RNF41: Difference between revisions

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Identifiers
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External IDs	GeneCards: [1]
Orthologs
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Latest revision as of 09:21, 10 September 2017

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.^[1]

Function

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.^[1]

Interactions

RNF41 has been shown to interact with USP8.^[2]

References

↑ ^1.0 ^1.1 "Entrez Gene: RNF41 ring finger protein 41".
↑ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.

Cao Z, Wu X, Yen L, Sweeney C, Carraway KL (2007). "Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1". Mol. Cell. Biol. 27 (6): 2180–8. doi:10.1128/MCB.01245-06. PMC 1820496. PMID 17210635.
Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S (2006). "Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8)". J. Biol. Chem. 281 (49): 38061–70. doi:10.1074/jbc.M606704200. PMID 17035239.
Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
Qiu XB, Markant SL, Yuan J, Goldberg AL (2004). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992. PMID 14765125.
Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G (2004). "Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network". J. Biol. Chem. 279 (13): 12804–11. doi:10.1074/jbc.M312171200. PMID 14676191.
Qiu XB, Goldberg AL (2002). "Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3". Proc. Natl. Acad. Sci. U.S.A. 99 (23): 14843–8. doi:10.1073/pnas.232580999. PMC 137506. PMID 12411582.
Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL (2002). "An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2866–71. doi:10.1073/pnas.052709799. PMC 122439. PMID 11867753.
Abdullah JM, Li X, Nachtman RG, Jurecic R (2001). "FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors". Blood Cells Mol. Dis. 27 (1): 320–33. doi:10.1006/bcmd.2001.0390. PMID 11358394.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.

External links

RNF41+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
RNF41 human gene location in the UCSC Genome Browser.
RNF41 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[entrez-1] 1.0 ^1.1 "Entrez Gene: RNF41 ring finger protein 41".

[pmid15314180-2] Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''E3 ubiquitin-protein ligase NRDP1''' is an [[enzyme]] that in humans is encoded by the ''RNF41'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF41 ring finger protein 41| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193| accessdate = }}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image = PBB_Protein_RNF41_image.jpg
- | image_source = [[Protein_Data_Bank|PDB]] rendering based on 2fzp.
- | PDB = {{PDB2|2fzp}}, {{PDB2|2gwf}}, {{PDB2|2ogb}}
- | Name = Ring finger protein 41
- | HGNCid = 18401
- | Symbol = RNF41
- | AltSymbols =; MGC45228; NRDP1; SBBI03
- | OMIM =
- | ECnumber =
- | Homologene = 4226
- | MGIid = 1914838
- | GeneAtlas_image1 = PBB_GE_RNF41_201961_s_at_tn.png
- | GeneAtlas_image2 = PBB_GE_RNF41_201962_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
- | Component =
- | Process = {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10193
-    | Hs_Ensembl = ENSG00000181852
-    | Hs_RefseqProtein = NP_005776
-    | Hs_RefseqmRNA = NM_005785
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 54884555
-    | Hs_GenLoc_end = 54902002
-    | Hs_Uniprot = Q9H4P4
-    | Mm_EntrezGene = 67588
-    | Mm_Ensembl = ENSMUSG00000025373
-    | Mm_RefseqmRNA = NM_026259
-    | Mm_RefseqProtein = NP_080535
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 10
-    | Mm_GenLoc_start = 127814606
-    | Mm_GenLoc_end = 127844390
-    | Mm_Uniprot = Q99MS2
-  }}
-}}
-'''Ring finger protein 41''', also known as '''RNF41''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNF41 ring finger protein 41| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref name="entrez" />
-{{PBB_Summary
-| section_title =
-| summary_text = The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. The specific function of this protein has not yet been determined. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: RNF41 ring finger protein 41| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10193| accessdate = }}</ref>
-}}
-==See also==
+== Interactions ==
+RNF41 has been shown to [[Protein-protein interaction|interact]] with [[USP8]].<ref name=pmid15314180>{{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Mol. Cell. Biol. | volume = 24 | issue = 17 | pages = 7748–57  | date = September 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }}</ref>
+== See also ==
 * [[RING finger domain]]
-==References==
+== References ==
-{{reflist|2}}
+{{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Cao Z, Wu X, Yen L, Sweeney C, Carraway KL | title = Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1 | journal = Mol. Cell. Biol. | volume = 27 | issue = 6 | pages = 2180–8 | year = 2007 | pmid = 17210635 | pmc = 1820496 | doi = 10.1128/MCB.01245-06 }}
-| citations =
+* {{cite journal | vauthors = Avvakumov GV, Walker JR, Xue S, Finerty PJ, Mackenzie F, Newman EM, Dhe-Paganon S | title = Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8) | journal = J. Biol. Chem. | volume = 281 | issue = 49 | pages = 38061–70 | year = 2006 | pmid = 17035239 | doi = 10.1074/jbc.M606704200 }}
-*{{cite journal  | author=Cao Z, Wu X, Yen L, ''et al.'' |title=Neuregulin-induced ErbB3 downregulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. |journal=Mol. Cell. Biol. |volume=27 |issue= 6 |pages= 2180-8 |year= 2007 |pmid= 17210635 |doi= 10.1128/MCB.01245-06 }}
+* {{cite journal | vauthors = Wu X, Yen L, Irwin L, Sweeney C, Carraway KL | title = Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8 | journal = Mol. Cell. Biol. | volume = 24 | issue = 17 | pages = 7748–57 | year = 2004 | pmid = 15314180 | pmc = 506982 | doi = 10.1128/MCB.24.17.7748-7757.2004 }}
-*{{cite journal  | author=Avvakumov GV, Walker JR, Xue S, ''et al.'' |title=Amino-terminal dimerization, NRDP1-rhodanese interaction, and inhibited catalytic domain conformation of the ubiquitin-specific protease 8 (USP8). |journal=J. Biol. Chem. |volume=281 |issue= 49 |pages= 38061-70 |year= 2007 |pmid= 17035239 |doi= 10.1074/jbc.M606704200 }}
+* {{cite journal | vauthors = Qiu XB, Markant SL, Yuan J, Goldberg AL | title = Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis | journal = EMBO J. | volume = 23 | issue = 4 | pages = 800–10 | year = 2004 | pmid = 14765125 | pmc = 380992 | doi = 10.1038/sj.emboj.7600075 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+* {{cite journal | vauthors = Brajenovic M, Joberty G, Küster B, Bouwmeester T, Drewes G | title = Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network | journal = J. Biol. Chem. | volume = 279 | issue = 13 | pages = 12804–11 | year = 2004 | pmid = 14676191 | doi = 10.1074/jbc.M312171200 }}
-*{{cite journal  | author=Wu X, Yen L, Irwin L, ''et al.'' |title=Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7748-57 |year= 2004 |pmid= 15314180 |doi= 10.1128/MCB.24.17.7748-7757.2004 }}
+* {{cite journal | vauthors = Qiu XB, Goldberg AL | title = Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 23 | pages = 14843–8 | year = 2002 | pmid = 12411582 | pmc = 137506 | doi = 10.1073/pnas.232580999 }}
-*{{cite journal  | author=Qiu XB, Markant SL, Yuan J, Goldberg AL |title=Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis. |journal=EMBO J. |volume=23 |issue= 4 |pages= 800-10 |year= 2005 |pmid= 14765125 |doi= 10.1038/sj.emboj.7600075 }}
+* {{cite journal | vauthors = Diamonti AJ, Guy PM, Ivanof C, Wong K, Sweeney C, Carraway KL | title = An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2866–71 | year = 2002 | pmid = 11867753 | pmc = 122439 | doi = 10.1073/pnas.052709799 }}
-*{{cite journal  | author=Brajenovic M, Joberty G, Küster B, ''et al.'' |title=Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12804-11 |year= 2004 |pmid= 14676191 |doi= 10.1074/jbc.M312171200 }}
+* {{cite journal | vauthors = Abdullah JM, Li X, Nachtman RG, Jurecic R | title = FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors | journal = Blood Cells Mol. Dis. | volume = 27 | issue = 1 | pages = 320–33 | year = 2001 | pmid = 11358394 | doi = 10.1006/bcmd.2001.0390 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
-*{{cite journal  | author=Qiu XB, Goldberg AL |title=Nrdp1/FLRF is a ubiquitin ligase promoting ubiquitination and degradation of the epidermal growth factor receptor family member, ErbB3. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 23 |pages= 14843-8 |year= 2003 |pmid= 12411582 |doi= 10.1073/pnas.232580999 }}
+* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
-*{{cite journal  | author=Diamonti AJ, Guy PM, Ivanof C, ''et al.'' |title=An RBCC protein implicated in maintenance of steady-state neuregulin receptor levels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 5 |pages= 2866-71 |year= 2002 |pmid= 11867753 |doi= 10.1073/pnas.052709799 }}
-*{{cite journal  | author=Abdullah JM, Li X, Nachtman RG, Jurecic R |title=FLRF, a novel evolutionarily conserved RING finger gene, is differentially expressed in mouse fetal and adult hematopoietic stem cells and progenitors. |journal=Blood Cells Mol. Dis. |volume=27 |issue= 1 |pages= 320-33 |year= 2001 |pmid= 11358394 |doi= 10.1006/bcmd.2001.0390 }}
-*{{cite journal  | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi=  }}
-*{{cite journal  | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
-}}
 {{refend}}
 == External links ==
 * {{MeshName|RNF41+protein,+human}}
+* {{UCSC genome browser|RNF41}}
+* {{UCSC gene details|RNF41}}
+{{PDB Gallery|geneid=10193}}
+[[Category:RING finger proteins]]
-{{protein-stub}}
+{{gene-12-stub}}
-{{WikiDoc Sources}}

RNF41: Difference between revisions

Latest revision as of 09:21, 10 September 2017

Contents

Function

Interactions

See also

References

Further reading

External links

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