PHB2: Difference between revisions

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{{Infobox_gene}}
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'''Prohibitin-2''' is a [[protein]] that in humans is encoded by the ''PHB2'' [[gene]].<ref name="pmid11302691">{{cite journal |vauthors=Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG | title = Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence | journal = Exp Cell Res | volume = 265 | issue = 2 | pages = 262–73 |date=Apr 2001 | pmid = 11302691 | pmc =  | doi = 10.1006/excr.2001.5166 }}</ref><ref name="pmid9259555">{{cite journal |vauthors=Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA | title = The prohibitin family of mitochondrial proteins regulate replicative lifespan | journal = Curr Biol | volume = 7 | issue = 8 | pages = 607–10 |date=Oct 1997 | pmid = 9259555 | pmc =  | doi =10.1016/S0960-9822(06)00261-2 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PHB2 prohibitin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11331| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Prohibitin 2
| HGNCid = 30306
| Symbol = PHB2
| AltSymbols =; p22; BAP; BCAP37; Bap37; MGC117268; PNAS-141; REA
| OMIM = 610704
| ECnumber =
  | Homologene = 5263
| MGIid = 102520
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016566 |text = specific transcriptional repressor activity}} {{GNF_GO|id=GO:0030331 |text = estrogen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 11331
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_009204
    | Hs_RefseqmRNA = NM_007273
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =   
    | Hs_Uniprot =   
    | Mm_EntrezGene = 12034
    | Mm_Ensembl = ENSMUSG00000004264
    | Mm_RefseqmRNA = NM_007531
    | Mm_RefseqProtein = NP_031557
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 124677955
    | Mm_GenLoc_end = 124682252
    | Mm_Uniprot = Q3V235
  }}
}}
'''Prohibitin 2''', also known as '''PHB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PHB2 prohibitin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11331| accessdate = }}</ref>
 
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==Interactions==
PHB2 has been shown to [[Protein-protein interaction|interact]] with [[PTMA]].<ref name=pmid12943695>{{cite journal |doi=10.1016/S0960-0760(03)00207-3 |last=Martini |first=Paolo G V |authorlink= |author2=Katzenellenbogen Benita S  |date=Jun 2003 |title=Modulation of estrogen receptor activity by selective coregulators |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue=2–5 |pages=117–22 |publisher= |location = England| issn = 0960-0760| pmid = 12943695 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
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| citations =  
| citations =  
*{{cite journal  | author=Martini PG, Katzenellenbogen BS |title=Modulation of estrogen receptor activity by selective coregulators. |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2-5 |pages= 117-22 |year= 2003 |pmid= 12943695 |doi=  }}
*{{cite journal  |vauthors=Martini PG, Katzenellenbogen BS |title=Modulation of estrogen receptor activity by selective coregulators |journal=J. Steroid Biochem. Mol. Biol. |volume=85 |issue= 2–5 |pages= 117–22 |year= 2003 |pmid= 12943695 |doi=10.1016/S0960-0760(03)00207-3 }}
*{{cite journal | author=Ansari-Lari MA, Muzny DM, Lu J, ''et al.'' |title=A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. |journal=Genome Res. |volume=6 |issue= 4 |pages= 314-26 |year= 1996 |pmid= 8723724 |doi=  }}
*{{cite journal   |vauthors=Ansari-Lari MA, Muzny DM, Lu J, etal |title=A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13 |journal=Genome Res. |volume=6 |issue= 4 |pages= 314–26 |year= 1996 |pmid= 8723724 |doi=10.1101/gr.6.4.314 }}
*{{cite journal | author=Ansari-Lari MA, Shen Y, Muzny DM, ''et al.'' |title=Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. |journal=Genome Res. |volume=7 |issue= 3 |pages= 268-80 |year= 1997 |pmid= 9074930 |doi= }}
*{{cite journal   |vauthors=Ansari-Lari MA, Shen Y, Muzny DM, etal |title=Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination |journal=Genome Res. |volume=7 |issue= 3 |pages= 268–80 |year= 1997 |pmid= 9074930 |doi=10.1101/gr.7.3.268 }}
*{{cite journal  | author=Coates PJ, Jamieson DJ, Smart K, ''et al.'' |title=The prohibitin family of mitochondrial proteins regulate replicative lifespan. |journal=Curr. Biol. |volume=7 |issue= 8 |pages= 607-10 |year= 1997 |pmid= 9259555 |doi= }}
*{{cite journal   |vauthors=Montano MM, Ekena K, Delage-Mourroux R, etal |title=An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6947–52 |year= 1999 |pmid= 10359819 |doi=10.1073/pnas.96.12.6947  | pmc=22022 }}
*{{cite journal | author=Montano MM, Ekena K, Delage-Mourroux R, ''et al.'' |title=An estrogen receptor-selective coregulator that potentiates the effectiveness of antiestrogens and represses the activity of estrogens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6947-52 |year= 1999 |pmid= 10359819 |doi=  }}
*{{cite journal   |vauthors=Hu RM, Han ZG, Song HD, etal |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543–8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 | pmc=16901 }}
*{{cite journal | author=Hu RM, Han ZG, Song HD, ''et al.'' |title=Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 17 |pages= 9543-8 |year= 2000 |pmid= 10931946 |doi= 10.1073/pnas.160270997 }}
*{{cite journal  |vauthors=Martini PG, Delage-Mourroux R, Kraichely DM, Katzenellenbogen BS |title=Prothymosin Alpha Selectively Enhances Estrogen Receptor Transcriptional Activity by Interacting with a Repressor of Estrogen Receptor Activity |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6224–32 |year= 2000 |pmid= 10938099 |doi=10.1128/MCB.20.17.6224-6232.2000  | pmc=86097  }}
*{{cite journal  | author=Martini PG, Delage-Mourroux R, Kraichely DM, Katzenellenbogen BS |title=Prothymosin alpha selectively enhances estrogen receptor transcriptional activity by interacting with a repressor of estrogen receptor activity. |journal=Mol. Cell. Biol. |volume=20 |issue= 17 |pages= 6224-32 |year= 2000 |pmid= 10938099 |doi= }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Coates PJ, Nenutil R, McGregor A, ''et al.'' |title=Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence. |journal=Exp. Cell Res. |volume=265 |issue= 2 |pages= 262-73 |year= 2001 |pmid= 11302691 |doi= 10.1006/excr.2001.5166 }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kurtev V, Margueron R, Kroboth K, etal |title=Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24834–43 |year= 2004 |pmid= 15140878 |doi= 10.1074/jbc.M312300200 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal  |vauthors=Lehner B, Sanderson CM |title=A Protein Interaction Framework for Human mRNA Degradation |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 | pmc=442147 }}
*{{cite journal | author=Kurtev V, Margueron R, Kroboth K, ''et al.'' |title=Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. |journal=J. Biol. Chem. |volume=279 |issue= 23 |pages= 24834-43 |year= 2004 |pmid= 15140878 |doi= 10.1074/jbc.M312300200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal   |vauthors=Rush J, Moritz A, Lee KA, etal |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal   |vauthors=Scherer SE, Muzny DM, Buhay CJ, etal |title=The finished DNA sequence of human chromosome 12 |journal=Nature |volume=440 |issue= 7082 |pages= 346–51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |vauthors=Kasashima K, Ohta E, Kagawa Y, Endo H |title=Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2 |journal=J. Biol. Chem. |volume=281 |issue= 47 |pages= 36401–10 |year= 2007 |pmid= 17008324 |doi= 10.1074/jbc.M605260200 }}
*{{cite journal | author=Scherer SE, Muzny DM, Buhay CJ, ''et al.'' |title=The finished DNA sequence of human chromosome 12. |journal=Nature |volume=440 |issue= 7082 |pages= 346-51 |year= 2006 |pmid= 16541075 |doi= 10.1038/nature04569 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Kasashima K, Ohta E, Kagawa Y, Endo H |title=Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2. |journal=J. Biol. Chem. |volume=281 |issue= 47 |pages= 36401-10 |year= 2007 |pmid= 17008324 |doi= 10.1074/jbc.M605260200 }}
*{{cite journal   |vauthors=Takata H, Matsunaga S, Morimoto A, etal |title=PHB2 protects sister-chromatid cohesion in mitosis |journal=Curr. Biol. |volume=17 |issue= 15 |pages= 1356–61 |year= 2007 |pmid= 17656096 |doi= 10.1016/j.cub.2007.07.009 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
*{{cite journal | author=Takata H, Matsunaga S, Morimoto A, ''et al.'' |title=PHB2 protects sister-chromatid cohesion in mitosis. |journal=Curr. Biol. |volume=17 |issue= 15 |pages= 1356-61 |year= 2007 |pmid= 17656096 |doi= 10.1016/j.cub.2007.07.009 }}
}}
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Revision as of 18:02, 7 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Prohibitin-2 is a protein that in humans is encoded by the PHB2 gene.[1][2][3]


Interactions

PHB2 has been shown to interact with PTMA.[4]

References

  1. ↑ Coates PJ, Nenutil R, McGregor A, Picksley SM, Crouch DH, Hall PA, Wright EG (Apr 2001). "Mammalian prohibitin proteins respond to mitochondrial stress and decrease during cellular senescence". Exp Cell Res. 265 (2): 262–73. doi:10.1006/excr.2001.5166. PMID 11302691.
  2. ↑ Coates PJ, Jamieson DJ, Smart K, Prescott AR, Hall PA (Oct 1997). "The prohibitin family of mitochondrial proteins regulate replicative lifespan". Curr Biol. 7 (8): 607–10. doi:10.1016/S0960-9822(06)00261-2. PMID 9259555.
  3. ↑ "Entrez Gene: PHB2 prohibitin 2".
  4. ↑ Martini, Paolo G V; Katzenellenbogen Benita S (Jun 2003). "Modulation of estrogen receptor activity by selective coregulators". J. Steroid Biochem. Mol. Biol. England. 85 (2–5): 117–22. doi:10.1016/S0960-0760(03)00207-3. ISSN 0960-0760. PMID 12943695.

Further reading



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