↑ Daigo Y, Suzuki K, Maruyama O, Miyoshi Y, Yasuda T, Kabuto T, Imaoka S, Fujiwara T, Takahashi E, Fujino MA, Nakamura Y (November 1997). "Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer". Genes Chromosomes Cancer. 20 (2): 204–7. doi:10.1002/(SICI)1098-2264(199710)20:2<204::AID-GCC12>3.0.CO;2-Q. PMID 9331572.
  2. ↑ Tsuji T, Duh FM, Latif F, Popescu NC, Zimonjic DB, McBride J, Matsuo K, Ohyama H, Todd R, Nagata E, Terakado N, Sasaki A, Matsumura T, Lerman MI, Wong DT (April 1998). "Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1". J Biol Chem. 273 (12): 6704–9. doi:10.1074/jbc.273.12.6704. PMID 9506968.
  3. ↑ 3.0 3.1 "Entrez Gene: CDK2AP1 CDK2-associated protein 1".
  4. ↑ Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Hu MG, Hu G, Kohno Y, Lerman M, Todd R, Wong DT (September 2000). "p12DOC-1 Is a Novel Cyclin-Dependent Kinase 2-Associated Protein". Mol. Cell. Biol. 20 (17): 6300–7. doi:10.1128/MCB.20.17.6300-6307.2000. PMC 86104. PMID 10938106.
  5. ↑ Liu L, Yang X, Ni Q, Xiao Z, Zhao Y, Han J, Sun M, Chen B (Jan 2014). "Interaction between p12CDK2AP1 and a novel unnamed protein product inhibits cell proliferation by regulating the cell cycle". J Mol Med Rep. 9 (1): 156–62. doi:10.3892/mmr.2013.1801. PMID 24248101.

External links

Further reading


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